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IP50

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Per Svenningsen et al.
Pflugers Archiv : European journal of physiology, 466(12), 2205-2214 (2014-03-15)
Voltage-gated calcium channels are involved in the vascular excitation-contraction mechanism and regulation of arterial blood pressure. It was hypothesized that T-type channels promote formation of nitric oxide from the endothelium. The present experiments determine the involvement of T-type channels in...
Clara-Zoe Wende et al.
PloS one, 10(5), e0127681-e0127681 (2015-05-21)
GABAergic neurons are the primary inhibitory cell type in the mature brain and their dysfunction is associated with important neurological conditions like schizophrenia and anxiety. We aimed to discover the underlying mechanisms for dorsal/ventral midbrain GABAergic neurogenesis. Previous work by...
Cátia Santos-Pereira et al.
International journal of biological macromolecules, 171, 343-357 (2021-01-10)
Lactoferrin (Lf) is a bioactive milk-derived protein with remarkable wide-spectrum antifungal activity. To deepen our understanding of the molecular mechanisms underlying Lf cytotoxicity, the role of plasma membrane ergosterol- and sphingolipid-rich lipid rafts and their association with the proton pump...
Ali Nawshad et al.
Journal of cell science, 120(Pt 9), 1646-1653 (2007-04-25)
Dissociation of medial-edge epithelium (MEE) during palate development is essential for mediating correct craniofacial morphogenesis. This phenomenon is initiated by TGFbeta3 upon adherence of opposing palatal shelves, because loss of E-cadherin causes the MEE seam to break into small epithelial...
Robert Meller et al.
The Journal of biological chemistry, 281(11), 7429-7436 (2006-01-25)
A previous exposure to a non-harmful ischemic insult (preconditioning) protects the brain against subsequent harmful ischemia (ischemic tolerance). In contrast to delayed gene-mediated ischemic tolerance, little is known about the molecular mechanisms that regulate rapid ischemic tolerance, which occurs within...
Lisa M Bank et al.
Development (Cambridge, England), 139(24), 4666-4674 (2012-11-23)
This study is the first to demonstrate that macrophage migration inhibitory factor (MIF), an immune system 'inflammatory' cytokine that is released by the developing otocyst, plays a role in regulating early innervation of the mouse and chick inner ear. We...
Patricia Workman et al.
Journal of bacteriology, 194(13), 3512-3521 (2012-05-01)
The BamA protein of Escherichia coli plays a central role in the assembly of β-barrel outer membrane proteins (OMPs). The C-terminal domain of BamA folds into an integral outer membrane β-barrel, and the N terminus forms a periplasmic polypeptide transport-associated...
R Meller et al.
Epilepsy research, 70(1), 3-14 (2006-03-18)
In response to harmful stresses, cells induce programmed cell death (PCD) or apoptosis. Seizures can induce neural damage and activate biochemical pathways associated with PCD. Since seizures trigger intracellular calcium overload, it has been presumed that the intrinsic cell death...
Ganesh K Maurya et al.
Microbiology (Reading, England), 162(8), 1321-1334 (2016-07-03)
The Deinococcus radiodurans genome encodes many of the known components of divisome as well as four sets of genome partitioning proteins, ParA and ParB on its multipartite genome. Interdependent regulation of cell division and genome segregation is not understood. In...
Heather M Moore et al.
Breast cancer research and treatment, 138(3), 741-752 (2013-03-30)
EZH2 is a Polycomb group protein that exerts oncogenic functions in breast cancer, where its overexpression is associated with metastatic disease. While it reportedly acts a transcriptional repressor through trimethylation of histone H3 at lysine 27, EZH2 may exhibit context-dependent...
Attenuated PGI2 synthesis in obese Zucker rats
Hodnett,B et al.
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 296(3), R715-R721 (2010)
Signal Transduction Protein Array Analysis Links LRRK2 to Ste20 Kinases and PKC Zeta That Modulate Neuronal Plasticity
Zach,S et al.
PLoS ONE, 5(10) (2010)
G-protein alpha-s and -12 subunits are involved in androgen-stimulated PI3K activation and androgen receptor transactivation in prostate cancer cells
Liu,J et al.
Prostate (2011)
H Jacob Hanchar et al.
Proceedings of the National Academy of Sciences of the United States of America, 103(22), 8546-8551 (2006-04-04)
Although GABA(A) receptors have long been implicated in mediating ethanol (EtOH) actions, receptors containing the "nonsynaptic" delta subunit only recently have been shown to be uniquely sensitive to EtOH. Here, we show that delta subunit-containing receptors bind the imidazo-benzodiazepines (BZs)...
Ting Liu et al.
Frontiers in immunology, 10, 2952-2952 (2020-01-11)
We previously reported that astrocyte-derived proinflammatory cytokine interleukin (IL)-17A could aggravate neuronal ischemic injuries and strength autophagy both in oxygen-glucose deprivation (OGD)/reoxygenation (R)-treated neurons and peri-infarct region of mice with middle cerebral artery occlusion (MCAO)/reperfusion (R)-simulated ischemic stroke. In this...
