Showing 1-30 of 6394 results for "L4390"
R Novaković et al.
Molecular human reproduction, 21(6), 545-551 (2015-03-10)
The ideal agent for prevention and treatment of uterine abnormal contractility has not been found. The polyphenol resveratrol possesses a wide spectrum of pharmacologic properties, but its influence on the contractility of human myometrium is not defined. The present study...
Yasuaki Wada et al.
Journal of agricultural and food chemistry, 63(30), 6787-6798 (2015-07-15)
Heat treatments are applied to milk and dairy products to ensure their microbiological safety and shelf lives. Types of heating processes may have different effects on protein modifications, leading to different protein digestibility. In this study, milk-based liquid nutritional formulas...
Sun Woo Jang et al.
International journal of pharmaceutics, 473(1-2), 187-193 (2014-07-09)
The aim of this study was to improve the physicochemical properties and oral absorption of poorly water-soluble everolimus via preparation of a solid dispersion (SD) system using a solvent wetting (SW) technique. The physicochemical properties, drug release profile, and bioavailability...
Sri N Batchu et al.
American journal of physiology. Heart and circulatory physiology, 309(6), H1048-H1058 (2015-08-16)
The pathophysiological mechanisms of the immune activation of smooth muscle cells are not well understood. Increased expression of Axl, a receptor tyrosine kinase, was recently found in arteries from patients after coronary bypass grafts. In the present study, we hypothesized...
Min-Yu Chung et al.
Journal of medicinal food, 18(11), 1198-1206 (2015-04-04)
A number of compounds isolated from mushrooms have exhibited disease-modifying effects. We sought to investigate the mechanisms responsible for the anti-inflammatory effects of an extract from the mushroom species Sarcodon asparatus (SAE). Male BALB/c mice (N=42; 6 weeks old) were...
Sailau Abeldenov et al.
DNA repair, 33, 1-16 (2015-06-05)
Apurinic/apyrimidinic (AP) endonucleases are key enzymes involved in the repair of abasic sites and DNA strand breaks. Pathogenic bacteria Mycobacterium tuberculosis contains two AP endonucleases: MtbXthA and MtbNfo members of the exonuclease III and endonuclease IV families, which are exemplified...
Tertia D Purves-Tyson et al.
Schizophrenia research, 168(3), 661-670 (2015-06-20)
Late adolescence in males is a period of increased susceptibility for the onset of schizophrenia, coinciding with increased circulating testosterone. The cognitive deficits prevalent in schizophrenia may be related to unhealthy cortical interneurons, which are trophically dependent on brain derived...
Yoshiaki Yamamoto et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(21), 4845-4855 (2015-06-25)
Lipid nanoparticle (LNP) formulations facilitate tumor uptake and intracellular processing through an enhanced permeation and retention effect (EPR), and currently multiple products are undergoing clinical evaluation. Clusterin (CLU) is a cytoprotective chaperone induced by androgen receptor (AR) pathway inhibition to...
Bingxiang Wang et al.
Journal of molecular and cellular cardiology, 82, 22-32 (2015-03-05)
Calcium-activated chloride channels (CaCCs) have been implicated in hypertension; however, the mechanism underlying their involvement is unknown. The aim of this study was to determine whether the CaCC ANO1 is involved in the pathogenesis of spontaneous hypertension. Arterial ANO1 expression...
Hongjun Wang et al.
Oncology reports, 34(3), 1503-1509 (2015-07-15)
In the present study, in order to analyze abnormalities in DNA methylation in glioma, we utilized a large cohort methylation microarray (119 glioma samples). Genes associated with tumor grade progression were screened through Significance Analysis of Microarrays (SAM) in the methylation...
Hyun Myung Ko et al.
Archives of pharmacal research, 38(4), 556-565 (2014-07-18)
Propofol, a widely used anesthetic, regulates neurological processes including neurotoxicity, neuroprotection, glial activation, synaptic plasticity and neuronal maturation. Tissue plasminogen activator/tissue plasminogen activator inhibitor-1 (tPA/PAI-1) in CNS acts as a neuromodulator regulating synaptic plasticity, neurite outgrowth, seizure spreading and cell...
Kirsty A McFarland et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(27), 8433-8438 (2015-06-24)
In mammalian cells, programmed cell death (PCD) plays important roles in development, in the removal of damaged cells, and in fighting bacterial infections. Although widespread among multicellular organisms, there are relatively few documented instances of PCD in bacteria. Here we...
Yang Xu et al.
PloS one, 9(9), e108914-e108914 (2014-10-03)
Acute respiratory distress syndrome (ARDS) is a severe and life-threatening acute lung injury (ALI) that is caused by noxious stimuli and pathogens. ALI is characterized by marked acute inflammation with elevated alveolar cytokine levels. Mitogen-activated protein kinase (MAPK) pathways are...
Si Min Zhang et al.
PloS one, 10(7), e0134851-e0134851 (2015-08-01)
The membrane proximal external region (MPER) is a highly conserved membrane-active region located at the juxtamembrane positions within class I viral fusion glycoproteins and essential for membrane fusion events during viral entry. The MPER in the human immunodeficiency virus type...
Yibing Ruan et al.
Neuro-oncology, 17(6), 822-831 (2014-11-15)
Neurocutaneous melanocytosis (NCM) is a rare congenital disorder that presents with pigmented cell lesions of the brain or leptomeninges in children with large or multiple congenital melanocytic nevi. Although the exact pathological processes involved are currently unclear, NCM appears to...
