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Showing 1-30 of 64 results for "L4129" within Papers
MarĆa Velasco-Estevez et al.
Glia, 68(2), 356-375 (2019-10-10)
Piezo1 is a mechanosensitive ion channel that facilitates the translation of extracellular mechanical cues to intracellular molecular signaling cascades through a process termed, mechanotransduction. In the central nervous system (CNS), mechanically gated ion channels are important regulators of neurodevelopmental processes
Tao Li et al.
Glia, 68(6), 1201-1212 (2019-12-24)
As the most abundant gap junction protein in the central nervous system (CNS), astrocytic connexin 43 (Cx43) maintains astrocyte network homeostasis, affects oligodendroglial development and participates in CNS pathologies as well as injury progression. However, its role in remyelination is
Liang Bao et al.
Biochemical and biophysical research communications, 503(3), 1911-1918 (2018-08-02)
Lysophosphatidylcholine (LPC) is a bioactive lipid constituent of oxidized low density lipoprotein (ox-LDL). It regulates various cellular functions, including migration of circulating monocytes, expression of endothelial adhesion molecules, proliferation and migration of vascular smooth muscle cells (VSMCs). LPC can also
Elisa Giorgetti et al.
Scientific reports, 9(1), 13508-13508 (2019-09-20)
Assessment of myelin integrity in peripheral nerve injuries and pathologies has largely been limited to post-mortem analysis owing to the difficulty in obtaining biopsies without affecting nerve function. This is further encumberedĀ by the small size of the tissue and
Monique Marylin Alves de Almeida et al.
Pharmacological research, 159, 104997-104997 (2020-06-14)
Myelin loss is the hallmark of the demyelinating disease multiple sclerosis (MS) and plays a significant role in multiple neurodegenerative diseases. A common factor in all neuropathologies is the central role of microglia, the intrinsic immune cells of the central
Emily L Fishman et al.
Nature communications, 9(1), 2210-2210 (2018-06-09)
The inheritance of the centrosome during human fertilization remains mysterious. Here we show that the sperm centrosome contains, in addition to the known typical barrel-shaped centriole (the proximal centriole, PC), a surrounding matrix (pericentriolar material, PCM), and an atypical centriole
Cayce E Dorrier et al.
Nature neuroscience, 24(2), 234-244 (2021-02-03)
Fibrosis is a common pathological response to inflammation in many peripheral tissues and can prevent tissue regeneration and repair. Here, we identified persistent fibrotic scarring in the CNS following immune cell infiltration in the experimental autoimmune encephalomyelitis (EAE) mouse model
Transcription sites are developmentally regulated during the asexual cycle of Plasmodium falciparum.
Carolina B Moraes et al.
PloS one, 8(2), e55539-e55539 (2013-02-15)
Increasing evidence shows that the spatial organization of transcription is an important epigenetic factor in eukaryotic gene regulation. The malaria parasite Plasmodium falciparum shows a remarkably complex pattern of gene expression during the erythrocytic cycle, paradoxically contrasting with the relatively
Nootan Pandey et al.
The Journal of cell biology, 219(1) (2019-11-13)
Topoisomerase II (Topo II) is essential for mitosis since it resolves sister chromatid catenations. Topo II dysfunction promotes aneuploidy and drives cancer. To protect from aneuploidy, cells possess mechanisms to delay anaphase onset when Topo II is perturbed, providing additional
Lauren E McLane et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(31), 7534-7546 (2017-07-12)
Although the mammalian target of rapamycin (mTOR) is an essential regulator of developmental oligodendrocyte differentiation and myelination, oligodendrocyte-specific deletion of tuberous sclerosis complex (TSC), a major upstream inhibitor of mTOR, surprisingly also leads to hypomyelination during CNS development. However, the
S Kumar et al.
Leukemia, 19(8), 1466-1470 (2005-06-17)
Multiple myeloma (MM) is characterized by accumulation of clonal plasma cells (PCs). CD45, a key regulator of antigen-mediated signaling and activation in lymphocytes, is present in early stages of PCs development. We studied CD45 expression on MM PCs by flow
Director configurations in nematic droplets with inhomogeneous boundary conditions
Prishchepa OO, et al.
Physical review. E, 72(3), 031712-031712 (2005)
Fan Wang et al.
Frontiers in cellular neuroscience, 15, 768059-768059 (2021-11-09)
Microglia dynamically monitor the microenvironment of the central nervous system (CNS) by constantly extending and retracting their processes in physiological conditions, and microglia/macrophages rapidly migrate into lesion sites in response to injuries or diseases in the CNS. Consequently, their migration
Alan Brito Carneiro et al.
PloS one, 8(9), e76233-e76233 (2013-12-07)
Lysophosphatidylcholine (LPC) is the main phospholipid component of oxidized low-density lipoprotein (oxLDL) and is usually noted as a marker of several human diseases, such as atherosclerosis, cancer and diabetes. Some studies suggest that oxLDL modulates Toll-like receptor (TLR) signaling. However
Bryna L Fitzgerald et al.
Journal of proteome research, 19(2), 610-623 (2019-12-11)
Lyme disease is a tick-borne bacterial illness that occurs in areas of North America, Europe, and Asia. Early infection typically presents as generalized symptoms with an erythema migrans (EM) skin lesion. Dissemination of the pathogen Borrelia burgdorferi can result in
Rabia R Khawaja et al.
