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Xinmin Zhao et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 36(9), 6733-6740 (2015-04-03)
Lung cancer is the leading cause of cancer-related death in the world. Previous report has identified ribosomal protein s15a (RPS15A) as a TGF-β-responsible gene in the lung adenocarcinoma cell line A549. In this study, we used specific si-RNA to downregulate
Malia Su-Qin Murphy et al.
American journal of obstetrics and gynecology, 213(6), 853-853 (2015-10-18)
The long-term maternal cardiovascular and metabolic implications associated with preeclampsia (PE) include risk of hypertension, heart disease, and metabolic syndrome. The objective of this study was to investigate if a recent history of PE was associated with detectable alterations in
Cédric Maerckx et al.
World journal of gastroenterology, 20(30), 10553-10563 (2014-08-19)
To test the ability of adult-derived human liver stem/progenitor cells (ADHLSC) from large scale cultures to conjugate bilirubin in vitro and in bilirubin conjugation deficient rat. ADHLSC from large scale cultures were tested for their phenotype and for their capacity
L J Fry et al.
Vox sanguinis, 109(2), 181-190 (2015-04-23)
Advantages of using cord blood (CB) over other sources of haematopoietic progenitor cells, such as bone marrow, include the ability to cryopreserve and bank the samples until requested for a transplant. Cryopreservation requires the addition of a cryoprotectant to prevent
Yipeng Ren et al.
Fish & shellfish immunology, 47(1), 110-116 (2015-09-04)
Serine protease inhibitors (SPIs) are an important group of protease inhibitors involved in a variety of biological processes. In the present study, a Kazal-type serine protease inhibitor homolog gene (designated as CsKPI) was identified from a Cyclina sinensis cDNA library.
Sambrook, J., et al.
Molecular Cloning: A Laboratory Manual, E-E (1989)
Martha L Slattery et al.
BMC medicine, 13, 75-75 (2015-04-19)
Studies of colorectal cancer (CRC) have shown that hundreds to thousands of genes are differentially expressed in tumors when compared to normal tissue samples. In this study, we evaluate how genes that are differentially expressed in colon versus normal tissue
Rosica S Petrova et al.
Experimental eye research, 132, 124-135 (2015-01-18)
The expression of the water channel protein aquaporin (AQP)-5 in adult rodent and human lenses was recently reported using immunohistochemistry, molecular biology, and mass spectrometry techniques, confirming a second transmembrane water channel that is present in lens fibre cells in
Gabriel A Goldfien et al.
Reproductive sciences (Thousand Oaks, Calif.), 22(7), 814-828 (2015-01-31)
Epidemiological studies indicate that progestin-containing contraceptives increase susceptibility to HIV, although the underlying mechanisms involving the upper female reproductive tract are undefined. To determine the effects of depot medroxyprogesterone acetate (DMPA) and the levonorgestrel intrauterine system (LNG-IUS) on gene expression
Magdalene H Y Tang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 969, 272-284 (2014-09-10)
Novel psychoactive substances (NPS) are becoming increasingly popular worldwide in recent years, some of which have been reported to cause considerable harm and even fatalities. Currently, simultaneous screening for a comprehensive panel of conventional and novel drugs of abuse is
Corina Danciu et al.
Natural product communications, 10(6), 951-954 (2015-07-23)
In recent years polyurethane microstructures (PM) have gained increasing attention in the pharmaceutical field due to the importance of their practical application. Since finding that such a formulation with genistein could improve its applications, we have conducted a preliminary study
Ferran Jardi et al.
Journal of neurogastroenterology and motility, 21(2), 222-235 (2015-04-07)
Enteric dysbiosis is a risk factor for dietary proteins-associated intestinal alterations, contributing to the development of food allergies and the symptomatology of functional gastrointestinal disorders, mainly irritable bowel syndrome (IBS). We explored if a dysbiotic-like state, simulated by intraperitoneal administration
D G Bailey et al.
Journal of chromatography, 111(2), 305-311 (1975-09-03)
A method is presented for the measurement of 6-mercaptopurine (6-MP) in serum. Serum samples containing the drug were treated with dithioerythritol and saturated with ammonium carbonate. 6-MP was then extracted from the serum with a mixture of isopropanol-ethyl acetate (1:1
Oscar Cordero-Llana et al.
Experimental neurology, 256, 93-104 (2014-04-15)
Galanin is a pleiotropic neuropeptide widely expressed in the nervous system. It plays a role in many diverse physiological functions - including nociception, cognition and metabolism regulation - and acts as neurotrophic/neuroprotective factor for several neuronal populations. In this article
Wei-Ting Huang et al.
Molecular pharmaceutics, 12(4), 1242-1249 (2015-03-12)
Targeting controlled release core-shell nanocarriers with the potential to overcome multidrug resistant (MDR) lung cancer were prepared based on demethoxycurcumin (DMC) loaded amphiphilic chitosan nanoparticles coated with an anti-EGFR antibody layer. The nanocarriers were characterized with regard to size with
Ravinder Kaur et al.
Disease models & mechanisms, 8(10), 1295-1309 (2015-09-24)
Medulloblastoma (MB) is the most common malignant primary pediatric brain tumor and is currently divided into four subtypes based on different genomic alterations, gene expression profiles and response to treatment: WNT, Sonic Hedgehog (SHH), Group 3 and Group 4. This
S Wei et al.
