Showing 1-30 of 215 results for "L0517"
L Iversen et al.
The Journal of investigative dermatology, 100(3), 293-298 (1993-03-01)
In the present study, keratinocytes were coincubated with human neutrophils to determine whether or not an increase in leukotriene B4 formation can occur. Human keratinocytes used were cultured in serum-free, low-calcium medium, whereas neutrophils were purified from heparinized venous blood....
W H Dokter et al.
Leukemia, 8(7), 1181-1184 (1994-07-01)
Interleukin-4 inhibits several monocyte functions like A23187-induced expression of cytokines and c-fos and c-jun proto-oncogene mRNA expression. In an attempt to elucidate the mechanism by which this inhibitive effect is mediated, we compared the effect of IL-4 on A23187-induced c-fos...
Tim Lämmermann et al.
Nature, 498(7454), 371-375 (2013-05-28)
Neutrophil recruitment from blood to extravascular sites of sterile or infectious tissue damage is a hallmark of early innate immune responses, and the molecular events leading to cell exit from the bloodstream have been well defined. Once outside the vessel...
Vincenzo Quagliariello et al.
International journal of nanomedicine, 15, 4859-4876 (2020-08-09)
CoenzymeQ10 (CoQ10) is a well-known antioxidant and anti-inflammatory agent with cardioprotective properties. However, clinical trials based on its oral administration have failed to provide significant effect on cardiac functionality. The main limitation of CoQ10 is based on its very low...
Guang-Lin Xu et al.
Toxicology and applied pharmacology, 272(1), 221-229 (2013-06-05)
KYKZL-1, a newly synthesized compound with COX/5-LOX dual inhibition, was subjected to the anti-inflammatory activity test focusing on its modulation of inflammatory mediators as well as intracellular MAPK and NF-κB signaling pathways. In acute ear edema model, pretreatment with KYKZL-1...
Stephan W Reinhold et al.
Lipids, 48(2), 167-175 (2013-01-01)
Acute transplant rejection is the leading cause of graft loss in the first months after kidney transplantation. Lipoxygenase products mediate pro- and anti-inflammatory actions and thus we aimed to correlate the histological reports of renal transplant biopsies with urinary lipoxygenase...
Sergei I Ochkur et al.
American journal of respiratory cell and molecular biology, 49(6), 1074-1084 (2013-07-19)
Leukotrienes (i.e., products of the 5-lipoxygenase pathway) are thought to be contributors to lung pathologies. Moreover, eosinophils have been linked with pulmonary leukotriene activities both as potential sources of these mediators and as responding effector cells. The objective of the...
Toru Kono et al.
Integrative cancer therapies, 13(5), 435-445 (2014-02-07)
Chemotherapy-induced oral mucositis (COM) is characterized by painful inflammation with prolonged damage that involves the pathological pain-evoking prostaglandin E2 (PGE2). We previously found that gargling with hangeshashinto (HST), a traditional Japanese medicine, was effective for the treatment of COM. However...
Guizhu Liu et al.
British journal of pharmacology, 175(8), 1205-1216 (2017-09-20)
An appropriate inflammatory response is necessary for cardiac healing after acute myocardial infarction (MI). Resolvin E1 (RvE1) is an anti-inflammatory and pro-resolution lipid mediator derived from eicosapentaenoic acid. Here we have investigated the effects of RvE1 on the recovery of...
Shotaro Uehara et al.
Biochemical pharmacology, 171, 113721-113721 (2019-11-22)
The common marmoset (Callithrix jacchus) is a New World monkey that has attracted much attention as a potentially useful primate model for preclinical testing. A total of 36 marmoset cytochrome P450 (P450) isoforms in the P450 1-51 subfamilies have been...
Akiko Toda et al.
Prostaglandins & other lipid mediators, 68-69, 575-585 (2002-11-16)
Leukotriene B4 (LTB4) is a potent chemotactic agent and activating factor for granulocytes. Two cell surface receptors for LTB4 (BLT1 and BLT2) have been isolated in the last few years. These receptors are G-protein-coupled receptors (GPCR), and they have 45%...
Yaoyu Chen et al.
Cancer research, 77(1), 164-174 (2016-10-28)
Myeloproliferative neoplasms such as polycythemia vera (PV), which are associated with the JAK mutation V617F, remain incurable despite progress in the use of JAK2 inhibitors for treatment of some of these diseases. In this study, we employed mice that undergo...
Sanja Arandjelovic et al.
Nature immunology, 20(2), 141-151 (2019-01-16)
Rheumatoid arthritis is characterized by progressive joint inflammation and affects ~1% of the human population. We noted single-nucleotide polymorphisms (SNPs) in the apoptotic cell-engulfment genes ELMO1, DOCK2, and RAC1 linked to rheumatoid arthritis. As ELMO1 promotes cytoskeletal reorganization during engulfment...
Xiu-juan Li et al.
The Journal of surgical research, 193(2), 902-908 (2014-12-03)
The controversial results from different studies suggested that leukocyte recruitment mediated by leukotriene B4 (LTB4) and its receptor might improve pathogen clearance, but might also aggravate organ injury during sepsis. The present study was performed to compare the effect of...
Naomi Oi et al.
