Showing 1-30 of 87 results for "HPA004252"
David Verhoeven et al.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 59(3), 376-383 (2014-05-03)
Acute otitis media (AOM) is a leading cause of bacterial pediatric infections associated with viral upper respiratory infections (URIs). We examined the differential impact of respiratory syncytial virus (RSV) and parainfluenza virus URIs on the frequency of AOM caused by...
Satoru Watanabe et al.
Acta haematologica, 133(1), 83-88 (2014-08-30)
In some previous studies, vitamin B12 treatment showed immunomodulatory effects and restored the immunological abnormalities in patients with pernicious anemia (PA). In the present study, peripheral blood T cell subsets, including regulatory T cells (T(reg)s), were examined before and after...
S Chinnapaiyan et al.
Scientific reports, 8(1), 7984-7984 (2018-05-24)
Recurrent lung infections are a common cause of morbidity and mortality in people living with HIV and this is exacerbated in smokers even when administered combination antiretroviral therapy (cART). The incidence of pneumonia is increased with smoking and treatment interruption...
Daniel S Shin et al.
EMBO reports, 15(9), 991-999 (2014-07-31)
Regulatory T cells (Tregs) control autoreactive T cells by inhibiting activation-induced proliferation and cytokine expression. The molecular mechanisms responsible for the inactivation of effector T cells by Tregs remain yet to be fully characterized. We report that T-helper cells stimulated...
Julie Lajoie et al.
The Journal of infectious diseases, 210(2), 319-329 (2014-01-15)
Unprotected intercourse and seminal discharge are powerful activators of the mucosal immune system and are important risk factors for transmission of human immunodeficiency virus (HIV). This study was designed to determine if female sex work is associated with changes in...
J Pieper et al.
Scandinavian journal of immunology, 79(2), 149-155 (2013-12-10)
Proinflammatory CD4(+) CD28(null) T cells are frequently found in the circulation of patients with rheumatoid arthritis (RA), but are less common in the rheumatic joint. In the present study, we sought to identify functional differences between CD4(+) CD28(null) T cells...
Alejandro E Ramirez et al.
Transplant international : official journal of the European Society for Organ Transplantation, 27(9), 977-986 (2014-05-28)
Vascularized bone marrow transplantation (VBMT) appears to promote tolerance for vascularized composite allotransplantation (VCA). However, it is unclear whether VBMT is critical for tolerance induction and, if so, whether there is a finite amount of VCA that VBMT can support....
Koichi Iwanaga et al.
Cancer research, 74(11), 3011-3019 (2014-06-01)
Compared with prostaglandin E2, which has an established role in cancer, the role of the COX metabolite prostaglandin D2 (PGD2) in chronic inflammation leading to tumorigenesis is uncertain. In this study, we investigated the role of PGD2 in colitis and...
Tim Hutten et al.
Journal of immunotherapy (Hagerstown, Md. : 1997), 37(5), 267-277 (2014-05-09)
Autologous, patient-specific, monocyte-derived dendritic cell (MoDC) vaccines have been successfully applied in the clinical studies so far. However, the routine application of this strategy has been hampered by the difficulties in generating sufficient numbers of DC and the poor DC...
N Puebla-Osorio et al.
Oncogene, 33(21), 2748-2757 (2013-06-12)
Ku70, a known nonhomologous end-joining (NHEJ) factor, also functions in tumor suppression, although this molecular mechanism remains uncharacterized. Previously, we showed that mice deficient for DNA ligase IV (Lig4), another key NHEJ factor, succumbed to aggressive lymphoma in the absence...
Javier Vega-Ramos et al.
Journal of immunology (Baltimore, Md. : 1950), 193(8), 3851-3859 (2014-09-10)
Dendritic cells (DCs) are directly activated by pathogen-associated molecular patterns (PAMPs) and undergo maturation. Mature DCs express high levels of MHC class II molecules ("signal 1"), upregulate T cell costimulatory receptors ("signal 2"), and secrete "signal 3" cytokines (e.g., IL-12)....
Caroline Aspord et al.
European journal of immunology, 44(10), 2880-2892 (2014-07-22)
Robust cell-mediated immunity is required for immune control of tumours and protection from viral infections, with both CD4(+) and CD8(+) T cells playing a pivotal role. Synthetic long peptides (SLPs) represent an attractive way to induce such combined responses, as...
Qiangjun Sui et al.
Journal of immunology (Baltimore, Md. : 1950), 193(4), 2016-2023 (2014-07-13)
STAT3 is highly activated in a wide variety of cancers and functions to promote tumor survival. We previously reported that blocking STAT3 activation inhibited human hepatocellular carcinoma (HCC) growth in vitro, but whether this treatment also triggered antitumor immune responses...
Ina Rosenberger et al.
Journal of controlled release : official journal of the Controlled Release Society, 194, 130-137 (2014-09-01)
Iron oxide-containing magnetic nanoparticles (MNPs) have certain advantages over currently used contrast agents for tumor imaging by magnetic resonance imaging (MRI) as they offer the possibility of functionalization with ligands and tracers. Functionalized MNPs also may be used for targeted...
Johanna Breuer et al.
Annals of neurology, 75(5), 739-758 (2014-04-29)
Environmental conditions (eg, latitude) play a critical role in the susceptibility and severity of many autoimmune disorders, including multiple sclerosis (MS). Here, we investigated the mechanisms underlying the beneficial effects of immune regulatory processes induced in the skin by moderate...
Daisuke Ishii et al.
