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Showing 1-7 of 7 results for "hpa005689" within Papers
V Yankiwski et al.
Proceedings of the National Academy of Sciences of the United States of America, 97(10), 5214-5219 (2000-04-26)
Bloom syndrome (BS) is a rare cancer-predisposing disorder in which the cells of affected persons have a high frequency of somatic mutation and genomic instability. BLM, the protein altered in BS, is a RecQ DNA helicase. This report shows that
Laura V Croft et al.
BMC molecular biology, 18(1), 13-13 (2017-05-17)
Maintenance of genome stability is critical in human cells. Mutations in or loss of genome stability pathways can lead to a number of pathologies including cancer. hSSB1 is a critical DNA repair protein functioning in the repair and signalling of
Suruchika Chandra et al.
Journal of cell science, 126(Pt 16), 3782-3795 (2013-06-12)
The spectrum of tumors that arise owing to the overexpression of c-Myc and loss of BLM is very similar. Hence, it was hypothesized that the presence of BLM negatively regulates c-Myc functions. By using multiple isogenic cell lines, we observed
Cayetano von Kobbe et al.
The Journal of biological chemistry, 277(24), 22035-22044 (2002-03-29)
The RecQ helicase family comprises a conserved group of proteins implicated in several aspects of DNA metabolism. Three of the family members are defective in heritable diseases characterized by abnormal growth, premature aging, and predisposition to malignancies. These include the
Jitendra K Meena et al.
The EMBO journal, 34(10), 1371-1384 (2015-03-31)
The causal role of aneuploidy in cancer initiation remains under debate since mutations of euploidy-controlling genes reduce cell fitness but aneuploidy strongly associates with human cancers. Telomerase activation allows immortal growth by stabilizing telomere length, but its role in aneuploidy
N A Ellis et al.
Cell, 83(4), 655-666 (1995-11-17)
The Bloom's syndrome (BS) gene, BLM, plays an important role in the maintenance of genomic stability in somatic cells. A candidate for BLM was identified by direct selection of a cDNA derived from a 250 kb segment of the genome
Victoria Valinluck Lao et al.
Translational oncology, 6(4), 458-469 (2013-08-03)
Deregulation of DNA repair enzymes occurs in cancers and may create a susceptibility to chemotherapy. Expression levels of DNA repair enzymes have been shown to predict the responsiveness of cancers to certain chemotherapeutic agents. The RECQ helicases repair damaged DNA
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