Search Within
Applied Filters:
Showing 1-30 of 256 results for "


" within Papers
Megan Culbreth et al.
Toxicology in vitro : an international journal published in association with BIBRA, 63, 104717-104717 (2019-11-11)
Methylmercury (MeHg) is a pervasive environmental toxicant, with known detrimental effects on neurodevelopment. Despite a longstanding paradigm of neurotoxicity, where motor deficits are prevalent among those developmentally exposed, consideration of muscle as a MeHg target has received minimal investigation. Recent...
Inmaculada Couso et al.
The Plant cell, 32(1), 69-80 (2019-11-13)
Target of rapamycin complex 1 (TORC1) is a central regulator of cell growth. It balances anabolic and catabolic processes in response to nutrients, growth factors, and energy availability. Nitrogen- and carbon-containing metabolites have been shown to activate TORC1 in yeast...
Reinhard David et al.
The European journal of neuroscience, 31(6), 978-993 (2010-04-10)
Nicotinic acetylcholine receptors (nAChRs) mediate fast synaptic transmission in ganglia of the autonomic nervous system. Here, we determined the subunit composition of hetero-pentameric nAChRs in the mouse superior cervical ganglion (SCG), the function of distinct receptors (obtained by deletions of...
J Wang et al.
Neoplasma, 67(1), 61-67 (2019-11-30)
The present study aimed to assess the association of rs34000982 polymorphism located in the 3'untranslated region (3'UTR) of high mobility group box 1 (HMGB1) gene and the risk of hepatocellular carcinoma (HCC), and further to explore the underlying mechanism. Genomic...
Shiqi Wang et al.
International journal of molecular sciences, 20(24) (2019-12-19)
Acupuncture is widely recognized as an effective therapy for premature ovarian failure (POF) in clinical, but information about its potential mechanisms is rarely explored. To investigate the mechanism, fifty SD female rats were randomly divided into normal group, POF group...
Behzad Nasseri et al.
International immunopharmacology, 84, 106546-106546 (2020-05-16)
Apelin is a neuropeptide that plays an important role in neuronal protection. In this study, we investigated the effects of apelin intracerebroventricular administration on spatial learning and memory-related behaviors, and necroptosis signaling pathways in the hippocampus of streptozotocin (STZ) -injected...
Interactions between Brucella suis VirB8 and its homolog TraJ from the plasmid pSB102 underline the dynamic nature of type IV secretion systems.
Bourg, Gisele, et al.
Journal of Bacteriology, 191, 2985-2992 (2009)
John Y S Han et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(4), 5401-5419 (2020-03-01)
The neural retina metabolizes glucose through aerobic glycolysis generating large amounts of lactate. Lactate flux into and out of cells is regulated by proton-coupled monocarboxylate transporters (MCTs), which are encoded by members of the Slc16a family. MCT1, MCT3, and MCT4...
S M Bakhtiar Ul Islam et al.
Cancers, 12(1) (2020-01-23)
Oncolytic viruses are a promising class of anti-tumor agents; however, concerns regarding uncontrolled viral replication have led to the development of a replication-controllable oncolytic vaccinia virus (OVV). The engineering involves replacing the native thymidine kinase (VV-tk) gene, in a Wyeth...
Luiz Eduardo Baggio Savio et al.
Journal of cell science, 133(5) (2020-02-02)
Macrophages are tissue-resident immune cells that are crucial for the initiation and maintenance of immune responses. Purinergic signaling modulates macrophage activity and impacts cellular plasticity. The ATP-activated purinergic receptor P2X7 (also known as P2RX7) has pro-inflammatory properties, which contribute to...
Thomson Patrick Joseph et al.
Frontiers in neuroscience, 14, 458-458 (2020-06-18)
Besides several endogenous elements, exogenous factors, including exposure to pesticides, have been recognized as putative factors contributing to the onset and development of neurodegenerative diseases, including Parkinson's disease (PD). Considering the availability, success rate, and limitations associated with the current...
Yuyan Fan et al.
BMC complementary and alternative medicine, 19(1), 355-355 (2019-12-07)
Astragaloside IV (AS-IV) was reported to play a role in improving diabetic nephropathy (DN), however, the underlying mechanisms still remain unclear. The aim of the present study is to investigate whether AS-IV ameliorates DN via the regulation of endothelial nitric...
Alba Rodriguez-Garcia et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 28(2), 548-560 (2019-12-25)
The prognosis of patients diagnosed with advanced ovarian or endometrial cancer remains poor, and effective therapeutic strategies are limited. The Müllerian inhibiting substance type 2 receptor (MISIIR) is a transforming growth factor β (TGF-β) receptor family member, overexpressed by most...
Jia-Feng Chang et al.
Toxins, 12(6) (2020-06-06)
The nephrotoxicity of aristolochic acids (AAs), p-cresyl sulfate (PCS) and indoxyl sulfate (IS) were well-documented, culminating in tubulointerstitial fibrosis (TIF), advanced chronic kidney disease (CKD) and fatal urothelial cancer. Nonetheless, information regarding the attenuation of AAs-induced nephropathy (AAN) and uremic...
Vera D Rinaldi et al.
Genetics, 215(2), 373-378 (2020-04-11)
Eukaryotic organisms have evolved mechanisms to prevent the accumulation of cells bearing genetic aberrations. This is especially crucial for the germline, because fecundity and fitness of progeny would be adversely affected by an excessively high mutational incidence. The process of...
