hpa027398

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A heterologous in-cell assay for investigating intermicrovillar adhesion complex interactions reveals a novel protrusion length-matching mechanism.

Meredith L Weck et al.

The Journal of biological chemistry, 295(48), 16191-16206 (2020-10-15)

Solute transporting epithelial cells build arrays of microvilli on their apical surface to increase membrane scaffolding capacity and enhance function potential. In epithelial tissues such as the kidney and gut, microvilli are length-matched and assembled into tightly packed "brush borders,"

ANKS4B Is Essential for Intermicrovillar Adhesion Complex Formation.

Scott W Crawley et al.

Developmental cell, 36(2), 190-200 (2016-01-27)

Transporting and sensory epithelial cells shape apical specializations using protocadherin-based adhesion. In the enterocyte brush border, protocadherin function requires a complex of cytoplasmic binding partners, although the composition of this complex and logic governing its assembly remain poorly understood. We

Brush border protocadherin CDHR2 promotes the elongation and maximized packing of microvilli in vivo.

Julia A Pinette et al.

Molecular biology of the cell, 30(1), 108-118 (2018-11-08)

Transporting epithelial cells optimize their morphology for solute uptake by building an apical specialization: a dense array of microvilli that serves to increase membrane surface area. In the intestinal tract, individual cells build thousands of microvilli, which pack tightly to

The small EF-hand protein CALML4 functions as a critical myosin light chain within the intermicrovillar adhesion complex.

Myoung Soo Choi et al.

The Journal of biological chemistry, 295(28), 9281-9296 (2020-03-27)

Specialized transporting and sensory epithelial cells employ homologous protocadherin-based adhesion complexes to remodel their apical membrane protrusions into organized functional arrays. Within the intestine, the nutrient-transporting enterocytes utilize the intermicrovillar adhesion complex (IMAC) to assemble their apical microvilli into an

A cryptic sequence targets the adhesion complex scaffold ANKS4B to apical microvilli to promote enterocyte brush border assembly.

Maura J Graves et al.

The Journal of biological chemistry, 295(36), 12588-12604 (2020-07-09)

Nutrient-transporting enterocytes interact with their luminal environment using a densely packed collection of apical microvilli known as the brush border. Assembly of the brush border is controlled by the intermicrovillar adhesion complex (IMAC), a protocadherin-based complex found at the tips

Structure of Myo7b/USH1C complex suggests a general PDZ domain binding mode by MyTH4-FERM myosins.

Jianchao Li et al.

Proceedings of the National Academy of Sciences of the United States of America, 114(19), E3776-E3785 (2017-04-26)

Unconventional myosin 7a (Myo7a), myosin 7b (Myo7b), and myosin 15a (Myo15a) all contain MyTH4-FERM domains (myosin tail homology 4-band 4.1, ezrin, radixin, moesin; MF) in their cargo binding tails and are essential for the growth and function of microvilli and

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