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Showing 1-30 of 680 results for "I7018" within Papers
Haopeng Xiao et al.
Cell, 180(5), 968-983 (2020-02-29)
Mammalian tissues engage in specialized physiology that is regulated through reversible modification of protein cysteine residues by reactive oxygen species (ROS). ROS regulate a myriad of biological processes, but the protein targets of ROS modification that drive tissue-specific physiology in vivo
David Pretzel et al.
Arthritis research & therapy, 13(2), R64-R64 (2011-04-19)
Mesenchymal stem cells (MSC) are highly attractive for use in cartilage regeneration. To date, MSC are usually recruited from subchondral bone marrow using microfracture. Recent data suggest that isolated cells from adult human articular cartilage, which express the combination of
Qianglin Liu et al.
Cell reports, 42(3), 112166-112166 (2023-03-02)
Distinct locations of different white adipose depots suggest anatomy-specific developmental regulation, a relatively understudied concept. Here, we report a population of Tcf21 lineage cells (Tcf21 LCs) present exclusively in visceral adipose tissue (VAT) that dynamically contributes to VAT development and
Cheng-Long Wang et al.
Journal of cellular biochemistry, 118(2), 286-297 (2016-06-24)
Osteoblasts are essential for maintaining skeletal architecture and modulating bone microenvironment homeostasis. From numerous associated investigations, the BMP-2 pathway has been well-defined as a vital positive modulator of bone homeostasis. Gremlin2 (Grem2) is a bone morphogenetic protein (BMP) antagonists. However
Jiaojiao Wang et al.
Stem cell research & therapy, 6, 98-98 (2015-05-23)
Fallopian tube, which is normally discarded in surgical procedures, has proven to be a source of mesenchymal stem cells (MSCs) with increasing evidence. However, fallopian tube mucosa, which can be acquired via non-invasive procedures, is a previously unknown source of
Yulia Lazra et al.
Journal of cellular biochemistry, 116(5), 754-766 (2014-12-11)
Adiponectin is an adipose-derived hormone, with beneficial effects on insulin sensitivity and inflammation. The aim of this study was to clarify the autocrine/paracrine effects of globular adiponectin (gAd) administrated during differentiation on the function of the mature adipocytes. Experiments were
Zhipin Zhang et al.
Journal of cellular biochemistry (2019-11-07)
Brown adipocytes are rich in mitochondria and linked to the body's blood fat levels and obesity. MiR-92a is negatively correlated with the activity of brown adipocytes. This study aimed to explore the mechanism of miR-92a on brown adipocytes. The expression
Yan Fang et al.
Nucleic acids research, 52(9), 4950-4968 (2024-03-13)
Alterations in the tumor suppressor ATRX are recurrently observed in mesenchymal neoplasms. ATRX has multiple epigenetic functions including heterochromatin formation and maintenance and regulation of transcription through modulation of chromatin accessibility. Here, we show in murine mesenchymal progenitor cells (MPCs)
Nataša Obermajer et al.
Journal of immunology (Baltimore, Md. : 1950), 193(10), 4988-4999 (2014-10-12)
The ultimate goal in transplantation medicine is the promotion of operational tolerance. Although Th cells of the Th17 type have been predominantly associated with rejection of allogeneic solid organ grafts, regulatory T (T(reg)) cells appear to foster operational tolerance. Induced
Simona Cataldi et al.
Cells, 11(1) (2022-01-12)
Low-grade chronic inflammation and reduced differentiation capacity are hallmarks of hypertrophic adipose tissue (AT) and key contributors of insulin resistance. We identified PPARGΔ5 as a dominant-negative splicing isoform overexpressed in the AT of obese/diabetic patients able to impair adipocyte differentiation
Meizhu Bai et al.
PLoS biology, 17(7), e3000350-e3000350 (2019-07-03)
Mutagenic screening is powerful for identifying key genes involved in developmental processes. However, such screens are successful only in lower organisms. Here, we develop a targeted genetic screening approach in mice through combining androgenetic haploid embryonic stem cells (AG-haESCs) and
Chandrima Sinha et al.
Cellular signalling, 27(7), 1345-1355 (2015-04-07)
Multidrug resistance protein 4 (MRP4), a member of the ATP binding cassette transporter family, functions as a plasma membrane exporter of cyclic nucleotides. Recently, we demonstrated that fibroblasts lacking the Mrp4 gene migrate faster and contain higher cyclic-nucleotide levels. Here
Klaus Eyer et al.
Scientific reports, 5, 16551-16551 (2015-11-21)
The unwanted emergence of neutralizing antibodies (nAbs) against an endogenous or a therapeutic protein can result in deficiency diseases or therapy failure. Here, we developed a cell-free microfluidic method for the sensitive detection and quantification of nAbs in human serum
Hyo-Geun Lee et al.
Marine drugs, 19(2) (2021-02-12)
Sargassum horneri (S. horneri) is a well-known brown seaweed widely distributed worldwide. Several biological activities of S. horneri have been reported. However, its effects on lipid metabolism and the underlying mechanisms remain elusive. In the present study, we examined the
Sabrina Krautbauer et al.
Molecular and cellular biochemistry, 393(1-2), 69-76 (2014-04-18)
Adipogenesis is associated with the upregulation of the antioxidative enzyme manganese superoxide dismutase (MnSOD) suggesting a vital function of this enzyme in adipocyte maturation. In the current work, MnSOD was knocked-down with small-interference RNA in preadipocytes to study its role
B E J Spurgeon et al.