Journal of immunology (Baltimore, Md. : 1950), 193(7), 3816-3824 (2014-08-31)
Recipient CD4 T regulatory cells inhibit the acute T cell-mediated rejection of renal allografts in wild-type mice. The survival of single class II MHC-disparate H-2(bm12) renal allografts was tested in B6.CCR5(-/-) recipients, which have defects in T regulatory cell activities...
Joseph M Cantor
Journal of neuroimmunology, 274(1-2), 230-233 (2014-07-09)
Current B cell-directed therapies for multiple sclerosis impact multiple B cell functions. CD98hc enables B cell clonal expansion and antibody production. I probed the relative importance of autoantibody secretion vs. other B cell functions in MS and targeted CD98hc as...
Zhiwu Tan et al.
Cancer research, 74(21), 6010-6021 (2014-08-16)
Eradicating malignant tumors by vaccine-elicited host immunity remains a major medical challenge. To date, correlates of immune protection remain unknown for malignant mesothelioma. In this study, we demonstrated that antigen-specific CD8(+) T-cell immune response correlates with the elimination of malignant...
Mirelle J A J Huijskens et al.
Journal of leukocyte biology, 96(6), 1165-1175 (2014-08-27)
The efficacy of donor HSCT is partly reduced as a result of slow post-transplantation immune recovery. In particular, T cell regeneration is generally delayed, resulting in high infection-related mortality in the first years post-transplantation. Adoptive transfer of in vitro-generated human...
Kouichi Furugaki et al.
PloS one, 9(7), e101854-e101854 (2014-07-12)
Polyplex micelles have demonstrated biocompatibility and achieve efficient gene transfection in vivo. Here, we investigated a polyplex micelle encapsulating genes encoding the tumor-associated antigen squamous cell carcinoma antigen recognized by T cells-3 (SART3), adjuvant CD40L, and granulocyte macrophage colony-stimulating factor...
Lingjun Zhang et al.
Investigative ophthalmology & visual science, 55(9), 5561-5571 (2014-08-16)
We tested the long-term effects of different regimens of mesenchymal stem cell (MSC) administration in a recurrent experimental autoimmune uveitis (rEAU) model in rats, and compared the efficacy of MSC to that of dexamethasone (DEX). One or two courses of...
Paula Cristina Batista de Faria et al.
Nano letters, 14(9), 5458-5470 (2014-08-15)
Properties like high interfacial area with cellular membranes, unique ability to incorporate multiple functionalization, as well as compatibility and transport in biological fluids make carbon nanotubes (CNTs) useful for a variety of therapeutic and drug-delivery applications. Here we used a...
Géraldine Arrode-Brusés et al.
PloS one, 9(10), e110883-e110883 (2014-10-23)
Prevention of HIV acquisition and replication requires long lasting and effective immunity. Given the state of HIV vaccine development, innovative vectors and immunization strategies are urgently needed to generate safe and efficacious HIV vaccines. Here, we developed a novel lentivirus-based...
Ornella Parolini et al.
Arthritis & rheumatology (Hoboken, N.J.), 66(2), 327-339 (2014-02-08)
Rheumatoid arthritis (RA) is an autoimmune disease caused by loss of immunologic self tolerance and characterized by chronic joint inflammation. Cells isolated from human amniotic membrane (HAMCs) were recently found to display immunosuppressive properties. The aim of this study was...
Arnold Han et al.
Nature biotechnology, 32(7), 684-692 (2014-06-24)
Although each T lymphocyte expresses a T-cell receptor (TCR) that recognizes cognate antigen and controls T-cell activation, different T cells bearing the same TCR can be functionally distinct. Each TCR is a heterodimer, and both α- and β-chains contribute to...
Peggy P Ni et al.
Journal of immunology (Baltimore, Md. : 1950), 193(4), 1778-1786 (2014-07-13)
Thymic selection is designed to ensure TCR reactivity to foreign Ags presented by self-MHC while minimizing reactivity to self-Ags. We hypothesized that the repertoire of T cells with unwanted specificities such as alloreactivity or autoreactivity are a consequence of simultaneous...
Bernet S Kato et al.
Proteome science, 9, 73-73 (2011-11-19)
The advent of affinity-based proteomics technologies for global protein profiling provides the prospect of finding new molecular biomarkers for common, multifactorial disorders. The molecular phenotypes obtained from studies on such platforms are driven by multiple sources, including genetic, environmental, and...
J Michelle Kahlenberg et al.
Arthritis & rheumatology (Hoboken, N.J.), 66(1), 152-162 (2014-01-23)
Systemic lupus erythematosus (SLE) is a systemic autoimmune syndrome associated with organ damage and an elevated risk of cardiovascular disease resulting from activation of both innate and adaptive immune pathways. Recently, increased activation of the inflammasome machinery in SLE has...
Xinxin Wang et al.
Science signaling, 7(337), ra74-ra74 (2014-08-07)
Precise regulation of the kinetics and magnitude of Ca(2+) signaling enables this signal to mediate diverse responses, such as cell migration, differentiation, vesicular trafficking, and cell death. We showed that the Ca(2+)-binding protein calmodulin (CaM) acted in a positive feedback...
Alex F Herrera et al.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 20(11), 1737-1743 (2014-07-16)
Chronic graft-versus-host disease (GVHD) induces significant morbidity and mortality after allogeneic hematopoietic stem cell transplantation. Corticosteroids are standard initial therapy, despite limited efficacy and long-term toxicity. Based on our experience using bortezomib as effective acute GVHD prophylaxis, we hypothesized that...

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