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hpa053268

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Jun Ying et al.
Life sciences, 192, 84-90 (2017-11-22)
Transforming growth factor-β1 (TGF-β1) is a chondrogenic factor and has been reported to be able to enhance chondrocyte differentiation from bone marrow mesenchymal stem cells (BMSCs). Here we investigate the molecular mechanism through which TGF-β1 chronically promotes the repair of...
Shirou Tabe et al.
Scientific reports, 7(1), 16701-16701 (2017-12-03)
Glycerophospholipids have important structural and functional roles in cells and are the main components of cellular membranes. Glycerophospholipids are formed via the de novo pathway (Kennedy pathway) and are subsequently matured in the remodeling pathway (Lands' cycle). Lands' cycle consists...
Anika Wehrle et al.
JCI insight, 4(3) (2019-02-08)
Odontochondrodysplasia (ODCD) is an unresolved genetic disorder of skeletal and dental development. Here, we show that ODCD is caused by hypomorphic TRIP11 mutations, and we identify ODCD as the nonlethal counterpart to achondrogenesis 1A (ACG1A), the known null phenotype in...
Xiaomin Kang et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 35(7), 1375-1384 (2020-02-27)
Neuropeptide Y (NPY) is known to regulate bone homeostasis; however, its functional role as a risk factor during osteoarthritis (OA) remains elusive. In this study, we aim to investigate the direct effect of NPY on degradation of cartilage and progression...
Chao Zheng et al.
EBioMedicine, 40, 695-709 (2019-01-28)
Mutations in the SLC26A2 gene cause a spectrum of currently incurable human chondrodysplasias. However, genotype-phenotype relationships of SLC26A2-deficient chondrodysplasias are still perplexing and thus stunt therapeutic development. To investigate the causative role of SLC26A2 deficiency in chondrodysplasias and confirm its...
Weiqian Guo et al.
Journal of Cancer, 12(7), 1867-1883 (2021-03-24)
Objective: To identify differentially expressed genes via bioinformatical analysis for nasopharyngeal carcinoma (NPC) and explore potential biomarkers for NPC. Methods: We downloaded the NPC gene expression datasets (GSE40290, GSE53819) and obtained differentially expressed genes (DEGs) via GEO2R. Functional analysis of...
Ayse Ceren Calikoglu Koyuncu et al.
Biotechnology and bioengineering, 117(6), 1839-1852 (2020-02-19)
As cartilage is incapable of self-healing upon severe degeneration because of the lack of blood vessels, cartilage tissue engineering is gaining importance in the treatment of cartilage defects. This study was designed to improve cartilage tissue regeneration by expressing tissue...
Wataru Ariyoshi et al.
Biomedical research (Tokyo, Japan), 41(4), 187-197 (2020-08-18)
As chondrocytes fail to retain their chondrogenic potential in two-dimensional monolayer cultures, several three-dimensional culture systems have been employed for investigating the physiology and pathophysiology in articular cartilage tissues. In this study, we introduced a polyethylene glycol-coated microfabricated chip that...
Xiaoming Yang et al.
Cell & bioscience, 10, 103-103 (2020-09-19)
Long bones of limbs are formed through endochondral bone formation, which depends on the coordinated development of growth plates. Our previous studies have demonstrated that dysfunction of mitogen-activated protein kinase 7 (MAPK7) can cause skeletal dysplasia. However, little is known...
Ángela Fernández-Iglesias et al.
International journal of molecular sciences, 21(12) (2020-07-08)
Chronic kidney disease (CKD) alters the morphology and function of the growth plate (GP) of long bones by disturbing chondrocyte maturation. GP chondrocytes were analyzed in growth-retarded young rats with CKD induced by adenine intake (AD), control rats fed ad...
Michiko Yamashita et al.
Development (Cambridge, England), 145(1) (2017-11-29)
Transcriptional regulation can be tightly orchestrated by epigenetic regulators. Among these, ubiquitin-like with PHD and RING finger domains 1 (Uhrf1) is reported to have diverse epigenetic functions, including regulation of DNA methylation. However, the physiological functions of Uhrf1 in skeletal...
Sarah E Catheline et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 34(9), 1676-1689 (2019-06-13)
RUNX2 is a transcription factor critical for chondrocyte maturation and normal endochondral bone formation. It promotes the expression of factors catabolic to the cartilage extracellular matrix and is upregulated in human osteoarthritic cartilage and in murine articular cartilage following joint...
Lerdluck Ruengsinpinya et al.
Biochemical and biophysical research communications, 533(1), 90-96 (2020-09-16)
G protein signaling plays important roles in skeletal development. G protein subunit β1 (GNB1) is a component of the G protein complex and is associated with G protein signaling. In humans, GNB1 mutations cause global developmental and persistent growth delays...
Tingting Li et al.
Cell death & disease, 9(9), 849-849 (2018-08-30)
Molecular biomarkers that predict disease progression might promote drug development and therapeutic strategies in aggressive cancers, such as gastric cancer (GC). High-throughput mRNA sequencing (RNA-seq) revealed that collagen type X alpha 1 (COL10A1) is a disease progression-associated gene. Analysis of...
Seong Mi Choi et al.
Cell death & disease, 9(9), 866-866 (2018-08-31)
To investigate the functional effects of resveratrol (RSV) on mesenchymal stem cells (MSCs), we treated MSCs with RSV continuously during ex vivo expansion. MSCs were continuously treated with RSV from passage (P) 0 to P5. A proliferative capacity of RSV-treated...
Marta Giussani et al.
Journal of cellular physiology, 233(8), 6280-6290 (2018-03-10)
Changes in amount and composition of extracellular matrix (ECM) are considered a hallmark of tumor development. We tested the hypothesis that abnormal production of ECM components leads to blood-released ECM molecules representing tumor circulating biomarkers. Candidate genes were selected through...
Brandoch Cook et al.
Cell chemical biology, 26(7), 926-935 (2019-04-30)
Disorders of bone healing and remodeling are indications with an unmet need for effective pharmacological modulators. We used a high-throughput screen to identify activators of the bone marker alkaline phosphatase (ALP), and discovered 6,8-dimethyl-3-(4-phenyl-1H-imidazol-5-yl)quinolin-2(1H)-one (DIPQUO). DIPQUO markedly promotes osteoblast differentiation...