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Viktoria Konya et al.
The Journal of allergy and clinical immunology, 131(2), 532-540 (2012-06-19)
Increased vascular permeability is a fundamental characteristic of inflammation. Substances that are released during inflammation, such as prostaglandin (PG) E(2), can counteract vascular leakage, thereby hampering tissue damage. In this study we investigated the role of PGE(2) and its receptors...
Malak Haidar et al.
Infection and immunity, 83(5), 1869-1880 (2015-02-19)
Transforming growth factor beta (TGF-β) is a pleiotropic cytokine known to regulate cell growth, differentiation, and motility and is a potent modulator of immune function. TGF-β consequently plays a central role in carcinogenesis, and a dampened TGF-β2 response by Theileria...
Nami Shrestha Palikhe et al.
Journal of human genetics, 57(8), 494-499 (2012-06-15)
Prostaglandin E2 receptor subtype EP4 (PTGER4) is one of the four subtypes of receptors for prostaglandin E2 (PGE2). Overproduction of cysteinyl leukotriene in mast cells may be related with suppression of PGE2 in patients with aspirin hypersensitivity. Considering the association...
Tomoyasu Nishimura et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(9), 3827-3836 (2013-06-14)
Prostaglandin E2 (PGE2) is an important biological mediator involved in the defense against Mycobacterium tuberculosis (Mtb) infection. Previously, we reported that in macrophages (Mϕs), infection with avirulent Mtb H37Ra resulted in inhibition of necrosis by an inhibitory effect on mitochondrial...
Jürgen Glas et al.
PloS one, 7(12), e52873-e52873 (2013-01-10)
Genome-wide association studies identified a PTGER4 expression-modulating region on chromosome 5p13.1 as Crohn's disease (CD) susceptibility region. The study aim was to test this association in a large cohort of patients with inflammatory bowel disease (IBD) and to elucidate genotypic...
Matthias Prager et al.
International journal of colorectal disease, 29(8), 909-915 (2014-05-06)
Variants modulating expression of the prostaglandin receptor 4 (PTGER4) have been reported to be associated with Cohn's disease (CD), but the clinical impact remains to be elucidated. We analyzed these variants in a large German inflammatory bowel disease (IBD) cohort...
Sonia Philipose et al.
Arteriosclerosis, thrombosis, and vascular biology, 30(12), 2416-2423 (2010-11-13)
Low concentrations of prostaglandin (PG) E(2) enhance platelet aggregation, whereas high concentrations inhibit it. The effects of PGE(2) are mediated through 4 G protein-coupled receptors, termed E-type prostaglindin (EP) receptor EP1, EP2, EP3, and EP4. The platelet-stimulating effect of PGE(2)...