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Showing 1-18 of 18 results for "h9539" within Papers
Qian Kong et al.
Cancer biology & therapy, 21(4), 320-331 (2020-01-14)
High mobility group box protein 1 (HMGB1) is an evolutionarily conserved non-histone chromatin-binding protein. In a previous study, we showed that treating leukemic cells with chemotherapeutic drugs leads to the translocation of HMGB1, which is involved in autophagy and ultimately
Saumya Bhagat et al.
Blood cells, molecules & diseases, 84, 102459-102459 (2020-06-20)
Sterile Inflammation (SI), a condition where damage associated molecular patterns (DAMPs) released from dying cells, leads to TLR (Toll-like receptor) activation and triggers hypoxemia in circulation leading to venous thrombosis (VT) through tissue factor (TF) activation, but its importance under
Bandana Singh et al.
European journal of immunology, 46(10), 2388-2400 (2016-08-03)
Increased plasma level of von Willebrand Factor (vWF) is associated with major cardiovascular diseases. We previously reported that multimeric vWF binds to NO synthase and inhibits insulin-induced production of NO, thus promoting insulin resistance during acute hypoxia (AH). However, the
Yunyao Li et al.
Oncology letters, 19(1), 368-378 (2020-01-04)
Acute lymphoblastic leukaemia (ALL) is one of the most common and curable types of cancer in paediatric patients. However, chemotherapeutic resistance is a difficult but common obstacle when treating leukaemia in the clinical setting. Studies have demonstrated that drug resistance
Tianle Sun et al.
Immunology and cell biology, 101(8), 735-745 (2023-05-31)
Coxsackievirus B3 (CVB3)-induced viral myocarditis (VMC) is characterized by immune cell infiltration and myocardial damage. High mobility group box 1 (HMGB1) is a highly conserved nuclear DNA-binding protein that participates in DNA replication, transcriptional regulation, repair response and inflammatory response
Anjan K Bongoni et al.
Transplantation direct, 5(4), e341-e341 (2019-04-18)
Complement activation plays an important role in the pathogenesis of renal ischemia-reperfusion (IR) injury (IRI), but whether this involves damage to the vasculoprotective endothelial glycocalyx is not clear. We investigated the impact of complement activation on glycocalyx integrity and renal
Toll-like receptor 4 gene polymorphism influences dendritic cell
in vitro function and clinical outcomes in vaccinated melanoma
patients
in vitro function and clinical outcomes in vaccinated melanoma
patients
Andre's Tittarelli, et al.
Cancer Immunology, Immunotherapy (2012)
Israr Ahmad et al.
The European respiratory journal, 58(6) (2021-05-30)
We investigated the mechanisms by which N1-(β-d-ribofuranosyl)-5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), an activator of AMP-activated protein kinase (AMPK), decreases lung injury and mortality when administered to mice post exposure to bromine gas (Br2). We exposed male C57BL/6 mice and heme oxygenase-1 (HO-1)-deficient
Yu Qiu et al.
Journal of cellular and molecular medicine, 25(17), 8244-8260 (2021-08-20)
Septic cardiomyopathy is a common complication of sepsis with high morbidity and mortality, but lacks specific therapy. This study aimed to reveal the role of circTLK1 and its potential mechanisms in septic cardiomyopathy. The in vitro and in vivo models
Shengye Zhang et al.
Journal of vascular surgery, 68(6S), 209S-221S (2018-02-06)
Ischemia-reperfusion (I/R) injury is a major clinical problem linked to vascular surgery. Currently, no drugs to prevent or to treat I/R injury are approved for clinical use. C1 inhibitor (C1 INH) is known to reduce activation of the plasma cascade
MiR-142-3p functions as a potential tumor suppressor directly targeting HMGB1 in non-small-cell lung carcinoma.
Xiao P and Liu WL
International Journal of Clinical and Experimental Pathology (2015)
Qingyun Peng et al.
International journal of biological sciences, 16(15), 2974-2988 (2020-10-17)
Sepsis-induced myocardial dysfunction (SIMD) is a life-threatening complication caused by inflammation, but how it is initiated is still unclear. Several studies have shown that extracellular high mobility group box 1 (HMGB1), an important cytokine triggering inflammation, is overexpressed during the
HMGB1 facilitates hypoxia-induced vWF upregulation through TLR2-MYD88-SP1 pathway
Bandana Singh, et al.
European Journal of Immunology (2016)
Shengye Zhang et al.
Bone, 97, 278-286 (2017-02-06)
Ischemia/reperfusion (I/R) injury has been extensively studied in organs such as heart, brain, liver, kidney, and lung. As a vascularized organ, bone is known to be susceptible to I/R injury too, but the respective mechanisms are not well understood to
Ross Pirnie et al.
Chemical research in toxicology, 35(10), 1893-1902 (2022-08-04)
The high mobility group box 1 (HMGB1), which is released during acute acetaminophen (APAP) overdose, is thought to mediate a subsequent immune response, particularly hepatic infiltration of macrophages. The redox behavior of HMGB1 and the proteoforms of HMGB1 present in
Ronghua Wu et al.
Cell death & disease, 10(6), 417-417 (2019-05-30)
SAM and SH3 domain-containing 1 (SASH1), a scaffold protein, is regarded as a tumor suppressor. Recent studies have verified the decreased expression of SASH1 in many tumors. Our previous clinical investigation found that SASH1 was widely expressed in normal brain
Ofir Meir et al.
PloS one, 5(3), e9516-e9516 (2010-03-09)
Endoplasmic reticulum (ER) stress elicits the unfolded protein response (UPR), initially aimed at coping with the stress, but triggering cell death upon further stress. ER stress induces the C/EBP-beta variant Liver-enriched Activating Protein (LAP), followed by the dominant-negative variant, Liver
Liwei Weng et al.
Analytical chemistry, 90(12), 7552-7560 (2018-05-24)
High mobility group box 1 (HMGB1) is a non-histone chromosomal protein, which can be secreted through a variety of pathways and bind to pattern recognition receptors to release pro-inflammatory cytokines. Previous studies have suggested that HMGB1 is upregulated in numerous
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