Showing 1-30 of 66 results for "I7000000"
A M Tortorano et al.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 33(9), 1623-1630 (2014-05-06)
In order to better understand the epidemiology of fusariosis in Europe, a survey collecting information on the clinical characteristics of the patients infected by Fusarium as well as on the infecting isolates was launched. A total of 76 cases of...
Jadwiga Stachowicz et al.
Indian journal of pharmaceutical sciences, 76(4), 287-298 (2014-10-07)
Due to the increasing demand for new pharmaceuticals showing biological activity against pathogenic microorganisms, there is increasing search for new compounds with predicted biological activity. Variously substituted thioamide derivatives with 1.3 and 1.2 ring of thiazole and 1,3,4-thiadiazole, as well...
Marie Charles et al.
Therapie, 66(2), 103-108 (2011-06-04)
Itraconazole is a triazole antifungal agent that is active against Aspergillus, histoplasmosis, and rare fungal infections. Itraconazole exhibit marked variability in drug concentration as a result of inconsistent absorption, metabolism, or interaction with concomitant medications. Preclinical and clinical data have...
Hans Christian Korting et al.
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 7(1), 11-19 (2008-05-16)
Itraconazole is an antifungal drug from the triazole group with distinct in vitro activity against dermatophytes, yeasts and some molds. Itraconazole has a primarily fungistatic activity. Itraconazole accumulates in the stratum corneum and in nail material due to its high...
Shradha Subedi et al.
The American journal of tropical medicine and hygiene, 91(6), 1263-1268 (2014-09-10)
We report three cases of lymphocutaneous infection caused by the thermally dimorphic fungus, Sporothrix schenckii from Australia's tropical Northern Territory. Two cases were acquired locally, making them the first to be reported from this region. All three cases presented with...
Hiroshi Tsubamoto et al.
Anticancer research, 34(4), 2007-2014 (2014-04-03)
Recurrent ovarian clear cell carcinoma (CCC) rarely responds to cytotoxic agents. Itraconazole is a potent inhibitor of the P-glycoprotein efflux pump, angiogenesis, and the Hedgehog pathway. We evaluated the efficacy of chemotherapy with itraconazole for CCC. Medical charts of patients...
Hiroshi Tsubamoto et al.
Anticancer research, 34(7), 3839-3844 (2014-07-02)
Recurrent triple-negative breast cancer (TNBC) patients have poor prognoses and limited treatment options, especially after progression during prior chemotherapy. The present study aimed to determine the impact of itraconazole with chemotherapy in these patients. Medical records of recurrent TNBC patients...
Susan S Buchkowsky et al.
Therapeutic drug monitoring, 27(3), 322-333 (2005-05-21)
Itraconazole is a synthetic triazole antifungal agent that is commonly used in the prophylaxis and treatment of fungal infection. A role for itraconazole drug monitoring has been suggested previously; however, the advent of new formulations and increased clinical evidence may...
J W van 't Wout et al.
Nederlands tijdschrift voor geneeskunde, 148(34), 1679-1684 (2004-09-30)
The azole antifungal voriconazole and the echinocandin caspofungin have recently become available for the treatment of invasive mycoses. Fluconazole remains the drug of choice for candidemia, except for infections with one of the resistent species such as Candida krusei and...
Nikhil N Kulkarni et al.
Molecular immunology, 63(2), 530-539 (2014-12-03)
Antimicrobial peptides (AMPs) constitute an indispensable arm of innate immunity against infectious microbes in humans. Induction of endogenous AMPs may become an alternative therapy against infections. Our previous studies have demonstrated phenylbutyrate (PBA) as a novel inducer of the AMPs...
Maria Helena G Figueiredo-Carvalho et al.
Mycopathologia, 178(1-2), 27-35 (2014-06-24)
Two commercial methods, the Etest and Vitek 2, were compared with the Clinical and Laboratory Standards Institute broth microdilution method to determine the susceptibility of Candida parapsilosis complex to amphotericin B, caspofungin, fluconazole, voriconazole, and itraconazole. One-hundred bloodstream isolates of...
Lanlan Jiang et al.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 43(9), 696-703 (2014-06-17)
Highly active antiretroviral therapy (HAART) as an effective therapy for immune reconstruction among patients with HIV/AIDS might have influence on oral Candida status. We investigated oral Candida carriage, distribution, and antifungal susceptibility dynamically during the first year of HAART among...
Naila A Mugheirbi et al.
International journal of pharmaceutics, 471(1-2), 400-411 (2014-06-01)
Itraconazole (ITR) is an antifungal drug with a limited bioavailability due to its poor aqueous solubility. In this study, ITR was used to investigate the impact of nanonisation and solid state change on drug's apparent solubility and dissolution. A bottom...
V Mistretta et al.
Acta clinica Belgica, 69(1), 53-61 (2014-03-19)
Azole antifungals are a group of fungistatic agents that can be administered orally or parenterally. The determination of the concentrations of these antifungals (miconazole, fluconazole, ketoconazole, posaconazole, voriconazole, itraconazole, and its major active metabolite, hydroxy-itraconazole) in serum can be useful...
E Kaminska et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(3), 1094-1104 (2014-12-03)
Different experimental and theoretical techniques were applied to investigate basic physical properties of very stable and homogeneous solid dispersions formed by itraconazole and octaacetylmaltose. Differential scanning calorimetry as well as semi-empirical calculations have indicated that liquid crystalline ordering in itraconazole...
