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Ovarian carcinoma immunoreactive antigen-like protein 2 (OCIAD2) is a novel complex III-specific assembly factor in mitochondria.

Katarzyna Justyna Chojnacka et al.

Molecular biology of the cell, 33(4), ar29-ar29 (2022-01-27)

Assembly of the dimeric complex III (CIII2) in the mitochondrial inner membrane is an intricate process in which several accessory proteins are involved as assembly factors. Despite numerous studies, this process has yet to be fully understood. Here we report

C11orf83, a mitochondrial cardiolipin-binding protein involved in bc1 complex assembly and supercomplex stabilization.

Marjorie Desmurs et al.

Molecular and cellular biology, 35(7), 1139-1156 (2015-01-22)

Mammalian mitochondria may contain up to 1,500 different proteins, and many of them have neither been confidently identified nor characterized. In this study, we demonstrated that C11orf83, which was lacking experimental characterization, is a mitochondrial inner membrane protein facing the

NDUFAF5 Hydroxylates NDUFS7 at an Early Stage in the Assembly of Human Complex I.

Virginie F Rhein et al.

The Journal of biological chemistry, 291(28), 14851-14860 (2016-05-27)

Complex I (NADH ubiquinone oxidoreductase) in mammalian mitochondria is an L-shaped assembly of 45 proteins. One arm lies in the inner membrane, and the other extends about 100 Å into the matrix of the organelle. The extrinsic arm contains binding

Inhibition of proteasome rescues a pathogenic variant of respiratory chain assembly factor COA7.

Karthik Mohanraj et al.

EMBO molecular medicine, 11(5) (2019-03-20)

Nuclear and mitochondrial genome mutations lead to various mitochondrial diseases, many of which affect the mitochondrial respiratory chain. The proteome of the intermembrane space (IMS) of mitochondria consists of several important assembly factors that participate in the biogenesis of mitochondrial

Proteomic analysis of mitochondria-to-nucleus retrograde response in human cancer.

Mariola Kulawiec et al.

Cancer biology & therapy, 5(8), 967-975 (2006-06-16)

All tumors examined to date contain mutations in mitochondrial DNA (mtDNA). In addition, depletion of mtDNA is reported in a variety of tumors. Mitochondrial dysfunction resulting from changes in mtDNA invokes mitochondria-to-nucleus retrograde response in human cells. To identify proteins

Integration of cardiac proteome biology and medicine by a specialized knowledgebase.

Nobel C Zong et al.

Circulation research, 113(9), 1043-1053 (2013-08-24)

Omics sciences enable a systems-level perspective in characterizing cardiovascular biology. Integration of diverse proteomics data via a computational strategy will catalyze the assembly of contextualized knowledge, foster discoveries through multidisciplinary investigations, and minimize unnecessary redundancy in research efforts. The goal

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