hpa022904

" within Papers

Dual localization of glutathione S-transferase in the cytosol and mitochondria: implications in oxidative stress, toxicity and disease

Raza H

FEBS Journal, 278(22), 4243-4251 (2011)

Polymorphisms in the human glutathione transferase Kappa (GSTK1) promoter alter gene expression.

Alison J Shield et al.

Genomics, 95(5), 299-305 (2010-03-03)

The level of glutathione transferase Kappa (GSTK1-1) has been correlated with obesity (Liu et.al. 2008 PNAS 105: 18302-7) and a polymorphism in the hGSTK1 promoter has been associated with insulin secretion and fat deposition (Gao et al 2009 Endocr J

Modelling and bioinformatics studies of the human Kappa-class glutathione transferase predict a novel third glutathione transferase family with similarity to prokaryotic 2-hydroxychromene-2-carboxylate isomerases.

Anna Robinson et al.

The Biochemical journal, 379(Pt 3), 541-552 (2004-01-08)

The Kappa class of GSTs (glutathione transferases) comprises soluble enzymes originally isolated from the mitochondrial matrix of rats. We have characterized a Kappa class cDNA from human breast. The cDNA is derived from a single gene comprising eight exons and

Growth hormone alters the glutathione S-transferase and mitochondrial thioredoxin systems in long-living Ames dwarf mice.

Lalida Rojanathammanee et al.

The journals of gerontology. Series A, Biological sciences and medical sciences, 69(10), 1199-1211 (2013-11-29)

Ames dwarf mice are deficient in growth hormone (GH), prolactin, and thyroid-stimulating hormone and live significantly longer than their wild-type (WT) siblings. The lack of GH is associated with stress resistance and increased longevity. However, the mechanism underlying GH's actions

Downregulation of GSTK1 is a common mechanism underlying hypertrophic cardiomyopathy

Sasagawa S, et al.

Frontiers in Pharmacology, 7, 162-162 (2016)

Gene and protein characterization of the human glutathione S-transferase kappa and evidence for a peroxisomal localization.

Fabrice Morel et al.

The Journal of biological chemistry, 279(16), 16246-16253 (2004-01-27)

Kappa class glutathione S-transferase (GST) cDNA sequences have been identified in rat, mouse, and human. In the present study, we determined the structure and chromosomal location of the human GST Kappa 1 (hGSTK1) gene, characterized the protein, and demonstrated its

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