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Showing 1-14 of 14 results for "L3410" within Papers
Sandra Barbosa-da-Silva et al.
PloS one, 7(7), e39837-e39837 (2012-08-01)
Obesity is associated with low-grade chronic inflammation attributed to dysregulated production, release of cytokines and adipokines and to dysregulated glucose-insulin homeostasis and dyslipidemia. Nutritional interventions such as dieting are often accompanied by repeated bouts of weight loss and regain, a
Sami M Khan et al.
Yonsei medical journal, 53(4), 671-679 (2012-06-06)
Leptin, a peptide hormone secreted by adipocytes in proportion of the amount of energy stored in fat, plays a central role in regulating human energy homeostasis. In addition, leptin plays a significant permissive role in the physiological regulation of several
Kate Sullivan et al.
Human molecular genetics, 23(5), 1250-1259 (2013-10-29)
There is emerging evidence for reduced muscle function in children with neurofibromatosis type 1 (NF1). We have examined three murine models featuring NF1 deficiency in muscle to study the effect on muscle function as well as any underlying pathophysiology. The
Sara Becerril et al.
Nutrients, 11(9) (2019-09-11)
Leptin, the product of the ob gene, was originally described as a satiety factor, playing a crucial role in the control of body weight. Nevertheless, the wide distribution of leptin receptors in peripheral tissues supports that leptin exerts pleiotropic biological
Monserrat Olea-Flores et al.
International journal of molecular sciences, 19(11) (2018-11-09)
Leptin is an adipokine that is overexpressed in obese and overweight people. Interestingly, women with breast cancer present high levels of leptin and of its receptor ObR. Leptin plays an important role in breast cancer progression due to the biological
Clarice F Osório et al.
Acta cirurgica brasileira, 29 Suppl 3, 44-48 (2014-10-30)
The aim of this study was to evaluate the expression of leptin and its receptor in histological sections of prostate tumors, and their association with prognostic factors. A total of 532 surgical specimens from prostate cancer were studied. After histopathological
Laura Marroquí et al.
Journal of molecular endocrinology, 49(1), R9-17 (2012-03-27)
Leptin plays an important role in the control of food intake, energy expenditure, metabolism, and body weight. This hormone also has a key function in the regulation of glucose homeostasis. Although leptin acts through central and peripheral mechanisms to modulate
Aline Penna-de-Carvalho et al.
Experimental physiology, 99(12), 1663-1678 (2014-10-19)
Telmisartan has previously been used to target obesity, showing peroxisome proliferator-activated receptor (PPAR) β/δ-related effects in white adipose tissue (WAT). We sought to evaluate whether telmisartan enhances gene and protein expression of all PPAR isoforms in WAT and brown adipose
Angela K Odle et al.
Endocrinology, 155(11), 4316-4328 (2014-08-15)
Leptin is a cytokine produced by white fat cells, skeletal muscle, the placenta, and the pituitary gland among other tissues. Best known for its role in regulating appetite and energy expenditure, leptin is produced largely by and in proportion to
Angela Katherine Odle et al.
Endocrinology, 157(4), 1443-1456 (2016-02-10)
Leptin regulates food intake and energy expenditure (EE) and is produced in adipocytes, the pituitary, and several other tissues. Animals that are leptin or leptin receptor deficient have major metabolic complications, including obesity. This study tests the hypothesis that the
Weihong Pan et al.
Annals of the New York Academy of Sciences, 1264, 64-71 (2012-04-26)
Leptin, an adipocyte-derived cytokine, crosses the blood-brain barrier to act on many regions of the central nervous system (CNS). It participates in the regulation of energy balance, inflammatory processes, immune regulation, synaptic formation, memory condensation, and neurotrophic activities. This review
Leptin and Leptin Receptor are Expressed only in Clear Cells of Rat Epididymis Epithelia.
Gombar FM and da Fonte RC
International Journal of Morphology null
Paulina Żelechowska et al.
Immunologic research, 66(5), 557-566 (2018-10-01)
Leptin, the adipose tissue-derived product of the obese (ob) gene, is known to function as the hormone of energy expenditure. It has also been established that leptin regulates immune and inflammatory processes. All leptin-induced biological activities depend on binding to
Mónica Z Jenks et al.
Scientific reports, 7(1), 8232-8232 (2017-08-16)
Leptin is an adipokine produced by fat cells that regulates food consumption and metabolic activity. Sexual dimorphism in leptin and fat stores have been observed in humans and rodents with females having more leptin and greater levels of subcutaneous fat
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