Carcinogenesis, 38(7), 728-737 (2017-06-03)
Leukotriene A4 hydrolase (LTA4H), a bifunctional zinc metallo-enzyme, is reportedly overexpressed in several human cancers. Our group has focused on LTA4H as a potential target for cancer prevention and/or therapy. In the present study, we report that LTA4H is a...
Yue Zhao et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1104, 11-17 (2018-11-13)
Leontopodium leontopodioides (Willd.) Beauv. is used therapeutically to prevent numerous diseases. Historically, L. leontopodioides extracts have been used to treat influenza infections, bronchitis, acute and chronic nephritis, proteinuria, hematuria, and diabetes. However, the bioactive compounds that are responsible for the...
B V Ghule et al.
Journal of ethnopharmacology, 249, 112374-112374 (2019-11-11)
The aerial parts of Barleria prionitis Linn. (BP) (Acanthaceae) plant has long been used to treat inflammatory disorders such as toothache, swellings, arthritis and gout. The purpose of this study was to evaluate the effects of shanzhiside methyl ester (SME)...
Exhaled breath condensate eicosanoid levels in asthma: still questioned.
Wei-Jie Guan et al.
The Journal of allergy and clinical immunology, 133(4), 1231-1232 (2014-02-18)
John W McGinty et al.
Immunity, 52(3), 528-541 (2020-03-12)
Helminths, allergens, and certain protists induce type 2 immune responses, but the underlying mechanisms of immune activation remain poorly understood. In the small intestine, chemosensing by epithelial tuft cells results in the activation of group 2 innate lymphoid cells (ILC2s)...
Maitham Khajah et al.
Journal of immunology (Baltimore, Md. : 1950), 190(5), 2208-2216 (2013-01-29)
Neutrophil recruitment and directional movement toward chemotactic stimuli are important processes in innate immune responses. This study examines the role of Fer kinase in neutrophil recruitment and chemotaxis to various chemoattractants in vitro and in vivo. Mice targeted with a...
Julia Homann et al.
PloS one, 10(11), e0143141-e0143141 (2015-11-26)
The activation and infiltration of polymorphonuclear neutrophils (PMN) are critical key steps in inflammation. PMN-mediated inflammation is limited by anti-inflammatory and pro-resolving mechanisms, including specialized pro-resolving lipid mediators (SPM). We examined the effects of 15-epi-LXA4 on inflammation and the biosynthesis...
Alessandro Lambiase et al.
Archives of ophthalmology (Chicago, Ill. : 1960), 121(5), 615-620 (2003-05-14)
To evaluate the effects on signs and symptoms of a coexisting vernal keratoconjunctivitis in patients treated with oral montelukast sodium for asthma. Twelve patients with vernal keratoconjunctivitis and asthma were enrolled in this pilot study. Topical eyedrops or any systemic...
Elyara M Soares et al.
Journal of immunology (Baltimore, Md. : 1950), 190(4), 1614-1622 (2013-01-18)
Puerperal sepsis is a leading cause of maternal mortality worldwide. Streptococcus pyogenes [group A Streptococcus; (GAS)] is a major etiologic agent of severe postpartum sepsis, yet little is known regarding the pathogenesis of these infections. Tissue macrophages provide innate defense...
Sumner H Burstein
Bioorganic & medicinal chemistry, 27(13), 2718-2728 (2019-05-21)
Interactions between cannabinoids and eicosanoids have been observed for the last several decades and account for a variety of cannabinoid actions. These were seen both in vitro and in vivo and may provide a molecular basis for these actions. Some...
Elizabeth S Fernandes et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(4), 1664-1673 (2012-12-29)
The underlying mechanisms of itch are poorly understood. We have investigated a model involving the chemoattractant leukotriene B₄ (LTB₄) that is up-regulated in common skin diseases. Intradermal injection of LTB4 (0.1 nmol/site) into female CD1 mice induced significant scratching movements...
Premysl Landa et al.
Natural product communications, 8(1), 105-108 (2013-03-12)
Quinones are compounds frequently contained in medicinal plants used for the treatment of inflammatory diseases. Therefore, the impact of plant-derived quinones on the arachidonic acid metabolic pathway is worthy of investigation. In this study, twenty-three quinone compounds of plant origin...
[Leukotriene B4 and its receptors].
Takehiko Yokomizo
Fukuoka igaku zasshi = Hukuoka acta medica, 97(7), 183-191 (2006-10-10)
Zhou Yu et al.
Circulation research, 112(3), 432-440 (2012-12-20)
Human genetics have implicated the 5-lipoxygenase enzyme in the pathogenesis of cardiovascular disease, and an inhibitor of the 5-lipoxygenase activating protein (FLAP) is in clinical development for asthma. Here we determined whether FLAP deletion modifies the response to vascular injury....
N Murata et al.
Journal of dental research, 92(7), 641-647 (2013-05-08)
In orthodontic tooth movement (OTM), we should be concerned about external root resorption (ERR) as an undesirable iatrogenic problem, but its mechanisms are not fully understood. Since our previous epidemiologic studies found that patients with allergic diseases showed higher rates...
T Gobbetti et al.
British journal of pharmacology, 172(3), 910-923 (2014-10-10)
Long-term intake of dietary fatty acids is known to predispose to chronic inflammation, but their effects on acute intestinal ischaemia/reperfusion (I/R) injury is unknown. The aim of this study was to determine the consequences of a diet rich in n-3...

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