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Loyal A Goff et al.
Experimental hematology, 36(10), 1354-1369 (2008-07-29)
Human multipotent mesenchymal stromal cells (MSC) have the potential to differentiate into multiple cell types, although little is known about factors that control their fate. Differentiation-specific microRNAs may play a key role in stem cell self-renewal and differentiation. We propose
Ci-Xiang Zhou et al.
Oncotarget, 7(2), 1288-1299 (2015-11-26)
MicroRNAs have been integrated into tumorigenic programs as either oncogenes or tumor suppressor genes. The miR-630 was reported to be deregulated and involved in tumor progression of several human malignancies. However, its expression regulation shows diversity in different kinds of
M L Alves da Silva et al.
Journal of tissue engineering and regenerative medicine, 9(6), 714-723 (2013-10-25)
Paracrine signalling from chondrocytes has been reported to increase the synthesis and expression of cartilage extracellular matrix (ECM) by stem cells. The use of conditioned medium obtained from chondrocytes for stimulating stem cells chondrogenic differentiation may be a very interesting
Guihua Du et al.
Development (Cambridge, England), 147(8) (2020-03-20)
Continual spermatogenesis relies on the actions of an undifferentiated spermatogonial population that is composed of stem cells and progenitors. Here, using mouse models, we explored the role of RNA-binding proteins (RBPs) in regulation of the biological activities of this population.
Yosuke Watanabe et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(4), 5827-5837 (2020-03-07)
Reactive oxygen species (ROS) increase during adipogenesis and in obesity. Oxidants react with cysteine residues of proteins to form glutathione (GSH) adducts, S-glutathionylation, that are selectively removed by glutaredoxin-1 (Glrx). We have previously reported that Glrx knockout mice had increased
Mi Yang et al.
Theriogenology, 148, 68-75 (2020-03-08)
Spermatogonial stem cells (SSCs) are defined as the tissue-specific stem cells in the testes that produce sperm and support life-long spermatogenesis. A culture microenvironment could convert mouse SSCs from unipotent to pluripotent states; however, the underlying mechanism is unclear. NANOG
Haopeng Xiao et al.
Cell, 180(5), 968-983 (2020-02-29)
Mammalian tissues engage in specialized physiology that is regulated through reversible modification of protein cysteine residues by reactive oxygen species (ROS). ROS regulate a myriad of biological processes, but the protein targets of ROS modification that drive tissue-specific physiology in vivo
Elie Baho et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 39(23), 4489-4510 (2019-04-03)
By virtue of their extensive axonal arborization and perisomatic synaptic targeting, cortical inhibitory parvalbumin (PV) cells strongly regulate principal cell output and plasticity and modulate experience-dependent refinement of cortical circuits during development. An interesting aspect of PV cell connectivity is
LRRK2 Inhibition Ameliorates Dexamethasone-Induced Glucose Intolerance via Prevents Impairment in GLUT4 Membrane Translocation in Adipocytes.
Imai, et al.
Biological & Pharmaceutical Bulletin, 43, 1660-1668 (2020)
Abeer Dagra et al.
NPJ Parkinson's disease, 7(1), 76-76 (2021-08-20)
Pathophysiological damages and loss of function of dopamine neurons precede their demise and contribute to the early phases of Parkinson's disease. The presence of aberrant intracellular pathological inclusions of the protein α-synuclein within ventral midbrain dopaminergic neurons is one of
Lianchun Fan et al.
Stem cells and development, 17(3), 585-597 (2008-06-26)
Although embryonic germ (EG) cell-mediated gene transfer has been successful in the mouse for more than a decade, this approach is limited in other species due to the difficulty of isolating the small numbers of progenitors of germ cell lineage
Jiani Wang et al.
PloS one, 15(4), e0231796-e0231796 (2020-04-15)
Antimicrobial peptide expression is associated with disease activity in inflammatory bowel disease (IBD) patients. IBD patients have abnormal expression of elafin, a human elastase-specific protease inhibitor and antimicrobial peptide. We determined elafin expression in blood, intestine, and mesenteric fat of
Morad-Rémy Muhsin-Sharafaldine et al.
Biochimica et biophysica acta, 1861(2), 286-295 (2016-11-20)
Chemotherapy induces the release of apoptotic vesicles (ApoV) from the tumor plasma membrane. Tumor ApoV may enhance the risk of thrombotic events in cancer patients undergoing chemotherapy. However, the relative contribution of ApoV to coagulation and the pathways involved remain
A J C Dennison et al.
Soft matter, 12(3), 824-829 (2015-11-06)
The carefully controlled permeability of cellular membranes to biological molecules is key to life. In degenerative diseases associated with protein misfolding and aggregation, protein molecules or their aggregates are believed to permeate these barriers and threaten membrane integrity. We used
Alessandro Carrer et al.
Cancer discovery, 9(3), 416-435 (2019-01-11)
Pancreatic ductal adenocarcinoma (PDA) has a poor prognosis, and new strategies for prevention and treatment are urgently needed. We previously reported that histone H4 acetylation is elevated in pancreatic acinar cells harboring Kras mutations prior to the appearance of premalignant
Natalie A Dye et al.
