Showing 1-20 of 20 results for "


Dan Suan et al.
Immunity, 47(6), 1142-1153 (2017-12-21)
Memory B cells (MBCs) and plasma cells (PCs) constitute the two cellular outputs of germinal center (GC) responses that together facilitate long-term humoral immunity. Although expression of the transcription factor BLIMP-1 identifies cells undergoing PC differentiation, no such marker exists...
Hannah R Schlotterer et al.
Journal of pediatric gastroenterology and nutrition, 69(3), 370-374 (2019-05-21)
The aim of the study was to assess the total protein, lysozyme, and immunoglobulin A (IgA) content of unfortified and fortified Holder-pasteurized donor human milk (HPDHM) during 96 hours of refrigerated storage. HPDHM was prepared in a hospital feeding room...
A Irazusta et al.
Journal of dairy science, 103(7), 5978-5991 (2020-05-19)
Human milk (HM) constitutes the first immunological barrier and the main source of nutrients and bioactive components for newborns. Immune factors comprise up to 10% of the protein content in HM, where antibodies are the major components (mainly IgA, IgG...
A Aase et al.
Mucosal immunology, 9(4), 884-893 (2015-10-29)
Whole-saliva IgA appears like an attractive noninvasive readout for intestinal immune induction after enteric infection or vaccination, but has failed to show consistent correlation with established invasive markers and IgA in feces or intestinal lavage. For reference, we measured antibodies...
Further development of lactoferrin immunosensor (part III)
Campanella L, et al.
Journal of Pharmaceutical and Biomedical Analysis, 186-193 (2010)
Jan Holmgren et al.
Nature medicine, 11(4 Suppl), S45-S53 (2005-04-07)
There is currently great interest in developing mucosal vaccines against a variety of microbial pathogens. Mucosally induced tolerance also seems to be a promising form of immunomodulation for treating certain autoimmune diseases and allergies. Here we review the properties of...
Danielle E Baranova et al.
Pathogens & immunity, 5(1), 89-116 (2021-06-18)
In cholera epidemics, the spread of disease can easily outpace vaccine control measures. The advent of technologies enabling the expression of recombinant proteins, including antibodies, in the milk of transgenic animals raises the prospect of developing a self-administered and cost-effective...
D Tudor et al.
Mucosal immunology, 2(5), 412-426 (2009-07-10)
AIDS is mainly a sexually transmitted disease, and accordingly, mucosal tissues are the primary sites of natural human immunodeficiency virus type-1 (HIV-1) transmission. Mucosal immunoglobulin A (IgA) antibody specific for HIV-1 envelope gp41 subunit is one correlate of protection in...
M Raux et al.
Journal of immunological methods, 222(1-2), 111-124 (1999-02-18)
Enzyme-linked immunosorbent assays (ELISA) were developed to test, in serum and mucosal samples, total IgG, total IgA, serum albumin, and anti-gp120 MN and anti-p24 LAI IgG and IgA levels. These ELISAs were optimized according to reagents and experimental conditions. Inter-...
Katie L Edwards et al.
Conservation physiology, 7(1), coy077-coy077 (2019-03-25)
Additional measures of well-being would be beneficial to the management of a variety of species in human care, including elephants. Immunoglobulin A (IgA) is an immune protein associated with pathogen defense, which has been demonstrated to decrease during times of...
Beom Jin Lim et al.
Yonsei medical journal, 52(4), 610-615 (2011-05-31)
Deposition of polymeric IgA1 in the kidney mesangium is the hallmark of IgA nephropathy, but the molecular mechanisms of IgA-mediated mesangial responses and inflammatory injuries remain poorly understood. We hypothesize that Toll-like receptor 4 (TLR4) is involved in IgA-induced mesangial...
Shona L Halson et al.
Medicine and science in sports and exercise, 35(5), 854-861 (2003-05-17)
Acute bouts of prolonged strenuous exercise are often associated with immune suppression and an increased risk of infection. However, few studies have examined immunological responses to intensified training that results in overreaching or overtraining. We investigated the effects of intensified...
Valérie Lorin et al.
Journal of immunological methods, 422, 102-110 (2015-04-26)
Immunoglobulin A (IgA) is the most abundant antibody isotype produced in humans. IgA antibodies primarily ensure immune protection of mucosal surfaces against invading pathogens, but also circulate and are present in large quantities in blood. IgAs are heterogeneous at a...
Van Trung Chu et al.
Arthritis and rheumatism, 60(7), 2083-2093 (2009-07-01)
Elevated levels of BAFF and APRIL are characteristic of patients with systemic lupus erythematosus (SLE). The reasons for enhanced cytokine production are not well understood. This study was undertaken to identify the cells responsible for the overproduction of these cytokines....
Tithipong Plangsangmas et al.
Animals : an open access journal from MDPI, 10(1) (2020-01-23)
Salivary immunoglobulin A (sIgA) has been proposed as a potential indicator of welfare for various species, including Asian elephants, and may be related to adrenal cortisol responses. This study aimed to distinguish circadian rhythm effects on sIgA in male and...
Matthew Paul et al.
mAbs, 6(6), 1585-1597 (2014-12-09)
Recombinant Secretory IgA (SIgA) complexes have the potential to improve antibody-based passive immunotherapeutic approaches to combat many mucosal pathogens. In this report, we describe the expression, purification and characterization of a human SIgA format of the broadly neutralizing anti-HIV monoclonal...
A T Nagao et al.
Scandinavian journal of immunology, 53(6), 602-609 (2001-06-26)
A high prevalence of systemic infections caused by enterobacteria such as Escherichia coli is observed during the neonatal period. Lipopolysaccharide (LPS) is one of the major factors responsible for septic shock caused by these Gram-negative bacteria. We have recently demonstrated...
Maryanne T Perrin et al.
Maternal & child nutrition, 14 Suppl 6, e12566-e12566 (2018-12-29)
Expressed human milk can be donated or sold through a variety of channels, including human milk banks, corporations or individuals, or peer-to-peer milk sharing. There is a paucity of research regarding the nutrient and bioactive profiles of expressed human milk...