Showing 1-30 of 41 results for "K4394"
Benjamin Philmus et al.
Chembiochem : a European journal of chemical biology, 16(12), 1782-1790 (2015-06-17)
Pseudomonas spp. are prolific producers of natural products from many structural classes. Here we show that the soil bacterium Pseudomonas protegens Pf-5 is capable of producing trace levels of the triazine natural product toxoflavin (1) under microaerobic conditions. We evaluated...
Phyllis S Y Chong et al.
Oncogene, 38(9), 1508-1519 (2018-10-12)
Aberrant activation of Wnt/β-catenin signaling pathway is essential for the development of AML; however, the mechanistic basis for this dysregulation is unclear. PRL-3 is an oncogenic phosphatase implicated in the development of LSCs. Here, we identified Leo1 as a direct...
L M Lin et al.
The Analyst, 116(9), 919-922 (1991-09-01)
A linear combination derivative spectrophotometric method is described. The method overcomes the problem of overlapping in derivative spectrophotometry and allows the maximum use of quantitative information. In addition, the method can be used to increase the selectivity, sensitivity and accuracy...
Jinwoo Kim et al.
Molecular microbiology, 54(4), 921-934 (2004-11-04)
Burkholderia glumae BGR1 produces a broad-host range phytotoxin, called toxoflavin, which is a key pathogenicity factor in rice grain rot and wilt in many field crops. Our molecular and genetic analyses of toxoflavin-deficient mutants demonstrated that gene clusters for toxoflavin...
Woo-Suk Jung et al.
PloS one, 6(7), e22443-e22443 (2011-07-30)
Pathogenic bacteria synthesize and secrete toxic low molecular weight compounds as virulence factors. These microbial toxins play essential roles in the pathogenicity of bacteria in various hosts, and are emerging as targets for antivirulence strategies. Toxoflavin, a phytotoxin produced by...
S A Dovzhenko et al.
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 33(1), 30-33 (1988-01-01)
Reaction of xanthothricin demethylation by amines in acetone as a solvent yielded a new compound with a formula of C10H13N5O3. Mass spectrometry, 1H NMR-spectroscopy and x-ray analysis showed that the compound was 4H-1,6-dimethyl-4a(2-oxopropyl)-pyrimido-[5,4-e]-1 ,2,4-triazine-5,7-dione.
Boknam Jung et al.
Nature communications, 9(1), 31-31 (2018-01-04)
Bacterial-fungal interactions are widely found in distinct environments and contribute to ecosystem processes. Previous studies of these interactions have mostly been performed in soil, and only limited studies of aerial plant tissues have been conducted. Here we show that a...
Ji-Eun Choi et al.
PloS one, 13(1), e0183893-e0183893 (2018-01-03)
Toxoflavin, a 7-azapteridine phytotoxin produced by the bacterial pathogens such as Burkholderia glumae and Burkholderia gladioli, has been known as one of the key virulence factors in crop diseases. Because the toxoflavin had an antibacterial activity, a metagenomic E. coli...
Ana Paola G Lombardi et al.
Frontiers in endocrinology, 11, 184-184 (2020-04-25)
Prostate cancer is initially dependent on the androgen, gradually evolves into an androgen-independent form of the disease, also known as castration-resistant prostate cancer (CRPC). At this stage, current therapies scantily improve survival of the patient. Androgens and estrogens are involved...
G G Aleksandrov et al.
Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology, 31(3), 181-184 (1986-03-01)
The structures of xanthothricin (I) and fervenulin (II), pyrimido-[5,4-e]-1,2,4-triazine antibiotics were determined by x-ray analysis. The crystals of I and II are monoclinic: a 9.667(6), 18.270(7), b 14.029(9), 5.723(2), c 6.914(3), 18.058(7) A, beta 116.47(3), 118.90(2) degrees, Z 4,8; space...
T Nagamatsu et al.
Chemical & pharmaceutical bulletin, 41(2), 362-368 (1993-02-01)
6-Phenyl analogs of toxoflavin (1-methyl-6-phenylpyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-diones ) (7a--f) and their 4-oxides (8a-f) were synthesized by nitrosative or nitrative cyclization of the aldehyde hydrazones (6a-f) of 6-(1-methylhydrazino)-3-phenyluracil (5). Both sets of compounds, 7a-f and 8a-f, gave the corresponding 1-demethyl derivatives (10a-f) upon...
K A Buckle et al.
The Journal of applied bacteriology, 68(6), 571-576 (1990-06-01)
Tempe bongkrek was prepared from partially defatted coconut by fermentation with the mould Rhizopus oligosporus. The addition of 2% sodium chloride decreased but did not inhibit formation of bongkrek acid by Pseudomonas cocovenenans strain ITB in either coconut culture medium...
Mi-Sun Kim et al.
Bioscience, biotechnology, and biochemistry, 76(12), 2354-2356 (2012-12-12)
This study established a new system for potato transformation using toxoflavin as selection agent and toxoflavin lyase (tflA) as selectable marker gene. Potato plants expressing tflA was successfully transformed on toxoflavin medium with 27% efficiency, similar to that for the...
Michael K Fenwick et al.
Biochemistry, 50(6), 1091-1100 (2010-12-21)
High-resolution crystal structures are reported for apo, holo, and substrate-bound forms of a toxoflavin-degrading metalloenzyme (TflA). In addition, the degradation reaction is shown to be dependent on oxygen, Mn(II), and dithiothreitol in vitro. Despite its low sequence identity with proteins...
