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Ana Artero-Castro et al.
Autophagy, 11(9), 1499-1519 (2015-07-16)
The human ribosomal P complex, which consists of the acidic ribosomal P proteins RPLP0, RPLP1, and RPLP2 (RPLP proteins), recruits translational factors, facilitating protein synthesis. Recently, we showed that overexpression of RPLP1 immortalizes primary cells and contributes to transformation. Moreover
Leilani Ireland Way et al.
Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001), 23(1), 23-28 (2013-01-16)
To determine the utility of performing urine Gram stain for detection of bacteriuria compared to routine urine sediment examination and bacterial aerobic urine culture. Prospective, observational study. University teaching hospital. Urine samples acquired via cystocentesis through convenience sampling from 103
Diego Benitez et al.
Journal of medicinal chemistry, 54(10), 3624-3636 (2011-04-22)
For a fourth approach of quinoxaline N,N'-dioxides as anti-trypanosomatid agents against T. cruzi and Leishmania, we found extremely active derivatives. The present study allows us to state the correct requirements for obtaining optimal in vitro anti-T. cruzi activity. Derivatives possessing
Ridha Limame et al.
PloS one, 7(10), e46536-e46536 (2012-10-25)
Cell viability and motility comprise ubiquitous mechanisms involved in a variety of (patho)biological processes including cancer. We report a technical comparative analysis of the novel impedance-based xCELLigence Real-Time Cell Analysis detection platform, with conventional label-based endpoint methods, hereby indicating performance
Nam-Hui Yim et al.
Oncology reports, 34(2), 1058-1064 (2015-06-11)
Betulin, a triterpene from the bark of various species of birch tree, has various biological effects, including antiviral, antifungal and anticancer activities. The aim of the present study was to elucidate the mechanisms underlying the apoptotic effect of betulin in
Shiuh-Wen Luoh et al.
Molecular carcinogenesis, 58(5), 699-707 (2019-01-04)
GRB7 gene encodes a multi-domain signal transduction molecule and is part of the core of the HER-2 amplicon. GRB7 is commonly co-amplified and overexpressed with HER-2 in human breast cancer. This study addresses the role of GRB7 in HER-2 positive
Giel Vandemoortele et al.
Bio-protocol, 7(7), e2211-e2211 (2017-04-05)
The programmable Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-associated nuclease 9 (Cas9) technology revolutionized genome editing by providing an efficient way to cut the genome at a desired location (Ledford, 2015). In mammalian cells, DNA lesions trigger the error-prone non-homologous
Mayank Verma et al.
Cell stem cell, 23(4), 530-543 (2018-10-06)
Skeletal muscle is a complex tissue containing tissue resident muscle stem cells (satellite cells) (MuSCs) important for postnatal muscle growth and regeneration. Quantitative analysis of the biological function of MuSCs and the molecular pathways responsible for a potential juxtavascular niche for
Roman Makarov et al.
Methods in molecular biology (Clifton, N.J.), 961, 201-218 (2013-01-18)
The characterization of the quality and quantity of cell death has gained substantial interest over the past decades. More recently necroptosis as a programmed form of necrosis has been identified as an important additional form of cell death with relevance
Eufrânio N da Silva Júnior et al.
Bioorganic & medicinal chemistry, 16(9), 5030-5038 (2008-04-02)
New naphthoquinone derivatives were synthesized and assayed against bloodstream trypomastigote forms of Trypanosoma cruzi, the etiological agent of Chagas' disease. The compounds were rationalized based on hybrid drugs and appear as important compounds against this parasite. From nor-lapachol were prepared
Troy D Bornes et al.
Bio-protocol, 5(24) (2016-05-24)
Bone marrow-derived mesenchymal stromal stem cells (BMSCs) are a promising cell source for treating articular cartilage defects (Bornes et al., 2014). BMSCs can be seeded within porous biomaterial scaffolds that support three-dimensional cell organization, chondrogenic differentiation and extracellular matrix deposition
Kaiyang Cai et al.
Forensic science international, 226(1-3), 240-243 (2013-02-23)
A new method based on the use of highly fluorescent water-soluble cadmium telluride (CdTe) quantum dots (QDs) capped with mercaptosuccinic acid (MSA) was explored to develop latent fingerprints. After optimized the effectiveness of QDs method contains pH value and developing
Wenduo Gu et al.
Arteriosclerosis, thrombosis, and vascular biology, 39(6), 1055-1071 (2019-04-05)
Objective- Vascular adventitia encompasses progenitors and is getting recognized as the major site of inflammation in early stage of atherosclerosis. However, the cellular atlas of the heterogeneous adventitial cells, the intercellular communication, the cellular response of adventitia to hyperlipidemia, and
Ke-Hung Chien et al.
Scientific reports, 8(1), 114-114 (2018-01-10)
Periodontal disease may cause considerable destruction of alveolar bone, periodontal ligaments (PDLs) and cementum and even lead to progressive oral dysfunction. Periodontal tissue regeneration is the ultimate goal of periodontal disease treatment to reconstruct both structures and functions. However, the
Lucie Hebert et al.