Journal of animal science, 93(3), 1015-1024 (2015-05-29)
Japanese Wagyu cattle are well known for their extremely high marbling and lower subcutaneous adipose tissue compared with Angus cattle. However, mechanisms for differences in adipose deposition are unknown. The objective of this paper was to evaluate breed differences in
Stergios Kechagias et al.
Alcohol and alcoholism (Oxford, Oxfordshire), 50(4), 399-406 (2015-04-18)
It is generally agreed that traditional alcohol biomarkers lack in sensitivity to detect hazardous alcohol consumption. The present study was undertaken to evaluate the ability of phosphatidylethanol (PEth) and traditional alcohol markers to detect moderate alcohol consumption and to distinguish
Yinhua Ni et al.
Scientific reports, 5, 17192-17192 (2015-11-26)
Hepatic insulin resistance and nonalcoholic steatohepatitis (NASH) could be caused by excessive hepatic lipid accumulation and peroxidation. Vitamin E has become a standard treatment for NASH. However, astaxanthin, an antioxidant carotenoid, inhibits lipid peroxidation more potently than vitamin E. Here
Mohammad Fallahi et al.
PloS one, 9(12), e115517-e115517 (2014-12-30)
The RNA-binding protein Tristetraprolin (TTP, ZFP36) functions as a tumor suppressor that impairs the development and disables the maintenance of MYC-driven lymphoma. In addition, other human cancers expressed reduced levels of TTP, suggesting that it may function as a tumor
Peter C Grayson et al.
Arthritis & rheumatology (Hoboken, N.J.), 67(8), 2233-2239 (2015-05-06)
To determine whether disease processes related to granulomatosis with polyangiitis (Wegener's) (GPA) are reflected in gene expression profiles of the nasal mucosa. Nasal brushings of the inferior turbinate were obtained from 32 patients with GPA (10 with active nasal disease
Feng Zhang et al.
Nature communications, 5, 5815-5815 (2014-12-19)
Lysine-specific demethylase 1 (LSD1) is involved in gene regulation and development; however, its precise function, molecular targets and underlying mechanisms during development are poorly understood. Here we show that LSD1 is required for neuronal progenitor cell (NPC) maintenance during cortical
Kommireddy Vasu et al.
STAR protocols, 2(4), 100785-100785 (2021-09-30)
CRISPR-Cas9-mediated, site-directed mutagenesis in mice generates mosaic founder mice with varied efficiency of desired point mutation and other non-homologous end-joined variants. Here, we present a protocol for design, sample preparation, and analysis for identification of mice with the desired mutation.
Lu Li et al.
Small (Weinheim an der Bergstrasse, Germany), 11(26), 3162-3173 (2015-03-11)
Engineering novel theranostic agents with both imaging and therapeutic functions have profound impact on molecular diagnostics, imaging, and therapeutics. In this paper, we develop for the first time a simple, scalable, and reproducible route to synthesize novel multifunctional spherical Au
Steven N Steinway et al.
PloS one, 10(5), e0128159-e0128159 (2015-05-23)
c-Met, a high-affinity receptor for Hepatocyte Growth Factor (HGF), plays a critical role in tumor growth, invasion, and metastasis. Hepatocellular carcinoma (HCC) patients with activated HGF/c-Met signaling have a significantly worse prognosis. Targeted therapies using c-Met tyrosine kinase inhibitors are
Zhenyang Si et al.
International archives of allergy and immunology, 182(10), 997-1007 (2021-08-25)
Cough-variant asthma (CVA) is a special type of asthma, solely manifesting with coughing. Studies suggest that airway inflammation is associated with CVA pathogenesis. Amygdalin is found to have an anti-inflammatory potential, while how it affects CVA remains unexplored. Cytotoxicity delivered
Sofie Trier et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 96, 329-337 (2015-09-09)
Acylation of peptide drugs with fatty acid chains has proven beneficial for prolonging systemic circulation, as well as increasing enzymatic stability and interactions with lipid cell membranes. Thus, acylation offers several potential benefits for oral delivery of therapeutic peptides, and
Shu Xia et al.
Oncotarget, 6(18), 16411-16421 (2015-04-29)
Liquid biopsies, examinations of tumor components in body fluids, have shown promise for predicting clinical outcomes. To evaluate tumor-associated genomic and genetic variations in plasma cell-free DNA (cfDNA) and their associations with treatment response and overall survival, we applied whole
Harumi Uto-Kondo et al.
Biochimica et biophysica acta, 1841(9), 1247-1255 (2014-07-06)
Reverse cholesterol transport (RCT) is pivotal in the return of excess cholesterol from peripheral tissues to the liver for excretion in bile and eventually feces. RCT from macrophages is a critical anti-atherogenicity mechanism of HDL. As the cholesterol absorption inhibitor
Olesya Chayka et al.
The Journal of biological chemistry, 290(4), 2198-2212 (2014-12-06)
The MYC family of transcription factors consists of three well characterized members, c-MYC, L-MYC, and MYCN, deregulated in the majority of human cancers. In neuronal tumors such as neuroblastoma, MYCN is frequently activated by gene amplification, and reducing its expression
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