Nathan Moreau et al.
Molecular pain, 13, 1744806917727625-1744806917727625 (2017-08-18)
Blood–nerve barrier disruption is pivotal in the development of neuroinflammation, peripheral sensitization, and neuropathic pain after peripheral nerve injury. Activation of toll-like receptor 4 and inactivation of Sonic Hedgehog signaling pathways within the endoneurial endothelial cells are key events, resulting...
Ying Xie et al.
Stem cell research, 32, 51-60 (2018-09-04)
A recent paradigm shift in ovarian cancer research is the finding that many ovarian cancers may originate from fallopian tube epithelial (FTE) cells. As tissue stem and progenitor cells often serve as cells of origin of cancer, a better understanding...
J Y Park et al.
Letters in applied microbiology, 51(6), 619-624 (2010-11-03)
The primary objective of this study was to determine the effects of quorum quenching in the pathogenicity and toxoflavin production of Burkholderia glumae causing bacterial rice grain rot. An acyl-homoserine lactonase (aiiA) gene from Bacillus sp. was expressed in B....
Z Wang et al.
British journal of pharmacology, 117(2), 293-298 (1996-01-01)
1. It has been suggested that the toxic effect of toxoflavin (TXF) produced by Pseudomonas cocovenenas is mainly due to the impairment of electron transfer of the mitochondrial respiratory chain. However, the cardiovascular effect of TXF is unknown. In the...
Heejin Chun et al.
Journal of bacteriology, 191(13), 4152-4157 (2009-04-28)
Quorum sensing (QS) plays important roles in the pathogenicity of Burkholderia glumae, the causative agent of bacterial rice grain rot. We determined how QS is involved in catalase expression in B. glumae. The QS-defective mutant of B. glumae exhibited less...
Tiago Lelis et al.
Molecular plant-microbe interactions : MPMI, 32(7), 841-852 (2019-01-30)
Bacterial panicle blight caused by Burkholderia glumae is a major bacterial disease of rice. Our preliminary RNA-seq study showed that a serine metalloprotease gene, prtA, is regulated in a similar manner to the genes for the biosynthesis and transport of...
Q A Yue
Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine], 23(2), 77-79 (1989-03-01)
Fermented corn flour containing toxoflavin and bongkretic acid produced by P. farinofermentans can cause acute food poisoning, but study on mutagenicity of toxoflavin has not been reported. We studied the mutagenicity of toxoflavin by Tradescantia Paludosa and animal micronucleus tests....
Travis M Falconer et al.
Forensic science international, 270, e5-e11 (2016-11-09)
In January 2015, 75 people died and 177 were hospitalized in the Mozambique village of Chitima after attending a funeral. The deaths were linked to the consumption of a traditional African beverage called pombe. Samples of the suspect pombe were...
Giulia Devescovi et al.
Applied and environmental microbiology, 73(15), 4950-4958 (2007-06-15)
Burkholderia glumae is an emerging rice pathogen in several areas around the world. Closely related Burkholderia species are important opportunistic human pathogens for specific groups of patients, such as patients with cystic fibrosis and patients with chronic granulomatous disease. Here...
Yongsung Kang et al.
Scientific reports, 9(1), 11038-11038 (2019-08-01)
The activated methyl cycle (AMC) is responsible for the generation of S-adenosylmethionine (SAM), which is a substrate of N-acylhomoserine lactone (AHL) synthases. However, it is unknown whether AHL-mediated quorum sensing (QS) plays a role in the metabolic flux of the...
Gregory Lazarian et al.
Oncogene, 39(14), 2934-2947 (2020-02-09)
B-cell receptor (BCR) signaling pathways and interactions with the tumor microenvironment account for mantle cell lymphoma (MCL) cells survival in lymphoid organs. In several MCL cases, the WNT/β-catenin canonical pathway is activated and β-catenin accumulates into the nucleus. As both...
S E Esipov et al.
Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology, 30(2), 122-124 (1985-02-01)
A comparative study of the NMR 1H and 13C spectra of reumycin, fervenulin and xanthothricin in aqueous acid-base media showed that at pH or pD ranging from 8.0 to 1.0 the antibiotics were chemically stable. By the ratio of the...
Radosveta Gencheva et al.
Biochimica et biophysica acta. General subjects (2018-05-29)
Toxoflavin (1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dione; xanthothricin) is a well-known natural toxin of the pyrimidinetriazinedione type that redox cycles with oxygen under reducing conditions. In mammalian systems, toxoflavin is an inhibitor of Wnt signaling as well as of SIRT1 and SIRT2 activities, but other...
Xiaodan Li et al.
Applied and environmental microbiology, 85(9) (2019-03-03)
Fungal infections not only cause extensive agricultural damage but also result in serious diseases in the immunodeficient populations of human beings. Moreover, the increasing emergence of drug resistance has led to a decrease in the efficacy of current antifungals. Thus...
Ruoxi Chen et al.
PloS one, 7(12), e52150-e52150 (2013-01-04)
Burkholderia glumae causes bacterial panicle blight of rice and produces major virulence factors, including toxoflavin, under the control of the quorum-sensing (QS) system mediated by the luxI homolog, tofI, and the luxR homolog, tofR. In this study, a series of...

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