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Åsa Birna Birgisdottir et al.
Autophagy, 15(8), 1333-1355 (2019-02-16)
Autophagosome formation depends on a carefully orchestrated interplay between membrane-associated protein complexes. Initiation of macroautophagy/autophagy is mediated by the ULK1 (unc-51 like autophagy activating kinase 1) protein kinase complex and the autophagy-specific class III phosphatidylinositol 3-kinase complex I (PtdIns3K-C1). The...
Fabian Moine et al.
BMC biology, 16(1), 12-12 (2018-01-20)
The mouse Grueneberg ganglion (GG) is an olfactory subsystem specialized in the detection of volatile heterocyclic compounds signalling danger. The signalling pathways transducing the danger signals are only beginning to be characterized. Screening chemical libraries for compounds structurally resembling the...
Jakob Mejlvang et al.
The Journal of cell biology, 217(10), 3640-3655 (2018-07-19)
It is not clear to what extent starvation-induced autophagy affects the proteome on a global scale and whether it is selective. In this study, we report based on quantitative proteomics that cells during the first 4 h of acute starvation...
Marta Targosz-Korecka et al.
Biochimica et biophysica acta. General subjects, 1864(4), 129533-129533 (2020-01-19)
Epidemiologic studies suggest that diabetes is associated with an increased risk of cancer. Concurrently, clinical trials have shown that metformin, which is a first-line antidiabetic drug, displays anticancer activity. The underlying mechanisms for these effects are, however, still not well...
Joschka Hellmeier et al.
Proceedings of the National Academy of Sciences of the United States of America, 118(4) (2021-01-21)
T cells detect with their T cell antigen receptors (TCRs) the presence of rare agonist peptide/MHC complexes (pMHCs) on the surface of antigen-presenting cells (APCs). How extracellular ligand binding triggers intracellular signaling is poorly understood, yet spatial antigen arrangement on...
Louisa V Ashby et al.
Free radical biology & medicine, 159, 119-124 (2020-08-03)
The bactericidal activity of the physiological oxidant hypochlorous acid (HOCl) is commonly studied in a variety of laboratory media. Reactive with numerous targets, HOCl will rapidly lose its toxicity via reduction or be converted to chloramines and other less toxic...
Pauline Latzer et al.
Frontiers in cellular neuroscience, 13, 113-113 (2019-04-12)
A hallmark of glioblastoma multiforme (GBM) is neoangiogenesis, mediated by the overexpression of vascular endothelial growth factor (VEGF). Anti-VEGF antibodies, like bevacizumab, prolong progression-free survival in GBM, however, this treatment has been reported to be associated with a decline in...
Stephanie J Wong et al.
Hearing research, 374, 24-34 (2019-02-01)
Auditory-nerve fibers are lost steadily with age and as a possible consequence of noise-induced glutamate excitotoxicity. Auditory-nerve loss in the absence of other cochlear pathologies is thought to be undetectable with a pure-tone audiogram while degrading real-world speech perception (hidden...
Nadja Osterberg et al.
Cell and tissue research, 336(1), 11-20 (2009-02-19)
Serotonergic (5-HT) neurons of the reticular formation play a key role in the modulation of behavior, and their dysfunction is associated with severe neurological and psychiatric disorders, such as depression and schizophrenia. However, the molecular mechanisms underlying the differentiation of...
Akiko Hirao et al.
PloS one, 4(9), e6909-e6909 (2009-09-10)
The peripheral circadian clock in mice is entrained not only by light-dark cycles but also by daily restricted feeding schedules. Behavioral and cell culture experiments suggest an increase in glucose level as a factor in such feeding-induced entrainment. For application...
Raju V S Rajala et al.
Journal of neurochemistry, 110(5), 1648-1660 (2009-07-07)
The insulin receptor (IR) and IR signaling proteins are widely distributed throughout the CNS. IR signaling provides a trophic signal for transformed retinal neurons in culture and we recently reported that deletion of IR in rod photoreceptors by Cre/lox system...
Kenneth S Henry et al.
Journal of the Association for Research in Otolaryngology : JARO (2018-05-11)
Permanent loss of auditory nerve (AN) fibers occurs with increasing age and sound overexposure, sometimes without hair cell damage or associated audiometric threshold elevation. Rodent studies suggest effects of AN damage on central processing and behavior, but these species have...
So Woon Kim et al.
Autophagy, 15(2), 327-340 (2018-09-15)
MCOLN3/TRPML3 is a Ca2+-permeable cation channel that is expressed in multiple subcellular compartments with dynamic localization. Our previous studies suggest that upon macroautophagy/autophagy induction MCOLN3/TRPML3 is recruited and provides Ca2+ for the fusion process in autophagosome biogenesis. However, how intracellular...
Perla Tedesco et al.
Frontiers in veterinary science, 7, 83-83 (2020-03-11)
The fish parasites Saprolegnia spp. (Oomycota) and Amyloodinium ocellatum (Dinophyceae) cause important losses in freshwater and marine aquaculture industry, respectively. The possible adverse effects of compounds used to control these parasites in aquaculture resulted in increased interest on the search...
Bogdan Istrate et al.