Vincenzo Savini et al.
Mycopathologia, 166(1), 47-50 (2008-04-30)
Genitourinary infections caused by non-Candida yeasts are uncommon, and especially due to Saccharomyces cerevisiae. We describe the cases of two adult females with vulvovaginal infections caused by itraconazole-resistant S. cerevisiae who made a full recovery after oral fluconazole therapy. We...
André Ferraz Goiana Leal et al.
Mycopathologia, 179(3-4), 225-229 (2014-11-29)
The aim of this study was to assess the efficacy of topical application of a liposomal formulation of itraconazole for the treatment of experimental keratitis with endophthalmitis caused by Aspergillus flavus. The liposomes were obtained by the lipid film hydration...
A O S Fonseca et al.
The Journal of antimicrobial chemotherapy, 69(6), 1564-1567 (2014-02-14)
The purpose of this study was to compare the in vitro susceptibilities of 22 Brazilian isolates of Pythium insidiosum to antifungals using a standardized inoculum of zoospores and a proposed novel inoculum prepared from cultured mycelia (hyphae) of P. insidiosum....
Ya-li Yang et al.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 26, 154-161 (2014-07-27)
Cryptococcosis is a severe fungal infection with a high mortality rate among solid-organ transplant recipients. Today, China is among the countries performing the most kidney transplants worldwide, however data on the association of cryptococcosis with kidney transplantation in mainland China...
Michael Potter
The Journal of antimicrobial chemotherapy, 56 Suppl 1, i49-i54 (2005-08-27)
Systemic fungal infections are an increasing cause of mortality and morbidity in patients with haematological malignancies and certain other conditions associated with profound immunosuppression. The majority of such infections are caused by Aspergillus and Candida species. In recent years, the...
Recurrent tinea versicolor: treatment with itraconazole or fluconazole?
Anastasia Pantazidou et al.
Archives of disease in childhood, 92(11), 1040-1042 (2007-10-24)
Ruihua Wang et al.
Obstetrics and gynecology, 124(2 Pt 2 Suppl 1), 423-425 (2014-07-09)
Majocchi granuloma is a cutaneous dermatophyte infection of the dermal and subcutaneous tissues characterized by chronic erythematous and indurated plaques, which are almost always the result of immunodeficiency and trauma. Disseminated dermatophyte Majocchi granuloma was diagnosed in a 19-year-old woman...
Shi-Hai Xie et al.
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 28(3), 442-444 (2006-08-12)
Itraconazole has been used to treat superficial candidal infections in China for 12 years with promising efficacy and safety. This article retrospectively reviewed literatures published in the mainstream journals in China with an attempt to find a reasonable therapy for...
Mar Bermúdez et al.
Journal of pediatric hematology/oncology, 27(7), 389-392 (2005-07-14)
Itraconazole is particularly attractive in fungal prophylaxis for cancer patients due to its broad spectrum, including Candida and Aspergillus. It is generally well tolerated. However, its efficacy in preventing invasive aspergillosis could not be demonstrated. A 3-year-old boy diagnosed with...
Yongxuan Hu et al.
Mycopathologia, 179(1-2), 103-109 (2014-11-05)
Chromoblastomycosis, a chronic fungal infection of skin and subcutaneous tissue caused by dematiaceous fungi, is associated with low cure and high relapse rates. Among all factors affecting clinical outcome, etiological agents have an important position. In southern China, Fonsecaea pedrosoi...
Ildikó Nyilasi et al.
Medical mycology, 52(2), 140-148 (2013-09-06)
The investigation of the antifungal activities of drugs whose primary activities are not related to their antimicrobial potential is in the current forefront of research. Statin compounds, which are routinely used as cholesterol-lowering drugs, may also exert direct antimicrobial effects....
Samuel O Kyeremateng et al.
Journal of pharmaceutical sciences, 103(9), 2847-2858 (2014-03-19)
A novel empirical analytical approach for estimating solubility of crystalline drugs in polymers has been developed. The approach utilizes a combination of differential scanning calorimetry measurements and a reliable mathematical algorithm to construct complete solubility curve of a drug in...
Zsombor K Nagy et al.
International journal of pharmaceutics, 480(1-2), 137-142 (2015-01-18)
High speed electrospinning (HSES), compatible with pharmaceutical industry, was used to demonstrate the viability of the preparation of drug-loaded polymer nanofibers with radically higher productivity than the known single-needle electrospinning (SNES) setup. Poorly water-soluble itraconazole (ITRA) was formulated with PVPVA64...
J William Higgins et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(11), 1780-1784 (2014-08-12)
Ketoconazole is no longer available for clinical determination of worst-case victim drug-drug interaction (DDI) potential for cytochrome P450 3A (CYP3A)-substrate drugs; clarithromycin and itraconazole are the proposed replacements. Ketoconazole DDIs are described by unbound systemic exposures due to absence of...
R Caputo
Expert review of anti-infective therapy, 1(4), 531-542 (2004-10-16)
Itraconazole (Sporanox) is a triazole antifungal agent with a broad activity spectrum and favorable pharmacokinetic and safety profiles. Numerous clinical trials have established the efficacy and safety of itraconazole in the treatment of superficial fungal infections. In this field, full...

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