Showing 1-30 of 1036 results for "I9030"
Mutasem Rawas-Qalaji et al.
The Journal of pharmacy and pharmacology, 67(1), 20-25 (2014-09-27)
For anaphylaxis treatment in community settings, adrenaline (epinephrine) administration using an auto-injector in the thigh is universally recommended. Despite this, many people at risk of anaphylaxis in community settings do not carry their prescribed auto-injectors consistently and hesitate to use...
Thomas Sherman et al.
Clinical orthopaedics and related research, 473(1), 351-357 (2014-08-29)
Therapeutic musculoskeletal injections require a clean or sterile skin preparation to minimize the risk of infections. Ultrasound guidance for this procedure requires the use of transmission gel in proximity to the injection site, and its effect on maintaining sterility is...
Shancheng Zhao et al.
Carbohydrate research, 401, 32-38 (2014-12-03)
Heparan sulfate is a component of the extracellular matrix (ECM) that modulates individual development and cell growth through its interaction with growth factors. Structurally, heparan sulfate consists of repeating linear sulfated poly-anionic disaccharide structures. The K5 polysaccharide has the same...
A Viola et al.
Magma (New York, N.Y.), 17(1), 47-61 (2004-09-02)
Cerebral metabolic changes that concur to motor and/or cognitive disorders in actively drinking alcoholics are not well established. We tested the hypothesis that chronic alcoholics exhibit profound alterations in the cerebral metabolism of scyllo-inositol. Brain metabolism was explored in nine...
Dengteng Ge et al.
Advanced materials (Deerfield Beach, Fla.), 27(15), 2489-2495 (2015-03-04)
A smart window is fabricated from a composite consisting of elastomeric poly(dimethylsiloxane) embedded with a thin layer of quasi-amorphous silica nanoparticles. The smart window can be switched from the initial highly transparent state to opaqueness and displays angle-independent structural color...
Xizheng Yan et al.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 17(11), 1324-1330 (2015-02-05)
We developed a high throughput method for estimating smoker's mainstream smoke intake on a per-cigarette basis by analyzing discarded cigarette butts. This new method utilizes ultraviolet/visible (UV-Vis) spectrophotometric analysis of isopropanol-soluble smoke particulate matter extracted from discarded cigarette filters. When...
Christopher T Frenz et al.
Journal of neurophysiology, 112(5), 1091-1104 (2014-05-30)
Olfactory sensory neurons (OSNs) fire spontaneously as well as in response to odor; both forms of firing are physiologically important. We studied voltage-gated Na(+) channels in OSNs to assess their role in spontaneous activity. Whole cell patch-clamp recordings from OSNs...
María Segovia et al.
Photochemistry and photobiology, 91(6), 1389-1402 (2015-08-01)
The effect of different ultraviolet radiation (UVR) treatments combining PAR (P), UVA (A) and UVB (B) on the molecular physiology of Dunaliella tertiolecta was studied during 6 days to assess the response to chronic UVR exposure. UVR reduced cell growth...
Yulia Lazra et al.
Journal of cellular biochemistry, 116(5), 754-766 (2014-12-11)
Adiponectin is an adipose-derived hormone, with beneficial effects on insulin sensitivity and inflammation. The aim of this study was to clarify the autocrine/paracrine effects of globular adiponectin (gAd) administrated during differentiation on the function of the mature adipocytes. Experiments were...
Catherine A VandeVoort et al.
Physiological genomics, 47(4), 102-112 (2015-01-15)
Oocytes isolated from female rhesus monkeys following standard ovarian stimulation protocols during the summer months displayed a reduced capacity to mature compared with stimulation during the normal breeding season. Because the gene expression profiles of oocyte-associated cumulus cells and mural...
Tuoen Liu et al.
Cancer letters, 357(1), 231-241 (2014-12-03)
We previously identified and characterized a 66-68 kDa membrane-associated, tyrosine phosphorylated protein in murine leukemia L1210 cells as HSC70 which is a methotrexate (MTX)-binding protein. In order to further characterize the functional role of HSC70 in regulating MTX resistance in L1210...
Aditya Pandey et al.
Biochemistry and cell biology = Biochimie et biologie cellulaire, 92(4), 269-278 (2014-06-20)
G-protein coupled receptors (GPCRs) are inherently dynamic membrane protein modulators of various important cellular signaling cascades. The apelin receptor (AR or APJ) is a class A GPCR involved in numerous physiological processes, implicated in angiogenesis during tumour formation and as...
Betina Tabah et al.
ChemSusChem, 8(20), 3497-3503 (2015-09-10)
A solar reactor was designed to perform the conversion of starch to ethanol in a single step. An aqueous starch solution (5 wt %) was fed into the reactor bed charged with Baker's yeast (Saccharomyces cerevisiae) and amylase, resulting in approximately 2.5 wt %...
Marc-Antoine Lauzon et al.
Tissue engineering. Part A, 20(17-18), 2524-2535 (2014-03-07)
The bone morphogenetic proteins (BMPs) are potent osteogenic molecules that are used for bone repair in delivery systems and in regenerative medicine. We studied the responses of murine MC3T3-E1 preosteoblasts to doses of recombinant human (rh)BMP-9 with and without fetal...
Michael K L Chu et al.
Diabetes technology & therapeutics, 17(4), 255-267 (2015-02-12)
An implantable, glucose-responsive insulin delivery microdevice was reported previously by our group, providing rapid insulin release in response to hyperglycemic events and efficacy in vivo over a 1-week period when implanted intraperitoneally in rats with diabetes. Herein, we focused on...