Drew Bennion et al.
Molecular microbiology, 77(5), 1153-1171 (2010-07-06)
BamA of Escherichia coli is an essential component of the hetero-oligomeric machinery that mediates β-barrel outer membrane protein (OMP) assembly. The C- and N-termini of BamA fold into trans-membrane β-barrel and five soluble POTRA domains respectively. Detailed characterization of BamA...
Phu Vuong et al.
Journal of bacteriology, 190(5), 1507-1517 (2008-01-01)
In Escherichia coli, YaeT, together with four lipoproteins, YfgL, YfiO, NlpB, and SmpA, forms a complex that is essential for beta-barrel outer membrane protein biogenesis. Data suggest that YfgL and YfiO make direct but independent physical contacts with YaeT. Whereas...
Tiago De Oliveira et al.
Molecular cancer, 11, 19-19 (2012-04-05)
We have identified syndecan-2 as a protein potentially involved in perineural invasion of pancreatic adenocarcinoma (PDAC) cells. Syndecan-2 (SDC-2) expression was analyzed in human normal pancreas, chronic pancreatitis and PDAC tissues. Functional in vitro assays were carried out to determine...
Andrew J Conley et al.
BMC biology, 7, 48-48 (2009-08-12)
Elastin-like polypeptides are synthetic biopolymers composed of a repeating pentapeptide 'VPGXG' sequence that are valuable for the simple non-chromatographic purification of recombinant proteins. In addition, elastin-like polypeptide fusions have been shown to enhance the accumulation of a range of different...
Weixing Shen et al.
Cell cycle (Georgetown, Tex.), 9(23), 4720-4734 (2010-11-26)
Mechanisms of cAMP/PKA-induced meiotic arrest in oocytes are not completely identified. In cultured, G2/M-arrested PDE3A(-/-) murine oocytes, elevated PKA activity was associated with inactivation of Cdc2 and Plk1, and inhibition of phosphorylation of histone H3 (S10) and of dephosphorylation of...
Hubert Arokium et al.
The Journal of biological chemistry, 282(48), 35104-35112 (2007-10-04)
During apoptosis, the pro-apoptotic protein Bax relocalizes from the cytosol to the mitochondrial outer membrane. This relocalization is associated to major conformational changes, namely at the N- and C-terminal ends of the protein. Substitution of residues located at critical positions...
F Gautier et al.
Molecular and cellular biology, 31(4), 832-844 (2010-12-22)
Bcl-2 homologues (such as Bcl-x(L)) promote survival in part through sequestration of "activator" BH3-only proteins (such as Puma), preventing them from directly activating Bax. It is thus assumed that inhibition of interactions between activators and Bcl-x(L) is a prerequisite for...
Wei Liu et al.
Frontiers in genetics, 5, 228-228 (2014-08-08)
Many flowering plants adopt self-incompatibility (SI) to maintain their genetic diversity. In species of Solanaceae, Plantaginaceae, and Rosaceae, SI is genetically controlled by a single S-locus with multiple haplotypes. The S-locus has been shown to encode S-RNases expressed in pistil...
R Meller et al.
Cell death and differentiation, 10(5), 539-547 (2003-05-03)
Seizure-induced neuronal death may involve engagement of the BCL-2 family of apoptosis-regulating proteins. In the present study we examined the activation of proapoptotic BAD in cultured hippocampal neurons following seizures induced by removal of chronic glutamatergic transmission blockade. Kynurenic acid...
Amanda Henry et al.
FEMS microbiology letters, 336(2), 139-147 (2012-10-23)
Yersinia polynucleotide phosphorylase (PNPase), a 3'-5' exoribonuclease, has been shown to affect growth during several stress responses. In Escherichia coli, PNPase is one of the subunits of a multiprotein complex known as the degradosome, but also has degradosome-independent functions. The...
Veronica J Jessick et al.
International journal of physiology, pathophysiology and pharmacology, 5(4), 216-227 (2014-01-01)
Neuronal morphology is highly sensitive to ischemia, although some re-organization may promote neuroprotection. In this study we investigate the role of actin regulating proteins (ARP2, ARP3 and WAVE-1) and their role in rapid ischemic tolerance. Using an established in vitro...
Peter J Eastmond
The Plant cell, 19(4), 1376-1387 (2007-04-24)
Hydrogen peroxide is a major by-product of peroxisomal metabolism and has the potential to cause critical oxidative damage. In all eukaryotes, catalase is thought to be instrumental in removing this H(2)O(2). However, plants also contain a peroxisomal membrane-associated ascorbate-dependent electron...
Kong-Hung Sze et al.
Cell chemical biology, 24(2), 182-194 (2017-01-24)
Talaromyces (Penicillium) marneffei is one of the leading causes of systemic mycosis in immunosuppressed or AIDS patients in Southeast Asia. How this intracellular pathogen evades the host immune defense remains unclear. We provide evidence that T. marneffei depletes levels of a...
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