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Laura Girardet et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(6), 7593-7609 (2020-04-14)
Primary cilia (PC) are organelles that sense and respond to dynamic changes of the extracellular milieu through the regulation of target genes. By using the epididymis as a model system, we determined the contribution of primary cilia in the regulation
Mohamed Lamkanfi et al.
The Journal of cell biology, 187(1), 61-70 (2009-10-07)
Inflammasomes activate caspase-1 for processing and secretion of the cytokines interleukin-1beta (IL-1beta) and IL-18. Cryopyrin/NALP3/NLRP3 is an essential component of inflammasomes triggered by microbial ligands, danger-associated molecular patterns (DAMPs), and crystals. Inappropriate Cryopyrin activity has been incriminated in the pathogenesis
Lauren M Browning et al.
Cell reports, 33(1), 108219-108219 (2020-10-08)
Bone morphogenic proteins (BMPs) are members of the transforming growth factor β (TGF-β) cytokine family promoting differentiation, homeostasis, and self-renewal of multiple tissues. We show that signaling through the bone morphogenic protein receptor 1α (BMPR1α) sustains expression of FOXP3 in
Stoyan Dimitrov et al.
Brain, behavior, and immunity, 47, 201-210 (2014-12-17)
Tumor necrosis factor (TNF) is considered a key molecule in the regulation of sleep in health and disease. Conversely, sleep compared to sleep deprivation can modulate TNF release, but overall results are conflicting. In this study we focused on the
Jui-Hu Shih et al.
Marine drugs, 18(10) (2020-10-03)
Hp-s1 ganglioside is isolated from the sperm of sea urchin (Hemicentrotus pulcherrimus). In addition to neuritogenic activity, the biological function of Hp-s1 in neuroinflammation is unknown. In this study, we investigated the anti-neuroinflammatory effect of Hp-s1 on lipopolysaccharide (LPS)-stimulated microglial
Matthew H Forsberg et al.
Stem cell research & therapy, 12(1), 459-459 (2021-08-20)
Acute radiation syndrome (ARS) is caused by acute exposure to ionizing radiation that damages multiple organ systems but especially the bone marrow (BM). We have previously shown that human macrophages educated with exosomes from human BM-derived mesenchymal stromal cells (MSCs)
Sandra Hoegl et al.
Journal of immunology (Baltimore, Md. : 1950), 195(4), 1815-1824 (2015-07-19)
Acute lung injury (ALI) is an acute inflammatory lung disease that causes morbidity and mortality in critically ill patients. However, there are many instances where ALI resolves spontaneously through endogenous pathways that help to control excessive lung inflammation. Previous studies
Ankita K Shukla et al.
Glia, 67(5), 844-856 (2018-12-28)
Alzheimer's disease (AD) is the leading cause of age-related neurodegeneration and is characterized neuropathologically by the accumulation of insoluble beta-amyloid (Aβ) peptides. In AD brains, plaque-associated myeloid (PAM) cells cluster around Aβ plaques but fail to effectively clear Aβ by
Xin Wang et al.
International journal of nanomedicine, 15, 3483-3496 (2020-06-12)
The use of polycaprolactone (PCL) for bone defects in a clinical setting is limited due to a lack of bioactivity. Exosomes derived from mesenchymal stem cells (MSCs) have an important immunoregulatory potential and together with S-nitrosoglutathione (GSNO) they possess therapeutic
Xue Jia et al.
Journal of hazardous materials, 399, 123034-123034 (2020-06-17)
Hepatic insulin resistance (IR) is the key event for arsenic-caused type 2 diabetes (T2D). However, the unequivocal mechanism of arsenic-induced hepatic IR remains unclear. The current study determined the role of NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation
Daniel Baumann et al.
Journal for immunotherapy of cancer, 9(7) (2021-07-22)
M2 macrophages promote tumor progression and therapy resistance, whereas proimmunogenic M1 macrophages can contribute to the efficacy of cytostatic and immunotherapeutic strategies. The abundance of M2 macrophages in the immune infiltrate of many cancer types has prompted the search for
Bojana Jakic et al.
Cell death & disease, 12(2), 187-187 (2021-02-17)
Memory formation is a hallmark of T cell-mediated immunity, but how differentiation into either short-lived effector cells (SLECs, CD127-KLRG1+) or memory precursors cells (MPECs, CD127+KLRG1-) and subsequent regulation of long-term memory is adjusted is incompletely understood. Here, we show that
Hernandez Moura Silva et al.
The Journal of experimental medicine, 216(4), 786-806 (2019-03-14)
Tissue-resident macrophages are the most abundant immune cell population in healthy adipose tissue. Adipose tissue macrophages (ATMs) change during metabolic stress and are thought to contribute to metabolic syndrome. Here, we studied ATM subpopulations in steady state and in response
Juan Wei et al.
Biochemical and biophysical research communications, 500(3), 790-796 (2018-04-24)
The transcription factor nuclear factor E2-related factor 2 (Nrf2) is known to control the expression of antioxidant response elements and cytoprotective genes and modulate inflammatory response, helping to ameliorate damage in many diseases. Exactly how Nrf2 regulates innate inflammatory homeostasis
Expression of high mobility group box 1 in inflamed dental pulp and its chemotactic effect on dental pulp cells.
Zhang X, Jiang H, Gong Q, et al.
Biochemical and Biophysical Research Communications, 450(4), 1547-1552 (2014)
Sheng Xiao et al.
