Showing 1-14 of 14 results for "L2420"
Beyond endocytosis: LRP function in cell migration, proliferation and vascular permeability
Lillis AP, et al.
Journal of Thrombosis and Haemostasis, 3(8), 1884-1893 (2005)
Deficits in receptor-mediated endocytosis and recycling in cells from mice with Gpr107 locus disruption
Zhou G, et al.
Journal of Cell Science, 127(18), 3916-3927 (2014)
Takahisa Kanekiyo et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(49), 19276-19283 (2013-12-07)
Alzheimer's disease (AD) is the most prevalent form of dementia in the elderly population. Accumulation, aggregation, and deposition of amyloid-β (Aβ) peptides generated through proteolytic cleavage of amyloid precursor protein (APP) are likely initiating events in the pathogenesis of AD....
Guo Ling Zhou et al.
Journal of cell science, 127(Pt 18), 3916-3927 (2014-05-23)
GPR107 is a type III integral membrane protein that was initially predicted to be a member of the family of G-protein-coupled receptors. This report shows that deletion of Gpr107 leads to an embryonic lethal phenotype that is characterized by a...
Anthony Fernandez-Castaneda et al.
The Journal of biological chemistry, 288(7), 4538-4548 (2012-12-25)
In the central nervous system (CNS), fast neuronal signals are facilitated by the oligodendrocyte-produced myelin sheath. Oligodendrocyte turnover or injury generates myelin debris that is usually promptly cleared by phagocytic cells. Failure to remove dying oligodendrocytes leads to accumulation of...
Identification of the low density lipoprotein (LDL) receptor-related protein-1 interactome in central nervous system myelin suggests a role in the clearance of necrotic cell debris
Fernandez-Castaneda A, et al.
The Journal of biological chemistry, 288(7), 4538-4548 (2013)
Inflammatory mediators promote production of shed LRP1/CD91, which regulates cell signaling and cytokine expression by macrophages
Gorovoy M, et al.
Journal of Leukocyte Biology, 88(4), 769-778 (2010)
Kazuhiro Yamamoto et al.
The Journal of biological chemistry, 289(10), 6462-6474 (2014-01-30)
Degradation of the cartilage proteoglycan aggrecan is an early event in the development of osteoarthritis, and a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4) and ADAMTS-5 are considered to be the major aggrecan-degrading enzymes. We have recently found that ADAMTS-5...
TOPBP1 recruits TOP2A to ultra-fine anaphase bridges to aid in their resolution
Broderick R, et al.
Nature Communications, 6(1), 1-12 (2015)
Yu Jerry Zhou et al.
Cancer immunology research, 2(3), 217-228 (2014-04-30)
Host antitumor adaptive immune responses are generated as a result of the body's immunosurveillance mechanisms. How the antitumor immune response is initially primed remains unclear, given that soluble tumor antigens generally are quantitatively insufficient for cross-priming and tumors generally lack...
Chikako Nakajima et al.
Development (Cambridge, England), 141(23), 4513-4525 (2014-11-08)
Low density lipoprotein receptor-related protein 1 (LRP1) is indispensable for embryonic development. Comparing different genetically engineered mouse models, we found that expression of Lrp1 is essential in the embryo proper. Loss of LRP1 leads to lethal vascular defects with lack...
Tandem malonate-based glucosides (TMGs) for membrane protein structural studies
Hussain H, et al.
Scientific reports, 7(1), 1-11 (2017)
Genome-wide Association Study Reveals Three Susceptibility Loci for Common Migraine in the General Population
Chasman D I, et al.
Nature Genetics, 43(7), 695-695 (2011)
Alexandre Chaumet et al.
Nature communications, 6, 8218-8218 (2015-09-12)
Endocytosis directs molecular cargo along three main routes: recycling to the cell surface, transport to the Golgi apparatus or degradation in endolysosomes. Pseudomonas exotoxin A (PE) is a bacterial protein that typically traffics to the Golgi and then the endoplasmic...

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