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i8377

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The International Normalized Ratio calibrated for rivaroxaban has the potential to normalize prothrombin time results for rivaroxaban-treated patients: results of an in vitro study.
A Tripodi et al.
Journal of thrombosis and haemostasis : JTH, 9(1), 226-228 (2010-10-15)
Xiao-mei Xie et al.
Journal of environmental sciences (China), 16(2), 252-255 (2004-05-13)
The impact of triazophos, bensulfuron-methyl, chlobenthiazone on soil biochemical characteristics in a paddy soil under controlled moisture (flooded soil) and temperature (25 degrees C) condition was studied. The electron transport system (ETS)/dehydrogenase activity displayed a negative correlation with triazophos, bensulfuron-methyl
Sergio Ravasio et al.
Biochemistry, 41(25), 8120-8133 (2002-06-19)
The properties of the recombinant ferredoxin-dependent glutamate synthase of Synechocystis PCC6803 were determined by means of kinetic and spectroscopic approaches in comparison to those exhibited by the bacterial NADPH-dependent enzyme form. The ferredoxin-dependent enzyme was found to be similar to
Jang Hoon Kim et al.
Bioorganic & medicinal chemistry, 22(21), 6047-6052 (2014-10-04)
Clostridium perfringens is a Gram-positive spore-forming bacterium that causes food poisoning. The neuraminidase (NA) protein of C. perfringens plays a pivotal role in bacterial proliferation and is considered a novel antibacterial drug target. Based on screens for novel NA inhibitors
Iawen Hsu et al.
Oncotarget, 5(17), 7917-7935 (2014-10-04)
Clinical reports show males have a higher bladder cancer (BCa) incidence than females. The sexual difference of BCa occurrence suggests that estrogen and its receptors may affect BCa development. Estrogen receptor alpha (ERα) is the classic receptor to convey estrogen
Yang Hongwei et al.
Ecotoxicology and environmental safety, 59(2), 249-255 (2004-08-26)
Anaerobic biodegradability of organic compounds can be assessed from the changes in organic compounds, the end products, and the activity of microorganisms. In this study, all three of these variables were considered to integrate assessment of the anaerobic biodegradability of
Cheng Luo et al.
Journal of biochemical and biophysical methods, 68(2), 101-111 (2006-06-03)
A sensitive spectrophotometric assay for determining mitochondrial malate dehydrogenase activity is described. The assay measures NADH production by coupling it to the reduction of 2-(p-iodophenyl)-3(p-nitrophenyl)-5-phenyl tetrazolium chloride (INT). Via an intermediate electron carrier, either phenazine methosulfate or lipoamide dehydrogenase, INT
Jiahui Zhou et al.
Experimental biology and medicine (Maywood, N.J.), 240(7), 867-875 (2015-01-13)
This study investigated the role of miR-143 in the chemoresistance of osteosarcoma tumor cells and the associated mechanisms. Real-time PCR was used to measure miR-143 levels. Western blot was used to detect protein expression. Cell proliferation was analyzed by MTT
Zhen Ning Wee et al.
Nature communications, 6, 8746-8746 (2015-10-28)
Metastatic tumour recurrence due to failed treatments remains a major challenge of breast cancer clinical management. Here we report that interleukin-1 receptor-associated kinase 1 (IRAK1) is overexpressed in a subset of breast cancers, in particular triple-negative breast cancer (TNBC), where
Pui-Mun Wong et al.
Nature communications, 6, 8048-8048 (2015-08-28)
Autophagy is a cellular catabolic process critical for cell viability and homoeostasis. Inhibition of mammalian target of rapamycin (mTOR) complex-1 (mTORC1) activates autophagy. A puzzling observation is that amino acid starvation triggers more rapid autophagy than pharmacological inhibition of mTORC1
Constitutive activation of pp125fak in newly isolated human breast cancer cell lines.
Ignatoski KMW and Ethier SP
Breast Cancer Research and Treatment, 54, 173-173 (1999)
Jun Yin et al.
Huan jing ke xue= Huanjing kexue, 26(1), 56-62 (2005-04-30)
The effects of Cu2+, Zn2+, Cd2+, Hg2+, Ni2+, Pb2+ and Ag+ on TTC and INT-electron transport system activity are studied and the sensitivities of TTC and INT-electron transport system activity to seven tested heavy metals are compared to evaluate both
Hsiu-Hua Wang et al.
Archives of toxicology, 88(8), 1549-1559 (2014-02-27)
We previously reported that the sustained exposure of human urothelial cells (HUCs) to low-dose sodium arsenite induces changes in the gene expression profile and neoplastic transformation. In this study, we used the HumanMethylation27 BeadChip to analyze genome-wide methylation profiles and
J Yin et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 52(8), 231-239 (2005-11-30)
TTC and INT-electron transport system activity tests were compared for assessing heavy metal inhibition of activated sludge. The median inhibitory concentrations (IC50s) of Cu2+, Zn2+, Cd2+, Hg2+, Ni2+, Pb2+ and Ag+ measured via TTC test were lower than those measured
Xing Jun Li et al.
Journal of leukocyte biology, 81(1), 238-249 (2006-10-25)
The role of Leu505 of Nox2 on the NADPH oxidase activation process was investigated. An X-CGD PLB-985 cell line expressing the Leu505Arg Nox2 mutant was obtained, exactly mimicking the phenotype of a previously published X91+-CGD case. In a reconstituted cell-free
G A McFeters et al.
Symposium series (Society for Applied Microbiology), 85(28), 193S-200S (2001-09-07)
Conventional methods for detecting indicator and pathogenic bacteria in water may underestimate the actual population due to sublethal environmental injury, inability of the target bacteria to take up nutrients and other physiological factors which reduce bacterial culturability. Rapid and direct
Alexandra Poinas et al.
