Showing 1-7 of 7 results for "HPA003222"
Yi Lin et al.
Journal of surgical oncology, 106(7), 880-886 (2012-05-16)
Protein tyrosine kinase 7 (PTK7) plays important functions in several cancer types but its expression in gastric cancer remains unknown. This study was designed to investigate PTK7 expression in gastric cancer. PTK7 expression was assessed by immunohistochemistry in 201 gastric...
Vladislav S Golubkov et al.
The Journal of biological chemistry, 289(35), 24238-24249 (2014-07-10)
It is well established that widely expressed PTK7 is essential for vertebrate tissue morphogenesis. In cancer, the functionality of PTK7 is selectively regulated by membrane type-1 matrix metalloproteinase (MT1-MMP), ADAMs (a disintegrin domain and metalloproteinases), and γ-secretase proteolysis. Here, we...
Iryna Shnitsar et al.
Development (Cambridge, England), 135(24), 4015-4024 (2008-11-14)
PTK7 regulates planar cell polarity (PCP) signaling during vertebrate neural tube closure and establishment of inner ear hair cell polarity; however, its signaling mechanism is unknown. Here, we demonstrate a new function for PTK7 in Xenopus neural crest migration and...
Beyhan Ataseven et al.
Anticancer research, 33(9), 3759-3763 (2013-09-12)
Protein tyrosine kinase-7 (PTK7) plays an important role in cancer. Our aim was to evaluate PTK7 in triple-negative breast cancer (TNBC). PTK7 Expression was assessed by immunohistochemistry (IHC) in 133 patients with TNBC. Expression levels were correlated with clinicopathological features...
A meta-analysis of lung cancer gene expression identifies PTK7 as a survival gene in lung adenocarcinoma.
Chen R, Khatri P, Mazur PK, et al.
Cancer Research, 74(10), 2892-2902 (2014)
Xiaowei Lu et al.
Nature, 430(6995), 93-98 (2004-07-02)
In addition to the apical-basal polarity pathway operating in epithelial cells, a planar cell polarity (PCP) pathway establishes polarity within the plane of epithelial tissues and is conserved from Drosophila to mammals. In Drosophila, a 'core' group of PCP genes...
Silvia Gärtner et al.
PloS one, 9(1), e84472-e84472 (2014-01-11)
Protein Tyrosin Kinase 7 (PTK7) is upregulated in several human cancers; however, its clinical implication in breast cancer (BC) and lymph node (LN) is still unclear. In order to investigate the function of PTK7 in mediating BC cell motility and...

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