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HPA014518

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Gloriia Novikova et al.
Nature communications, 12(1), 1610-1610 (2021-03-14)
Genome-wide association studies (GWAS) have identified more than 40 loci associated with Alzheimer's disease (AD), but the causal variants, regulatory elements, genes and pathways remain largely unknown, impeding a mechanistic understanding of AD pathogenesis. Previously, we showed that AD risk
Ghosts in the shell: identification of microglia in the human central nervous system by P2Y12 receptor.
Mildner A.
Neural Regeneration Research, 12(4), 570?571-570?571 (2017)
Amanda McQuade et al.
Molecular neurodegeneration, 13(1), 67-67 (2018-12-24)
Microglia, the principle immune cells of the brain, play important roles in neuronal development, homeostatic function and neurodegenerative disease. Recent genetic studies have further highlighted the importance of microglia in neurodegeneration with the identification of disease risk polymorphisms in many
Ghosts in the shell: identification of microglia in the human central nervous system by P2Y12 receptor.
Alexander Mildner
Neural regeneration research, 12(4), 570-571 (2017-05-30)
Sensory Experience Engages Microglia to Shape Neural Connectivity through a Non-Phagocytic Mechanism.
Cheadle, et al.
Neuron, 108, 451-468 (2021)
Comparative analysis of human microglial models for studies of HIV replication and pathogenesis.
Rai, et al.
Retrovirology, 17, 35-35 (2021)
The ADP receptor P2RY12 regulates osteoclast function and pathologic bone remodeling.
Su X, et al.
The Journal of Clinical Investigation, 122(10), 3579-3592 (2012)
Douglas G Walker et al.
International journal of molecular sciences, 21(2) (2020-01-24)
Neuroinflammation is considered a key pathological process in neurodegenerative diseases of aging, including Alzheimer's disease (AD). Many studies have defined phenotypes of reactive microglia, the brain-resident macrophages, with different antigenic markers to identify those potentially causing inflammatory damage. We took
Genomic landscape of megakaryopoiesis and platelet function defects.
Elisa B, et al.
Blood, 127, 1249-1259 (2016)
iPSC-derived human microglia-like cells to study neurological diseases.
Abud E M, et al.
Neuron, 94(2), 278-293 (2017)
Hisashi Akiyama et al.
Journal of virology (2020-12-11)
Chronic neuroinflammation is observed in HIV+ individuals on suppressive combination antiretroviral therapy (cART) and is thought to cause HIV-associated neurocognitive disorders. We have recently reported that expression of HIV intron-containing RNA (icRNA) in productively infected monocyte-derived macrophages induces pro-inflammatory responses.
Lindsay A Hohsfield et al.
Journal of neuroinflammation, 17(1), 279-279 (2020-09-22)
Microglia, the primary resident myeloid cells of the brain, play critical roles in immune defense by maintaining tissue homeostasis and responding to injury or disease. However, microglial activation and dysfunction has been implicated in a number of central nervous system
Diana G Bohannon et al.
Brain pathology (Zurich, Switzerland), 30(3), 603-613 (2019-12-14)
We previously showed that rhesus macaques neonatally infected with simian immunodeficiency virus (SIV) do not develop SIV encephalitis (SIVE) and maintain low brain viral loads despite having similar plasma viral loads compared to SIV-infected adults. We hypothesize that differences in
Renzo Mancuso et al.
Nature neuroscience, 22(12), 2111-2116 (2019-10-30)
Although genetics highlights the role of microglia in Alzheimer's disease, one-third of putative Alzheimer's disease risk genes lack adequate mouse orthologs. Here we successfully engraft human microglia derived from embryonic stem cells in the mouse brain. The cells recapitulate transcriptionally
Molly E V Swanson et al.
Scientific reports, 10(1), 11693-11693 (2020-07-18)
Current immunohistochemical methods of studying microglia in the post-mortem human brain do not capture the heterogeneity of microglial function in response to damage and disease. We therefore investigated the expression of eight myeloid cell proteins associated with changes in function
Ticagrelor yields consistent dose-dependent inhibition of ADP-induced platelet aggregation in patients with atherosclerotic disease regardless of genotypic variations in P2RY12, P2RY1, and ITGB3.
Storey R F, et al.
Platelets, 20(5), 341-348 (2009)
Wenxin Ma et al.
eLife, 8 (2019-01-23)
Constitutive TGFβ signaling is important in maintaining retinal neurons and blood vessels and is a factor contributing to the risk for age-related macular degeneration (AMD), a retinal disease involving neurodegeneration and microglial activation. How TGFβ signaling to microglia influences pathological
Genome-wide linkage and positional candidate gene study of blood pressure response to dietary potassium intervention: the genetic epidemiology network of salt sensitivity study.
Kelly T N, et al.
Circulation: Genomic and Precision Medicine, 3(6), 539-547 (2010)
Lindsay A Hohsfield et al.
eLife, 10 (2021-08-24)
Microglia, the brain's resident myeloid cells, play central roles in brain defense, homeostasis, and disease. Using a prolonged colony-stimulating factor 1 receptor inhibitor (CSF1Ri) approach, we report an unprecedented level of microglial depletion and establish a model system that achieves
Expression site of P2RY12 in residential microglial cells in astrocytomas correlates with M1 and M2 marker expression and tumor grade.
Zhu C, et al.
Acta Neuropathologica Communications, 5(1), 4-4 (2017)
Anaelle A Dumas et al.
The EMBO journal, 39(15), e103790-e103790 (2020-06-23)
Tumour-associated microglia/macrophages (TAM) are the most numerous non-neoplastic populations in the tumour microenvironment in glioblastoma multiforme (GBM), the most common malignant brain tumour in adulthood. The mTOR pathway, an important regulator of cell survival/proliferation, is upregulated in GBM, but little
Giovanni Di Liberto et al.
Cell, 175(2), 458-471 (2018-09-04)
Inflammatory disorders of the CNS are frequently accompanied by synaptic loss, which is thought to involve phagocytic microglia and complement components. However, the mechanisms accounting for aberrant synaptic connectivity in the context of CD8+ T cell-driven neuronal damage are poorly understood.
Jannis Wißfeld et al.
Scientific reports, 11(1), 13462-13462 (2021-07-01)
CD33/Sialic acid-binding Ig-like lectin 3 (SIGLEC3) is an innate immune receptor expressed on myeloid cells and mediates inhibitory signaling via tyrosine phosphatases. Variants of CD33 are associated with Alzheimer's disease (AD) suggesting that modulation of CD33 signaling might be beneficial
Edsel M Abud et al.
Neuron, 94(2), 278-293 (2017-04-21)
Microglia play critical roles in brain development, homeostasis, and neurological disorders. Here, we report that human microglial-like cells (iMGLs) can be differentiated from iPSCs to study their function in neurological diseases, like Alzheimer's disease (AD). We find that iMGLs develop
Alessandro Venturino et al.
Cell reports, 36(1), 109313-109313 (2021-07-08)
Perineuronal nets (PNNs), components of the extracellular matrix, preferentially coat parvalbumin-positive interneurons and constrain critical-period plasticity in the adult cerebral cortex. Current strategies to remove PNN are long-lasting, invasive, and trigger neuropsychiatric symptoms. Here, we apply repeated anesthetic ketamine as
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