European journal of biochemistry, 269(4), 1243-1252 (2002-02-22)
In the O2- generating flavocytochrome b, the membrane-bound component of the neutrophil NADPH oxidase, electrons are transported from NADPH to O2 in the following sequence: NADPH --> FAD --> heme b -->O2. Although p-iodonitrotetrazolium (INT) has frequently been used as
Ewa Liwarska-Bizukojc et al.
Journal of biotechnology, 101(2), 165-172 (2003-02-06)
2-(p-Iodophenyl)-3-(p-nitrophenyl)-5-phenyltetrazolium chloride (INT) dehydrogenase test and RNA assay were introduced to evaluate biomass in the processes of aerobic biodegradation of the organic fraction of municipal solid waste (MSW) in bioreactors. It was found that RNA quantification by KOH/UV method delivered
Nigel G Ternan et al.
Biochemical and biophysical research communications, 290(2), 802-805 (2002-01-12)
The thermotolerant yeast Kluyveromyces marxianus IMB3 was capable of utilising either iminodiacetate or nitrilotriacetate as a sole source of nitrogen for growth. Cell extracts contained iminodiacetate dehydrogenase and nitrilotriacetate monooxygenase activities, suggesting the presence in the yeast of orthologues of
E E Tafel'shteĭn et al.
Zhurnal mikrobiologii, epidemiologii, i immunobiologii, (1)(1), 13-18 (2004-03-18)
In experiments with the cultivation of V. cholerae eltor under the conditions of high salt concentration, as well as low temperature and deficiency in nutrient substances, uncultivable forms (UF) of toxigenic and nontoxigenic vibrios were obtained. The absence of growth
Chia-Ming Yeh et al.
International journal of oncology, 45(5), 2101-2107 (2014-09-02)
Ovarian cancer is the fifth leading cause of cancer death and the most deadly gynecological malignancy in women. Epigenetic modifications play an important role in regulating gene transcription. Specifically, aberrant promoter hypermethylation has been implicated as a hallmark of cancer.
Fang Yu et al.
Cancer letters, 368(1), 135-143 (2015-08-12)
Interferon-induced transmembrane protein 1 (IFITM1) is one of the interferon-induced transmembrane protein family members. In this study, we reported that the elevated IFITM1 expression in human colorectal cancer (CRC) significantly correlated with CRC lymph node and distance metastasis as well
Jinghui Zhang et al.
Cancer investigation, 33(5), 165-171 (2015-04-02)
This study demonstrated that miR-21 and miR-95 expression were significantly higher in the ALDH1(+)CD133(+)subpopulation than in the ALDH1(-)CD133(-) subpopulation of lung cancer cells. Combined delivery of anti-miR-21 and anti-miR-95 by calcium phosphate nanoparticles significantly inhibited tumor growth in a xenograft
Mwinyikione Mwinyihija et al.
Archives of environmental contamination and toxicology, 50(3), 316-324 (2006-01-05)
A study was conducted to investigate the sediment health and water quality of the River Sagana, Kenya, as impacted by the local tanning industry. Chemical analysis identified the main chemical pollutants (pentachlorophenols and chromium) while a bioassay addressed pollutant bioavailability.
Teng Chang et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 103(3), 539-547 (2014-06-18)
Hemocompatibility of genistein-modified poly(ethersulfone)/poly(vinylpyrrolidone) (PES/PVP) hemodialysis (HD) membranes has been investigated in vitro with emphasis on evaluation of cell viability, antioxidant, anti-inflammatory, and antiplatelet adhesion properties. Genistein modified PES/PVP membranes reveal significant reduction of the reactive oxygen species and also
Ruiwu Wang et al.
Insect biochemistry and molecular biology, 33(7), 733-739 (2003-06-27)
Voltage-gated sodium channels are essential for the generation and propagation of action potentials in most excitable cells. They are the target sites of several classes of insecticides and acaricides. Isolation of full-length sodium channel cDNA is a critical and often
Thomas P Burke et al.
Nature microbiology, 5(5), 688-696 (2020-03-04)
The innate immune system fights infection with inflammasomes and interferons. Facultative bacterial pathogens that inhabit the host cytosol avoid inflammasomes1-6 and are often insensitive to type I interferons (IFN-I), but are restricted by IFN-γ7-11. However, it remains unclear how obligate
Sungwon Han et al.
Journal of microbiological methods, 90(3), 206-210 (2012-05-19)
As glutamate and ammonia play a pivotal role in nitrogen homeostasis, their production is mediated by various enzymes that are widespread in living organisms. Here, we report on an effective electrophoretic method to monitor these enzymes. The in gel activity
Satoshi Okada et al.
Journal of medical genetics, 44(8), 485-491 (2007-05-22)
Patients with interferon-gamma receptor 1 (IFNgammaR1) deficiency show selective susceptibility to intracellular pathogens such as mycobacteria. IFNgammaR1 deficiency is an inherited immunodeficiency disorder, which can be either recessive or dominant. Dominant forms of IFNgammaR1 deficiency are known to be associated
Yang Hongwei et al.
Ecotoxicology and environmental safety, 53(3), 416-421 (2002-12-18)
This study assessed anaerobic biodegradability of organic compounds from microorganism activity. Dehydrogenase activity can be a good parameter characterizing the microorganism activity. A modified method of 2-(p-iodophenyl-3-(p-nitrophenyl)-5-pheny tetrazolium chloride-dehydrogenase activity determination was proposed in anaerobic biodegradability assessment. Cubic spline curves
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