Journal of thrombosis and haemostasis : JTH, 12(10), 1733-1743 (2014-07-25)
Dissecting the signaling events that contribute to platelet activation will increase our understanding of platelet function and aid in the development of new antiplatelet agents. However, high-throughput methodology for the quantitative analysis of platelet signaling events is still lacking. To
Gerrit Erdmann et al.
Genome medicine, 7(1), 46-46 (2015-06-30)
Mesenchymal stem cells (MSCs) are promising candidates for cellular therapies ranging from tissue repair in regenerative medicine to immunomodulation in graft versus host disease after allogeneic transplantation or in autoimmune diseases. Nonetheless, progress has been hampered by their enormous phenotypic
Seira Narishige et al.
British journal of pharmacology, 171(24), 5858-5869 (2014-08-28)
Caffeine is one of the most commonly used psychoactive substances. Circadian rhythms consist of the main suprachiasmatic nucleus (SCN) clocks and peripheral clocks. Although caffeine lengthens circadian rhythms and modifies phase changes in SCN-operated rhythms, the effects on caffeine on
Cvetan Popov et al.
BMC molecular biology, 16, 6-6 (2015-04-17)
Tendons are dense connective tissues subjected periodically to mechanical stress upon which complex responsive mechanisms are activated. These mechanisms affect not only the development of these tissues but also their healing. Despite of the acknowledged importance of the mechanical stress
Yurui Duan et al.
The Journal of biological chemistry, 295(37), 12868-12884 (2020-06-26)
Diabetic nephropathy (DN) is a complication of diabetes that is increasing in prevalence in China. Extracellular vesicles (EVs) carrying microRNAs (miRs) may represent a useful tool in the development of therapies for DN. Here, we report that EVs released by
Ji-Kan Ryu et al.
The journal of sexual medicine, 11(2), 411-423 (2013-11-21)
Recently, much attention has focused on stem cell therapy; bone marrow-derived stem cells (BMSCs) are one of the most studied mesenchymal stem cells used in the field of erectile dysfunction (ED). However, a major limitation for the clinical application of
Yagiz Anasiz et al.
Current protocols, 4(4), e1032-e1032 (2024-04-12)
The therapeutic potential of mesenchymal stromal cells (MSCs) has been extensively investigated in both preclinical and clinical settings. Recent years have witnessed the emergence of numerous isolation protocols and culture techniques, ranging from the selection of subpopulations to preserve stemness
S Matsumura et al.
Oral diseases, 21(3), 361-372 (2014-09-03)
The characteristics of cell populations extracted from oral mucosal non-epithelial tissues and their ability to differentiate were evaluated in vitro as a potential source of cells for mandibular and corneal regeneration. Oral mucosal non-epithelial cells (OMNECs) were extracted from tissue
Brigitte E Blackman et al.
The Journal of biological chemistry, 286(14), 12590-12601 (2011-02-04)
Signaling through cAMP regulates most cellular functions. The spatiotemporal control of cAMP is, therefore, crucial for differential regulation of specific cellular targets. Here we investigated the consequences of PDE4B or PDE4D gene ablation on cAMP signaling at a subcellular level
Hossein Rahavi et al.
Journal of diabetes research, 2015, 878535-878535 (2015-04-22)
Regenerative and immunomodulatory properties of mesenchymal stem cells (MSCs) might be applied for type 1 diabetes mellitus (T1DM) treatment. Thus, we proposed in vitro assessment of adipose tissue-derived MSCs (AT-MSCs) immunomodulation on autoimmune response along with beta cell protection in
Chunbo Lin et al.
In vitro cellular & developmental biology. Animal, 51(10), 1102-1108 (2015-07-24)
Mesenchymal stem cells were first isolated and grown in vitro by Friedenstein over 40 yr ago; however, their isolation remains challenging as they lack unique markers for identification and are present in very small quantities in mesenchymal tissues and bone marrow.
Ondrej Cerny et al.
Journal of immunology (Baltimore, Md. : 1950), 194(10), 4901-4913 (2015-04-17)
The adenylate cyclase toxin-hemolysin (CyaA) plays a key role in the virulence of Bordetella pertussis. CyaA penetrates complement receptor 3-expressing phagocytes and catalyzes uncontrolled conversion of cytosolic ATP to the key second messenger molecule cAMP. This paralyzes the capacity of
Anna Maria Wróbel et al.
Toxicology letters, 238(2), 110-116 (2015-08-09)
In the present study, we examined cAMP levels and activation of the MAPK/ERK1/2 and PI3K/Akt signaling pathways in response to the actions of parabens on GPR30 in MCF-7 and MCF-10A cells. Cells were exposed to methyl-, propyl- or butylparaben at
Angelique Riepsamen et al.
PloS one, 10(5), e0126194-e0126194 (2015-05-06)
Following exit from meiosis I, mammalian oocytes immediately enter meiosis II without an intervening interphase, accompanied by rapid reassembly of a bipolar spindle that maintains condensed chromosomes in a metaphase configuration (metaphase II arrest). Here we study the effect of
Tanya M Laidlaw et al.
The Journal of allergy and clinical immunology, 133(6), 1692-1701 (2014-02-04)
Aspirin-exacerbated respiratory disease (AERD) is an inflammatory condition of the respiratory tract and is characterized by overproduction of leukotrienes (LT) and large numbers of circulating granulocyte-platelet complexes. LT production can be suppressed by prostaglandin E(2) (PGE(2)) and the cyclic AMP-dependent
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