Daniela Intartaglia et al.
Frontiers in cell and developmental biology, 8, 132-132 (2020-03-21)
Mucopolysaccharidosis type IIIA (MPS-IIIA, Sanfilippo A) is one of the most severe lysosomal storage disorder (LSD) caused by the inherited deficiency of sulfamidase, a lysosomal sulfatase enzyme involved in the stepwise degradation of heparan sulfates (HS). MPS-IIIA patients show multisystemic...
Z-H Cui et al.
European review for medical and pharmacological sciences, 24(1), 444-451 (2020-01-21)
To study the protective mechanism of glutamine (Gln) on myocardial ischemia-reperfusion (IR) injury in rats through the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway. A total of 30 healthy SD rats weighing 200-300 g were used in this experiment....
Yasukazu Takanezawa et al.
Biochemical and biophysical research communications, 526(1), 206-212 (2020-03-24)
Gadolinium-based contrast agents (GBCAs) are widely used in clinical magnetic resonance imaging (MRI). Free gadolinium ions (Gd3+) released from GBCAs potentially increase the risk of GBCA-related toxicity. However, the cellular responses to Gd3+ and the underlying mechanisms responsible for protection...
Xiaolong Lin et al.
Frontiers in cellular neuroscience, 13, 567-567 (2020-01-11)
Previous reports showed that 2-(-2-benzofuranyl)-2-imidazoline (2-BFI) has antioxidant, anti-inflammatory and anti-apoptotic effects on neuroprotection in numerous disorders. However, the precise mechanisms remain elusive. The nuclear factor c factor 2 (Nrf2)/antioxidant response element (ARE) signaling pathway plays an important and essential...
Hikari Tanaka et al.
Nature communications, 11(1), 507-507 (2020-01-26)
The timing and characteristics of neuronal death in Alzheimer's disease (AD) remain largely unknown. Here we examine AD mouse models with an original marker, myristoylated alanine-rich C-kinase substrate phosphorylated at serine 46 (pSer46-MARCKS), and reveal an increase of neuronal necrosis...
Qianqian Zheng et al.
Brain research bulletin, 155, 48-60 (2019-12-04)
Epilepsy is one of the most common neurological conditions. Recent findings suggest that one of the mechanisms promoting its existence is calcium influx. The transient receptor potential melastatin type 2 channel (TRPM2) is a Ca2+-permeable cation channel that contributes to...
Alessia Garufi et al.
Biomolecules, 10(3) (2020-03-07)
The unfolded protein response (UPR) is an adaptive response to intrinsic and external stressors, and it is mainly activated by the accumulation of misfolded proteins at the endoplasmic reticulum (ER) lumen producing ER stress. The UPR signaling network is interconnected...
Yuan Xiong et al.
Journal of nanobiotechnology, 18(1), 66-66 (2020-04-30)
Osteoblast differentiation is a vital process for fracture healing, and exosomes are nanosized membrane vesicles that can deliver therapeutic drugs easily and safely. Macrophages participate in the regulation of various biological processes in vivo, and macrophage-derived exosomes (MD-Exos) have recently...
Dieter Fink et al.
Cancers, 12(1) (2020-01-08)
The ING3 candidate tumour suppressor belongs to a family of histone modifying proteins involved in regulating cell proliferation, senescence, apoptosis, chromatin remodeling, and DNA repair. It is a stoichiometric member of the minimal NuA4 histone acetyl transferase (HAT) complex consisting...
Myoung-Ju Kim et al.
International journal of molecular sciences, 21(11) (2020-06-04)
Atopic dermatitis (AD) is one of the most common skin diseases with inflammation, chronic relapses, and intense pruritus. Its pathogenesis includes genetic susceptibility, an abnormal epidermal lipid barrier, and an increased production of IgE due to immune dysregulation. Recently, AD...
David E Place et al.
PLoS pathogens, 16(3), e1008364-e1008364 (2020-03-10)
Innate immunity responds to pathogens by producing alarm signals and activating pathways that make host cells inhospitable for pathogen replication. The intracellular bacterium Burkholderia thailandensis invades the cytosol, hijacks host actin, and induces cell fusion to spread to adjacent cells...
Nada Alhazmi et al.
Biochimica et biophysica acta. Molecular cell research, 1867(8), 118707-118707 (2020-04-04)
The gene encoding promyelocytic leukemia protein (PML) generates several spliced isoforms. Ectopic expression of PML1 promotes the proliferation of ERα-positive MCF-7 breast cancer (BC) cells, while a loss of PML by knockdown or overexpression of PML4 does the opposite. PML...
Xuan Wang et al.
Toxicology in vitro : an international journal published in association with BIBRA, 66, 104834-104834 (2020-03-23)
Cadmium (Cd) is a pervasive harmful metal in the environment. It is a well-known inducer of tumorigenesis, but its mechanism is still unclear. We have previously reported that Cd-induced autophagy was apoptosis-dependent and prevents apoptotic cell death to ensure the...
Sze Wing Tang et al.
Acta biomaterialia, 102, 114-126 (2019-11-23)
Cells in tissues are enveloped by an instructive niche made of the extracellular matrix. These instructive niches contain three general types of information: topographical, biochemical and mechanical. While the combined effects of these three factors are widely studied, the functions...
Page 1 of 9
Page 1 of 9