Showing 1-14 of 14 results for "kspq12012"
G R Sharath Babu et al.
Frontiers in pharmacology, 8, 868-868 (2017-12-13)
Pelargonidin chloride (PC) is one of the major anthocyanin found in berries, radish and other natural foods. Many natural chemopreventive compounds have been shown to be potent inducers of phase II detoxification genes and its up-regulation is important for oxidative...
I Osorio-Querejeta et al.
Pharmaceutics, 12(2) (2020-02-27)
Remyelination is a key aspect in multiple sclerosis pathology and a special effort is being made to promote it. However, there is still no available treatment to regenerate myelin and several strategies are being scrutinized. Myelination is naturally performed by...
Ana Paula Oliveira De Quadros et al.
Journal of toxicology and environmental health. Part A, 83(13-14), 495-508 (2020-06-23)
Sm. (Rosaceae) is a plant traditionally used in Brazil and some other countries to treat diarrhea, stomach diseases, and as an analgesic, antimicrobial, antihypertensive, and as well as other pharmacological properties. The aim of this study was to examine cytotoxic...
Aaminah Khan et al.
Nature communications, 12(1), 971-971 (2021-02-14)
Diffuse intrinsic pontine glioma (DIPG) is an incurable malignant childhood brain tumor, with no active systemic therapies and a 5-year survival of less than 1%. Polyamines are small organic polycations that are essential for DNA replication, translation and cell proliferation....
Kian F Eichholz et al.
Stem cells translational medicine, 9(11), 1431-1447 (2020-07-17)
Bone formation or regeneration requires the recruitment, proliferation, and osteogenic differentiation of stem/stromal progenitor cells. A potent stimulus driving this process is mechanical loading. Osteocytes are mechanosensitive cells that play fundamental roles in coordinating loading-induced bone formation via the secretion...
Mara Ribeiro Almeida et al.
Molecular nutrition & food research, 60(7), 1615-1624 (2016-03-05)
Vitamin B6 plays crucial roles on brain development and its maternal deficiency impacts the gamma-aminobutyric acid (GABA)ergic, serotonergic, glutamatergic, and dopaminergic systems in offspring. However, the molecular mechanisms underlying these neurological changes are not well understood. Thus, we aimed at...
Antonis C Antoniou et al.
The New England journal of medicine, 371(6), 497-506 (2014-08-08)
Germline loss-of-function mutations in PALB2 are known to confer a predisposition to breast cancer. However, the lifetime risk of breast cancer that is conferred by such mutations remains unknown. We analyzed the risk of breast cancer among 362 members of...
Agata Nyga et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 107(5), 1352-1362 (2018-09-28)
We aimed to find a biomarker for patients with adverse reaction to metal debris (ARMD) due to a metal-on-metal (MoM) hip implant. First, we compared molecular markers of hypoxia-inducible factor (HIF) pathway activation (BNIP3, GLUT1, HO1, VEGF, and HIF1A) and...
Sanjay Basak et al.
Cell biology international, 44(5), 1237-1251 (2020-02-20)
Curcumin has a protective role in placental diseases like preeclampsia and preterm birth. Very little is known about its functional effects on growth, angiogenesis, and epigenetic activities of human first trimester placenta. HTR8/SVneo trophoblasts cells were used as model for...
Sun Woong Kim et al.
The ocular surface, 16(4), 463-469 (2018-07-11)
To evaluate the role of PPARγ in regulating meibocyte differentiation and lipid synthesis in a human meibomian gland epithelial cell line (hMGEC). HMGEC were exposed to the PPARγ agonist, Rosiglitazone, from 10-50 μM. Cultures were also exposed to specific PPARγ antagonist...
Brijesh K Singh et al.
The Journal of biological chemistry, 291(1), 198-214 (2015-10-11)
MTORC2-AKT is a key regulator of carbohydrate metabolism and insulin signaling due to its effects on FOXO1 phosphorylation. Interestingly, both FOXO1 and thyroid hormone (TH) have similar effects on carbohydrate and energy metabolism as well as overlapping transcriptional regulation of...
Helen Heath et al.
The EMBO journal, 27(21), 2839-2850 (2008-10-17)
The 11-zinc finger protein CCCTC-binding factor (CTCF) is a highly conserved protein, involved in imprinting, long-range chromatin interactions and transcription. To investigate its function in vivo, we generated mice with a conditional Ctcf knockout allele. Consistent with a previous report...
Susan D'Costa et al.
The Journal of allergy and clinical immunology, 143(5), 1865-1877 (2018-11-16)
Psychological stress and heightened mast cell (MC) activation are linked with important immunologic disorders, including allergy, anaphylaxis, asthma, and functional bowel diseases, but the mechanisms remain poorly defined. We have previously demonstrated that activation of the corticotropin-releasing factor (CRF) system...
Saravanan Ayyadurai et al.
Journal of leukocyte biology, 102(6), 1299-1312 (2017-07-08)
Life stress is a major risk factor in the onset and exacerbation of mast cell-associated diseases, including allergy/anaphylaxis, asthma, and irritable bowel syndrome. Although it is known that mast cells are highly activated upon stressful events, the mechanisms by which...

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