Oncotarget, 8(42), 72513-72527 (2017-10-27)
The tumor suppressor BAP1 associates with ASXL1/2 to form the core Polycomb complex PR-DUB, which catalyzes the removal of mono-ubiquitin from several substrates including histone H2A. This complex also mediates the poly-deubiquitination of HCFC1, OGT and PCG1-α, preventing them from
José Mauricio dos Santos Filho et al.
Bioorganic & medicinal chemistry, 17(18), 6682-6691 (2009-08-18)
Research in recent years has demonstrated that the Trypanosoma cruzi cysteine protease cruzain (TCC) is a valid chemotherapeutic target, since inhibitors of this protease affect the pathology appropriately. By exploring the N-acylhydrazones (NAH) as privileged structures usually present in antiparasitic
Lin-Ping Wu et al.
Nature communications, 10(1), 4635-4635 (2019-10-13)
The filamentous bacteriophage fd bind a cell target with exquisite specificity through its few copies of display peptides, whereas nanoparticles functionalized with hundreds to thousands of synthetically generated phage display peptides exhibit variable and often-weak target binding. We hypothesise that
Zhanqi Gao et al.
Journal of separation science, 36(6), 1112-1118 (2013-02-26)
A simple, environment friendly and efficient technique, ionic liquid-based microwave-assisted extraction was first used to determine malachite green and crystal violet (CV) from water samples coupled to HPLC. The key parameters influencing extraction efficiency were investigated, such as the type
Shin-Il Kim et al.
Nature communications, 9(1), 939-939 (2018-03-07)
Gene-edited induced pluripotent stem cells (iPSCs) provide relevant isogenic human disease models in patient-specific or healthy genetic backgrounds. Towards this end, gene targeting using antibiotic selection along with engineered point mutations remains a reliable method to enrich edited cells. Nevertheless, integrated
Gram stain for Vibrio species.
Chia-Chang Kuo et al.
The American journal of emergency medicine, 31(5), 877-878 (2013-03-19)
Songyuan Bao et al.
Molecular biology reports, 40(2), 1927-1936 (2012-10-19)
Two new laccase genes, named lac1 and lac2, were cloned from the edible basidiomycete Coprinus comatus. Comparison of the deduced amino acid sequences revealed two laccases showed 66.12 % identity and clustered with lac2 and lac3 from Coprinopsis cinerea in same
Chia-Hsun Fang et al.
Journal of biomedical science, 27(1), 42-42 (2020-03-15)
The underlying mechanism involved in ovarian cancer stemness and chemoresistance remains largely unknown. Here, we explored whether the regulation of c-Kit and plasma membrane prohibitin (PHB) affects ovarian cancer stemness and chemotherapy resistance. Mass spectrum analysis and an in vitro
Henry M Wu et al.
BMC infectious diseases, 13, 26-26 (2013-01-24)
Although cerebrospinal fluid (CSF) culture is the diagnostic reference standard for bacterial meningitis, its sensitivity is limited, particularly when antibiotics were previously administered. CSF Gram staining and real-time PCR are theoretically less affected by antibiotics; however, it is difficult to
Douglas V Faget et al.
PloS one, 7(10), e47868-e47868 (2012-10-31)
The proteins belonging to the nuclear factor of activated T cells (NFAT) family of transcription factors are expressed in several cell types and regulate genes involved in differentiation, cell cycle and apoptosis. NFAT proteins share two conserved domains, the NFAT-homology
Ziru Lian et al.
Journal of separation science, 36(5), 980-985 (2013-02-08)
A highly selective sample cleanup procedure combined with molecularly imprinted SPE was developed for the isolation of crystal violet from seawater and seafood samples. The molecularly imprinted polymer was prepared using crystal violet as the template molecule, methacrylic acid as
Hidemasa Nakaminami et al.
Antimicrobial agents and chemotherapy, 54(10), 4107-4111 (2010-07-28)
Plasmids that carry the multidrug efflux genes qacA and qacB are widely distributed in methicillin-resistant Staphylococcus aureus (MRSA). Although the QacA and QacB proteins are similar to each other, their respective substrate specificities may differ. We investigated the variability and
F Jahan et al.
The Malaysian journal of pathology, 36(3), 175-180 (2014-12-17)
Urethritis is one of the most important causes of morbidity and mortality in developing countries. The aim of this study was to detect common bacterial causes of urethritis in men by Gram stain, culture and multiplex PCR.185 male patients who
J X Zhang et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 67(4), 737-744 (2013-01-12)
The adsorption of crystal violet dye from aqueous solutions onto an activated carbon prepared from peanut shells was analyzed in this study. The effects of particle size, initial concentration, time and temperature on crystal violet removal were studied in batch
M Bartelsman et al.
Sexually transmitted infections, 90(5), 358-362 (2014-05-27)
To compare point-of-care (POC) systems in two different periods: (1) before 2010 when all high-risk patients were offered POC management for urogenital gonorrhoea by Gram stain examination; and (2) after 2010 when only those with symptoms were offered Gram stain
Hong-Xia Bi et al.
Chinese medical journal, 128(3), 373-377 (2015-01-31)
As a novel molecular markerof non-small cell lung cancer (NSCLC), PRDI-BF1 and RIZ homology domain containing protein 14 (PRDM14) is over-expressed in NSCLC tumor tissues. Extracellular matrix degradation mediated by the balance between matrix metalloproteinases (MMPs) and tissue inhibitor of
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