Showing 1-7 of 7 results for "l2045"
A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation
Zeng X, et al.
Nature, 438(7069), 873-877 (2005)
Zhihong Cheng et al.
Nature structural & molecular biology, 18(11), 1204-1210 (2011-10-11)
Low-density-lipoprotein (LDL) receptor-related proteins 5 and 6 (LRP5/6) are Wnt co-receptors essential for Wnt/β-catenin signaling. Dickkopf 1 (DKK1) inhibits Wnt signaling by interacting with the extracellular domains of LRP5/6 and is a drug target for multiple diseases. Here we present...
Adrián Mariño-Enríquez et al.
Human pathology, 39(12), 1844-1848 (2008-07-29)
Congenital mesenchymal tumors are diagnostically challenging as they are rare and may feature overlapping patterns between several benign, low-grade, and tumors of intermediate malignancy, including myofibromatosis, myofibroma/hemangiopericytoma, congenital fibrosarcoma, and inflammatory myofibroblastic tumor. Their immunophenotype is either silent or minimally...
Severe defects in dorsal thalamic development in low-density lipoprotein receptor-related protein-6 mutants
Zhou C J, et al.
The Journal of Neuroscience, 24(35), 7632-7639 (2004)
Srinu Tumpara et al.
Frontiers in pharmacology, 11, 983-983 (2020-07-29)
Human α1-antitrypsin (AAT) is an abundant acute phase glycoprotein expressing anti-protease and immunomodulatory activities, and is used as a biopharmaceutical to treat patients with inherited AAT deficiency. The pleiotropic properties of AAT provide a rationale for using this therapy outside...
Cheng-Ji Zhou et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 24(35), 7632-7639 (2004-09-03)
Mice with mutations in the Wnt coreceptor low-density lipoprotein receptor-related protein-6 (LRP6) have a smaller and severely disorganized dorsal thalamus and lack thalamocortical projections. Using molecular markers, we showed that most dorsal thalamic and epithalamic neurons were missing, and most...
LRP6 mutation in a family with early coronary disease and metabolic risk factors
Mani A, et al.
Science (New York, N.Y.), 315(5816), 1278-1282 (2007)

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