Azusa Tanimoto et al.
Oncotarget, 5(13), 4920-4928 (2014-06-24)
Alectinib is a new generation ALK inhibitor with activity against the gatekeeper L1196M mutation that showed remarkable activity in a phase I/II study with echinoderm microtubule associated protein-like 4 (EML4)--anaplastic lymphoma kinase (ALK) non-small cell lung cancer (NSCLC) patients. However...
Ling Liu et al.
PloS one, 10(7), e0133692-e0133692 (2015-07-30)
Intestinal ischemia-reperfusion has been taken as an important pathophysiological process for multiple organ dysfunctions in critical patients. Recent studies reported that dual expression programs of the B cells receptors and Toll-like receptors on B-lymphocytes permit these ubiquitous cells to integrate...
Nádia Vidal et al.
Food chemistry, 180, 288-294 (2015-03-15)
Genetically modified foods are a major concern around the world due to the lack of information concerning their safety and health effects. This work evaluates differences, at the proteomic level, between two types of crop samples: transgenic (MON810 event with...
Elizabeth Emma Palmer et al.
Molecular genetics and metabolism, 116(3), 178-186 (2015-09-01)
Asparagine Synthetase Deficiency is a recently described cause of profound intellectual disability, marked progressive cerebral atrophy and variable seizure disorder. To date there has been limited functional data explaining the underlying pathophysiology. We report a new case with compound heterozygous...
Jenny Y Y Ooi et al.
Epigenetics, 10(5), 418-430 (2015-05-06)
Pharmacological histone deacetylase (HDAC) inhibitors attenuate pathological cardiac remodeling and hypertrophic gene expression; yet, the direct histone targets remain poorly characterized. Since the inhibition of HDAC activity is associated with suppressing hypertrophy, we hypothesized histone acetylation would target genes implicated...
Yongguo Shi et al.
PloS one, 10(4), e0122679-e0122679 (2015-05-01)
BRAF activated non-coding RNA (BANCR), a long non-coding RNA (lncRNA), is crucial for cell migration in melanoma cells and non-small cell lung cancer (NSCLC) cells. However, little is known regarding the role of this gene in the proliferation of colorectal...
Gisele Espinha et al.
Molecular and cellular biochemistry, 404(1-2), 281-297 (2015-03-12)
Rac1 GTPase controls essential cellular functions related to the cytoskeleton, such as motility and adhesion. Rac1 is overexpressed in many tumor cells, including breast cancers, where it is also involved in the proliferation and checkpoint control necessary for the cell's...
E D Son et al.
Clinical and experimental dermatology, 40(3), 247-253 (2014-12-17)
Maintenance of water balance in the stratum corneum (SC) is determined by the content of intercellular lipids and natural moisturizing factors (NMFs) in corneocytes. To investigate the association between the NMFs and (pro)filaggrin and the proteases responsible for the processing...
Alicia R Feagins et al.
Journal of virology, 88(24), 14440-14450 (2014-10-10)
The Marburg virus VP40 protein is a viral matrix protein that spontaneously buds from cells. It also functions as an interferon (IFN) signaling antagonist by targeting Janus kinase 1 (JAK1). A previous study demonstrated that the VP40 protein of the...
John T Wilson et al.
The AAPS journal, 17(2), 358-369 (2014-12-17)
Protein-based vaccines offer a number of important advantages over organism-based vaccines but generally elicit poor CD8(+) T cell responses. We have previously demonstrated that pH-responsive, endosomolytic polymers can enhance protein antigen delivery to major histocompatibility complex class I (MHC-I) antigen...
Junwen Zheng et al.
Virologica Sinica, 30(3), 190-199 (2015-07-01)
HEp-2 cells persistently infected with respiratory syncytial virus (RSV) are a heterogeneous mixture of viral antigen-positive and -negative variants; however, the mechanism through which viral replication becomes latent remains unclear. In this study, we investigated the potential mechanism by which...
Dmitry Kryndushkin et al.
The Journal of biological chemistry, 288(38), 27100-27111 (2013-08-09)
The formation of amyloid aggregates is implicated both as a primary cause of cellular degeneration in multiple human diseases and as a functional mechanism for providing extraordinary strength to large protein assemblies. The recent identification and characterization of several amyloid...
Brajendra K Tripathi et al.
The Journal of cell biology, 207(5), 627-642 (2014-12-03)
DLC1 is a tumor suppressor protein whose full activity depends on its presence at focal adhesions, its Rho-GTPase activating protein (Rho-GAP) function, and its ability to bind several ligands, including tensin and talin. However, the mechanisms that regulate and coordinate...
Daniel C Teasley et al.
The Journal of biological chemistry, 290(24), 15133-15145 (2015-04-30)
The existence of redundant replication and repair systems that ensure genome stability underscores the importance of faithful DNA replication. Nowhere is this complexity more evident than in challenging DNA templates, including highly repetitive or transcribed sequences. Here, we demonstrate that...
Shan Chen et al.
Journal of medical virology, 88(1), 109-114 (2015-06-25)
Interferon-inducible protein 6-16 (IFI-6-16, ISG16) is one of the interferon stimulated genes (ISGs) whose expression levels can be induced by type I interferons. Previous studies from our group indicated that higher expression levels of ISG16 were detected in the pre-treatment...

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