Materials (Basel, Switzerland), 13(14) (2020-07-16)
In recent years, biodegradable Mg-based materials have been increasingly studied to be used in the medical industry and beyond. A way to improve biodegradability rate in sync with the healing process of the natural human bone is to alloy Mg...
Justin Ng et al.
Journal of molecular biology, 430(18 Pt B), 3439-3453 (2018-05-11)
The amyloid-beta (Aβ) peptide, commonly found in elevated levels in the brains of patients with Alzheimer's disease (AD) and in the cerebrospinal fluid of individuals presenting mild cognitive impairment, is thought to be one of the major factors resulting in...
Kenneth S Henry et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 41(1), 118-129 (2020-11-13)
Loss of auditory-nerve (AN) afferent cochlear innervation is a prevalent human condition that does not affect audiometric thresholds and therefore remains largely undetectable with standard clinical tests. AN loss is widely expected to cause hearing difficulties in noise, known as...
Maria Sara Remedi et al.
PLoS medicine, 5(10), e206-e206 (2008-10-31)
Pancreatic beta-cell ATP-sensitive potassium (K ATP) channels are critical links between nutrient metabolism and insulin secretion. In humans, reduced or absent beta-cell K ATP channel activity resulting from loss-of-function K ATP mutations induces insulin hypersecretion. Mice with reduced K ATP...
Barbara Zonta et al.
Neuron, 69(5), 945-956 (2011-03-09)
The axon initial segment (AIS) is critical for the initiation and propagation of action potentials. Assembly of the AIS requires interactions between scaffolding molecules and voltage-gated sodium channels, but the molecular mechanisms that stabilize the AIS are poorly understood. The...
Nathalia Carolina Fernandes Fagundes et al.
PloS one, 13(7), e0200467-e0200467 (2018-07-14)
This systematic review and meta-analysis (MA) aimed to verify the capacity of different storage media to preserve viability of periodontal ligament cells in comparison to Hank's Balanced Salt Solution. The searches, selection process, data extraction and Risk of Bias control...
Maria Daniela Vlad et al.
Materials science & engineering. C, Materials for biological applications, 110, 110658-110658 (2020-03-25)
Titanium alloy scaffolds with novel interconnected and non-periodic porous bone-like micro architecture were 3D-printed and filled with hydroxyapatite bioactive matrix. These novel metallic-ceramic hybrid scaffolds were tested in vitro by direct-contact osteoblast cell cultures for cell adhesion, proliferation, morphology and...
Online oxygen monitoring using integrated inkjet-printed sensors in a liver-on-a-chip system
Moya A, et al.
Lab on a chip, 18, 2023-2035 (2018)
J Robert Lane et al.
eLife, 9 (2020-01-28)
By analyzing and simulating inactive conformations of the highly homologous dopamine D2 and D3 receptors (D2R and D3R), we find that eticlopride binds D2R in a pose very similar to that in the D3R/eticlopride structure but incompatible with the D2R/risperidone...
Vladimir Benes et al.
Scientific reports, 5, 11590-11590 (2015-06-26)
microRNAs are an abundant class of small non-coding RNAs that control gene expression post-transcriptionally. Importantly, microRNA activity participates in the regulation of cellular processes and is a potentially valuable source of biomarkers in the diagnosis and prognosis of human diseases....
Bailey G Hannon et al.
Experimental eye research, 202, 108354-108354 (2020-11-11)
Most animal models of glaucoma rely on induction of ocular hypertension (OHT), yet such models can suffer from high IOPs leading to undesirable retinal ischemia. Thus, animals with IOPs exceeding a threshold (e.g. > 60 mmHg) are often excluded from studies. However, due...
Susanna Sforzini et al.
Ecotoxicology and environmental safety, 138, 298-308 (2017-01-14)
Chromium (Cr) is one of the major and most detrimental pollutant, widely present in the environment as a result of several anthropogenic activities. In mammalian cells, Cr(VI) is known to enhance reactive oxygen species (ROS) production and to cause toxic...
Craig A Lygate et al.
Cardiovascular research, 96(3), 466-475 (2012-08-24)
Increasing energy storage capacity by elevating creatine and phosphocreatine (PCr) levels to increase ATP availability is an attractive concept for protecting against ischaemia and heart failure. However, testing this hypothesis has not been possible since oral creatine supplementation is ineffectual...
Benjamin R Fadl et al.
Molecular vision, 26, 705-717 (2020-10-23)
Single-cell RNA sequencing (scRNA-seq) is a powerful technique used to explore gene expression at the single cell level. However, appropriate preparation of samples is essential to obtain the most information out of this transformative technology. Generating high-quality single-cell suspensions from...
Hank s balanced salt solution: an alternative resuspension medium to label autologous leukocytes. Experience in inflammatory bowel disease
Martin-Comin J, et al.
Brazilian Archives of Biology and Technology, 45, 39-44 (2002)
Chelsea Hepler et al.
eLife, 7 (2018-09-29)
White adipose tissue (WAT) remodeling is dictated by coordinated interactions between adipocytes and resident stromal-vascular cells; however, the functional heterogeneity of adipose stromal cells has remained unresolved. We combined single-cell RNA-sequencing and FACS to identify and isolate functionally distinct subpopulations...
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