Showing 1-7 of 7 results for "L2045"
A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation
Zeng X, et al.
Nature, 438(7069), 873-877 (2005)
Zhihong Cheng et al.
Nature structural & molecular biology, 18(11), 1204-1210 (2011-10-11)
Low-density-lipoprotein (LDL) receptor-related proteins 5 and 6 (LRP5/6) are Wnt co-receptors essential for Wnt/β-catenin signaling. Dickkopf 1 (DKK1) inhibits Wnt signaling by interacting with the extracellular domains of LRP5/6 and is a drug target for multiple diseases. Here we present...
Adrián Mariño-Enríquez et al.
Human pathology, 39(12), 1844-1848 (2008-07-29)
Congenital mesenchymal tumors are diagnostically challenging as they are rare and may feature overlapping patterns between several benign, low-grade, and tumors of intermediate malignancy, including myofibromatosis, myofibroma/hemangiopericytoma, congenital fibrosarcoma, and inflammatory myofibroblastic tumor. Their immunophenotype is either silent or minimally...
Srinu Tumpara et al.
Frontiers in pharmacology, 11, 983-983 (2020-07-29)
Human α1-antitrypsin (AAT) is an abundant acute phase glycoprotein expressing anti-protease and immunomodulatory activities, and is used as a biopharmaceutical to treat patients with inherited AAT deficiency. The pleiotropic properties of AAT provide a rationale for using this therapy outside...
Cheng-Ji Zhou et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 24(35), 7632-7639 (2004-09-03)
Mice with mutations in the Wnt coreceptor low-density lipoprotein receptor-related protein-6 (LRP6) have a smaller and severely disorganized dorsal thalamus and lack thalamocortical projections. Using molecular markers, we showed that most dorsal thalamic and epithalamic neurons were missing, and most...
Severe defects in dorsal thalamic development in low-density lipoprotein receptor-related protein-6 mutants
Zhou C J, et al.
The Journal of Neuroscience, 24(35), 7632-7639 (2004)
LRP6 mutation in a family with early coronary disease and metabolic risk factors
Mani A, et al.
Science (New York, N.Y.), 315(5816), 1278-1282 (2007)

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