Development (Cambridge, England), 144(23), 4406-4421 (2017-10-19)
Quantitative analysis of the dynamic cellular mechanisms shaping the
Xudong Sun et al.
Journal of dairy science, 102(6), 5673-5685 (2019-04-08)
Dairy cows with ketosis display excessive lipolysis in adipose tissue. Heat-shock protein B7 (HSPB7), a small heat-shock protein, plays important roles in mediating cytoprotective responses to oxidative stress in rodent adipose tissue. Accordingly, it is assumed that HSPB7 may also
Jianqing Liang et al.
Cell death and differentiation, 28(2), 799-813 (2020-10-29)
Entosis was proposed to promote aneuploidy and genome instability by cell-in-cell mediated engulfment in tumor cells. We reported here, in epithelial cells, that entosis coupled with mitotic arrest functions to counteract genome instability by targeting aneuploid mitotic progenies for engulfment
Maik Dahlhoff et al.
The Journal of investigative dermatology, 137(4), 921-930 (2016-12-10)
Although the epidermal growth factor receptor has established roles in skin carcinogenesis, inflammation, and wound healing, the functions of the structurally related receptor ERBB2 in this tissue remain poorly explored. To assess the functions of ERBB2 in skin homeostasis, tumorigenesis
Mohamed R Ben Khedher et al.
PeerJ, 6, e4166-e4166 (2018-01-16)
Diet-induced obese (DIO) mice were treated for five weeks with sage methanol extract (100 and 400 mg kg After two weeks of treatment, the lower dose of sage MetOH extract decreased blood glucose and plasma insulin levels during an oral glucose
Keiko Danzaki et al.
European journal of immunology, 46(11), 2669-2678 (2016-11-05)
Osteopontin (OPN) is a protein, generally considered to play a pro-tumorigenic role, whereas several reports have demonstrated the anti-tumorigenic function of OPN during tumor development. These opposing anti- and pro-tumorigenic functions are not fully understood. Here, we report that host-derived
Yusuke Ogihara et al.
Scientific reports, 7, 40047-40047 (2017-01-07)
The facile synthesis of ZnS-AgInS
Manami Kodaka et al.
PloS one, 15(4), e0231265-e0231265 (2020-04-09)
Transcriptional co-activator with PDZ-binding motif (TAZ) plays versatile roles in the regulation of cell proliferation and differentiation. TAZ activity changes in response to the cellular environment such as mechanic and nutritional stimuli, osmolarity, and hypoxia. To understand the physiological roles
Dan Huang et al.
Molecular cell, 79(6), 934-949 (2020-08-22)
Although ADP-ribosylation of histones by PARP-1 has been linked to genotoxic stress responses, its role in physiological processes and gene expression has remained elusive. We found that NAD+-dependent ADP-ribosylation of histone H2B-Glu35 by small nucleolar RNA (snoRNA)-activated PARP-1 inhibits AMP
Dharsan K Soundarrajan et al.
PLoS computational biology, 17(11), e1009543-e1009543 (2021-11-02)
Information flow within and between cells depends significantly on calcium (Ca2+) signaling dynamics. However, the biophysical mechanisms that govern emergent patterns of Ca2+ signaling dynamics at the organ level remain elusive. Recent experimental studies in developing Drosophila wing imaginal discs
Payam Vahmani et al.
Lipids, 51(11), 1231-1239 (2016-10-25)
During ruminal biohydrogenation of α-linolenic acid, a non-conjugated non-methylene interrupted dienoic acid is formed containing a t10 double bond, namely t10,c15-18:2. The present study was designed to examine whether t10,c15-18:2 would exert similar anti-adipogenic effects compared to t10,c12-18:2 in 3T3-L1
Aidan B Grosas et al.
Journal of molecular biology, 432(20), 5593-5613 (2020-08-23)
One of the most crowded biological environments is the eye lens which contains a high concentration of crystallin proteins. The molecular chaperones αB-crystallin (αBc) with its lens partner αA-crystallin (αAc) prevent deleterious crystallin aggregation and cataract formation. However, some forms
Cara A Timpani et al.
Antioxidants (Basel, Switzerland), 9(12) (2020-12-17)
The discordance between pre-clinical success and clinical failure of treatment options for Duchenne Muscular Dystrophy (DMD) is significant. The termination of clinical trials investigating the phosphodiesterase inhibitors, sildenafil and tadalafil (which prolong the second messenger molecule of nitric oxide (NO)
Ling Ren et al.
Genes, 11(6) (2020-06-04)
Intramuscular fat (IMF) is one of the major factors determining beef quality. IMF formation is influenced by multiple conditions including genetic background, age and nutrition. In our previous investigation, bta-miR-210 was found to be increased during adipogenesis using miRNA-seq. In
Yurui Duan et al.
The Journal of biological chemistry, 295(37), 12868-12884 (2020-06-26)
Diabetic nephropathy (DN) is a complication of diabetes that is increasing in prevalence in China. Extracellular vesicles (EVs) carrying microRNAs (miRs) may represent a useful tool in the development of therapies for DN. Here, we report that EVs released by
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