Cell reports, 32(2), 107892-107892 (2020-07-16)
Tim-1, a phosphatidylserine receptor expressed on B cells, induces interleukin 10 (IL-10) production by sensing apoptotic cells. Here we show that mice with B cell-specific Tim-1 deletion develop tissue inflammation in multiple organs including spontaneous paralysis with inflammation in the
B Feiner et al.
Clinical and experimental immunology, 196(1), 67-75 (2019-02-05)
Epigenetic effects of anti-psychotic medications are poorly understood. We have appropriated a model whereby heterochromatin is established through 24- or 48-h lipopolysaccharide (LPS) treatment, and tested the epigenetic effects of risperidone along the adenylyl cyclase/protein kinase A (AC/PKA) pathway in
Trevor P Fidler et al.
Nature, 592(7853), 296-301 (2021-03-19)
Clonal haematopoiesis, which is highly prevalent in older individuals, arises from somatic mutations that endow a proliferative advantage to haematopoietic cells. Clonal haematopoiesis increases the risk of myocardial infarction and stroke independently of traditional risk factors1. Among the common genetic
Katerina Spyridopoulou et al.
Cancers, 13(21) (2021-11-14)
Colorectal cancer is a health problem with high mortality rates and prevalence. Thus, innovative treatment approaches need to be developed. Biogenic nanoparticles are nanomaterials that can be synthesised in biological systems and, compared to chemically synthesised nanoparticles, have better bioavailability
Guoying Zhang et al.
Journal of immunology (Baltimore, Md. : 1950), 182(12), 7997-8004 (2009-06-06)
Bacterial LPS induces rapid thrombocytopenia, hypotension, and sepsis. Although growing evidence suggests that platelet activation plays a critical role in LPS-induced thrombocytopenia and tissue damage, the mechanism of LPS-mediated platelet activation is unclear. In this study, we show that LPS
Xiaofeng Cai et al.
Journal of thrombosis and haemostasis : JTH, 17(5), 803-817 (2019-03-14)
Essentials APC elicits cytoprotective responses in endothelial cells via EPCR-dependent cleavage of PAR1. APC inhibits LPS-mediated translocation and extracellular secretion of HMGB1 in endothelial cells. Signaling activity of APC inhibits LPS-mediated acetylation of HMGB1 by epigenetic mechanisms. APC inhibits LPS-mediated
Justin H Fransen et al.
Arthritis and rheumatism, 60(8), 2304-2313 (2009-08-01)
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the formation of antinuclear autoantibodies. Increased apoptosis and reduced clearance of apoptotic material have been assigned a role in the pathogenesis of SLE, but the underlying mechanisms remain elusive. During
Amal Hasan et al.
International journal of molecular sciences, 20(17) (2019-08-25)
Elevated levels of IL-8 (CXCL8) in obesity have been linked with insulin resistance and type 2 diabetes (T2D). The mechanisms that lead to the profound production of IL-8 in obesity remains to be understood. TNF-α and saturated free fatty acids
Chuan Yan et al.
Journal of hepatology, 63(2), 420-428 (2015-04-02)
Chronic inflammation is a major etiological factor for hepatocellular carcinoma (HCC), but how immune cells respond in the initiation of hepatocarcinogenesis remains uncharacterized. This study aims to investigate the response and roles of neutrophils in early hepatocarcinogenesis. By inducible expression
Miri Shnayder et al.
eLife, 9 (2020-01-23)
Human cytomegalovirus (HCMV) causes a lifelong infection through establishment of latency. Although reactivation from latency can cause life-threatening disease, our molecular understanding of HCMV latency is incomplete. Here we use single cell RNA-seq analysis to characterize latency in monocytes and
Tim Rahmel et al.
Scientific reports, 10(1), 21029-21029 (2020-12-05)
Sepsis is characterized by a dysregulated immune response, metabolic derangements and bioenergetic failure. These alterations are closely associated with a profound and persisting mitochondrial dysfunction. This however occurs despite increased expression of the nuclear-encoded transcription factor A (TFAM) that normally
Maria Dudau et al.
Frontiers in pharmacology, 12, 737571-737571 (2021-10-30)
In recent years, natural product's research gained momentum, fueled by technological advancement and open availability of research data. To date, sea buckthorn (Hippophae rhamnoides L. [Elaeagnaceae]) plant parts, especially berries, are well characterized and repeatedly tested for antioxidant activity and
Ana S Leal et al.
Scientific reports, 9(1), 7072-7072 (2019-05-10)
The stromal reaction in pancreatic cancer creates a physical barrier that blocks therapeutic intervention and creates an immunosuppressive tumor microenvironment. The Rho/myocardin-related transcription factor (MRTF) pathway is implicated in the hyper-activation of fibroblasts in fibrotic diseases and the activation of
Anirudh Saraswathula et al.
Cancer immunology, immunotherapy : CII, 65(2), 205-211 (2016-01-14)
Regulatory B cells that secrete IL-10 (IL-10(+) Bregs) represent a suppressive subset of the B cell compartment with prominent anti-inflammatory capacity, capable of suppressing cellular and humoral responses to cancer and vaccines. B lymphocyte stimulator (BLyS) is a key regulatory
Haiping Lu et al.
Frontiers in chemistry, 9, 699802-699802 (2021-08-20)
Background: As a wound dressing and barrier membrane, surface modification of polycaprolactone (PCL) is needed in order to achieve better biological activities. Exosomes derived from mesenchymal stem cells (MSCs) hold significant tissue regeneration promise. Silver nanoparticles (Ag) have been suggested
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