Sarah S Poulsen et al.
Toxicology and applied pharmacology, 283(3), 210-222 (2015-01-27)
Adverse lung effects following pulmonary exposure to multi-walled carbon nanotubes (MWCNTs) are well documented in rodents. However, systemic effects are less understood. Epidemiological studies have shown increased cardiovascular disease risk after pulmonary exposure to airborne particles, which has led to...
S Wittmann et al.
Blutalkohol, 29(5), 326-335 (1992-09-01)
After preoperative skin disinfection in pediatric surgery, serum levels of isopropanol up to 12.2 mg/l (MW 5.0 mg/l +/- 3.37, n = 26) were found. They result from a rapid and prolonged but uncharacteristic percutaneous resorption of the isopropanol-containing disinfectant....
Joohyung Lee et al.
Langmuir : the ACS journal of surfaces and colloids, 31(44), 11989-11999 (2015-10-21)
Electric charging of colloidal particles in nonpolar solvents plays a crucial role for many industrial applications and products, including rubbers, engine oils, toners, or electronic displays. Although disfavored by the low solvent permittivity, particle charging can be induced by added...
Xiaohua Yu et al.
Journal of controlled release : official journal of the Controlled Release Society, 191, 47-53 (2014-05-24)
Intimal hyperplasia produces restenosis (re-narrowing) of the vessel lumen following vascular intervention. Drugs that inhibit intimal hyperplasia have been developed, however there is currently no clinical method of perivascular drug-delivery to prevent restenosis following open surgical procedures. Here we report...
Xu Chen et al.
Scientific reports, 5, 16246-16246 (2015-11-06)
For the first time a novel oxygen reduction catalyst with a 3D platinized graphene/nano-ceramic sandwiched architecture is successfully prepared by an unusual method. Herein the specific gravity of graphene nanosheets (GNS) is tailored by platinizing graphene in advance to shorten...
David Leitsch et al.
Experimental parasitology, 134(3), 374-380 (2013-04-13)
Our previous observation that NADP-dependent secondary alcohol dehydrogenase (ADH-1) is down-regulated in metronidazole-resistant Trichomonas vaginalis isolates prompted us to further characterise the enzyme. In addition to its canonical enzyme activity as a secondary alcohol dehydrogenase, a pronounced, so far unknown...
T Sathyapalan et al.
Scientific reports, 5, 16890-16890 (2015-11-20)
MicroRNAs (miRNA) are a novel class of small noncoding single-stranded RNA molecules that regulate gene expression. There is increasing evidence of their importance in polycystic ovary syndrome (PCOS). The objective was to determine if miRNA-93 and miRNA-223 are differentially expressed...
Kayla A Martin et al.
Molecular and cellular biology, 35(23), 3934-3944 (2015-09-16)
Posttranslational modifications, such as poly(ADP-ribosyl)ation (PARylation), regulate chromatin-modifying enzymes, ultimately affecting gene expression. This study explores the role of poly(ADP-ribose) polymerase (PARP) on global gene expression in a lymphoblastoid B cell line. We found that inhibition of PARP catalytic activity...
Dong-Ryung Lee et al.
Asian Pacific journal of tropical medicine, 8(11), 898-906 (2015-11-29)
To investigate the anti-obesity activity and the action mechanism of the roots of Adenophora triphylla var. japonica extract (ATE) in high-fat diet (HFD)-induced obese mice and 3T3-L1 adipocytes. The roots of Adenophora triphylla were extracted with 70% ethanol. To demonstrate...
A Santarelli et al.
Journal of biological regulators and homeostatic agents, 28(3), 523-529 (2014-10-16)
Calcium phosphate ceramics have been applied in bone replacement for several decades due to their excellent biocompatibility, bioactivity, osteo-conductivity and mechanical strength. Several studies have demonstrated that porous hydroxyapatite (HA) is an excellent scaffold for osteogenic proliferation and differentiation of...
Marilène Binsfeld et al.
PloS one, 9(11), e113764-e113764 (2014-11-22)
Multiple myeloma (MM) is a malignant plasma cell disorder with poor long-term survival and high recurrence rates. Despite evidence of graft-versus-myeloma (GvM) effects, the use of allogeneic hematopoietic stem cell transplantation (allo-SCT) remains controversial in MM. In the current study...
Cui-Wei Wang et al.
Molecular medicine reports, 11(3), 1885-1890 (2014-11-15)
The present study aimed to prepare perfluoropropane (C3F8)-filled poly(lactic-co-glycolic acid) (PLGA) nanoparticles and investigate the feasibility of using PLGA nanoparticles as an ultrasound contrast agent. The PLGA nanoscale ultrasound contrast agent was prepared using a modified double-emulsion solvent evaporation method....
Katharina Wittmann et al.
Tissue engineering. Part A, 21(7-8), 1343-1353 (2015-01-21)
The development of vascularized and functional adipose tissue substitutes is required to improve soft tissue augmentation. In this study, vascularized adipose tissue constructs were generated using uncultured cells from the stromal-vascular fraction (SVF) of adipose tissue as an alternative cell...
One-step MIBK synthesis: a new process from 2-propanol.
Di Cosimo JI, et al.
J. Catal., 208(1), 114-123 (2002)
Daryn Goodwin et al.
Bioorganic & medicinal chemistry, 22(17), 4848-4854 (2014-07-26)
Active immunisation against gonadotropin releasing hormone (GnRH) is a potential alternative to surgical castration. This study focused on the development of a GnRH subunit lipopeptide vaccine. A library of vaccine candidates that contained one or more (up to eight) copies...

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