Cell reports, 35(7), 109147-109147 (2021-05-20)
Oligodendrocyte precursor cells (OPCs) are essential for developmental myelination and oligodendrocyte regeneration after CNS injury. These progenitors express calcium-permeable AMPA receptors (AMPARs) and form direct synapses with neurons throughout the CNS, but the roles of this signaling are unclear. To
Hyesook Yoon et al.
PloS one, 12(7), e0180697-e0180697 (2017-07-13)
Astrocytes have emerged as essential regulators of function and response to injury in the brain and spinal cord, yet very little is known about regional differences that exist. Here we compare the expression of key astroglial markers (glial fibrillary acidic
Alexandra McCarron et al.
Frontiers in pharmacology, 12, 669635-669635 (2021-05-14)
The lungs have evolved complex physical, biological and immunological defences to prevent foreign material from entering the airway epithelial cells. These mechanisms can also affect both viral and non-viral gene transfer agents, and significantly diminish the effectiveness of airway gene-addition
Liang Huang et al.
Molecular and cellular biology, 31(16), 3472-3484 (2011-06-22)
Transcriptional silencing selectively impedes gene expression. Silencing is often accompanied by replication delay and can be prevented by replicator sequences. Here we report a replicator-binding protein complex involved in the prevention of transcriptional silencing. The protein complex interacts with an
MagalĆ Barchuk et al.
Lipids, 53(10), 993-1003 (2018-12-29)
Lipoprotein lipase (LPL) and endothelial lipase (EL) are involved in lipoprotein metabolism. In insulin-resistance, their behavior is altered. Peroxisome proliferator-activated receptors (PPAR) and apoproteins (apo)CII and CIII could be partly responsible for these alterations. To evaluate this response, we assessed
Adam J Pritchard et al.
PloS one, 9(6), e99444-e99444 (2014-06-10)
The family of sphingosine-1-phosphate receptors (S1PRs) is G-protein-coupled, comprised of subtypes S1PR1-S1PR5 and activated by the endogenous ligand S1P. The phosphorylated version of Fingolimod (pFTY720), an oral therapy for multiple sclerosis (MS), induces S1PR1 internalisation in T cells, subsequent insensitivity
Ander Egimendia et al.
Pharmaceutics, 13(7) (2021-07-03)
Ex vivo models for the noninvasive study of myelin-related diseases represent an essential tool to understand the mechanisms of diseases and develop therapies against them. Herein, we assessed the potential of multimodal imaging traceable myelin-targeting liposomes to quantify myelin in
Oliver Murch et al.
British journal of pharmacology, 148(6), 769-777 (2006-06-06)
1. Lysophosphatidylcholine (LPC) modulates the inflammatory response and reduces mortality in animal models of sepsis. Here, we investigate the effects of LPC from synthetic (sLPC) and natural, soy bean derived LPC, (nLPC) sources on the organ injury/dysfunction caused by systemic
Suihong Huang et al.
Cell reports, 33(7), 108394-108394 (2020-11-19)
Circadian clocks are endogenous oscillators that generate cell-autonomous rhythms that govern cellular processes and are synchronized by external cues in the local macro- and micro-environments. Demyelination, a common brain pathology with variable degrees of recovery, changes the microenvironment via damaged
Suihong Huang et al.
STAR protocols, 2(2), 100416-100416 (2021-04-20)
This protocol combines a protective cutting method to prepare various brain slices from adult mice and real-time monitoring of circadian oscillations to measure circadian rhythmicity in various brain slices. This protocol can be applied to studies of how brain damages
Keishi Shintomi et al.
Nature communications, 12(1), 2917-2917 (2021-05-20)
Topoisomerase II (topo II) is one of the six proteins essential for mitotic chromatid reconstitution in vitro. It is not fully understood, however, mechanistically how this enzyme regulates this process. In an attempt to further refine the reconstitution assay, we
Patricia Cmielewski et al.
Respiratory research, 11, 84-84 (2010-06-24)
Poor gene transfer efficiency has been a major problem in developing an effective gene therapy for cystic fibrosis (CF) airway disease. Lysophosphatidylcholine (LPC), a natural airway surfactant, can enhance viral gene transfer in animal models. We examined the electrophysiological and
Reiji Yamazaki et al.
Journal of neurochemistry, 156(6), 917-928 (2020-08-05)
Multiple sclerosis is a chronic inflammatory demyelinating disease of the central nervous system (CNS), characterized by accumulated motor disability. However, whether remyelination promotes motor recovery following demyelinating injury remains unclear. Damage to the internal capsule (IC) is known to result
Yan Fu et al.
Journal of neuroscience research, 85(13), 2870-2881 (2007-06-07)
Coherent anti-Stokes Raman scattering (CARS) microscopy, which allows vibrational imaging of myelin sheath in its natural state, was applied to characterize lysophosphatidylcholine (lyso-PtdCho)-induced myelin degradation in tissues and in vivo. After the injection of lyso-PtdCho into ex vivo spinal tissues
Nigel Farrow et al.
Human gene therapy, 29(6), 653-662 (2017-11-29)
Cystic fibrosis (CF) lung disease is an ideal candidate for a genetic therapy. It has been shown previously that preconditioning with lysophosphatidylcholine (LPC) prior to lentiviral (LV) vector delivery results in long-term in vivo gene expression in the airway epithelium
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