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Florian E Kiene et al.
Journal of pharmaceutical and biomedical analysis, 110, 20-26 (2015-03-24)
Pharmaceutical excipients containing volatile odor-active molecules can be used in pharmaceutical development to increase patients' compliance. However, capturing the molecular composition of these odor-active substances is challenging. Therefore, guidance for the analytical investigation of these excipients should be developed. Using
Anna Vallverdú-Queralt et al.
International journal of molecular sciences, 16(5), 9588-9599 (2015-05-01)
The consumption of carotenoid-rich vegetables such as tomatoes and tomato sauces is associated with reduced risk of several chronic diseases. The predominant carotenoids in tomato products are in the (all-E) configuration, but (Z) isomers can be formed during thermal processing.
Taifeng Zhou et al.
eLife, 9 (2020-03-19)
Mechanical forces are fundamental regulators of cell behaviors. However, molecular regulation of mechanotransduction remain poorly understood. Here, we identified the mechanosensitive channels Piezo1 and Piezo2 as key force sensors required for bone development and osteoblast differentiation. Loss of Piezo1, or
Timothy R Powell et al.
International journal of methods in psychiatric research, 23(2), 279-288 (2014-03-29)
Recent studies have revealed that antidepressants affect the expression of constitutively expressed "housekeeping genes" commonly used as normalizing reference genes in quantitative polymerase chain reaction (qPCR) experiments. There has yet to be an investigation however on the effects of mood-stabilizers
Kelly J Clemens et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 39(11), 2584-2593 (2014-05-16)
Tobacco addiction involves a transition from occasional, voluntary smoking towards habitual behavior that becomes increasingly resistant to quitting. The development of smoking habits may reflect a loss of behavioral control that can be modeled in rats. This study investigated the
Andreas Holzinger et al.
Planta, 242(2), 477-492 (2015-04-22)
Desiccation leads to structural changes of the inner pectic cell wall layers in Ulva compressa. This contributes to protection against mechanical damage due to desiccation-rehydration cycles. Ulva compressa, characterized by rbcL phylogeny, is a common species in the Mediterranean Sea.
Matthew E Carter et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(11), 4582-4586 (2015-03-20)
Conditioned taste aversion (CTA) is a phenomenon in which an individual forms an association between a novel tastant and toxin-induced gastrointestinal malaise. Previous studies showed that the parabrachial nucleus (PBN) contains neurons that are necessary for the acquisition of CTA
Maria Cecília D Costa et al.
Planta, 242(2), 435-449 (2015-03-27)
During re-establishment of desiccation tolerance (DT), early events promote initial protection and growth arrest, while late events promote stress adaptation and contribute to survival in the dry state. Mature seeds of Arabidopsis thaliana are desiccation tolerant, but they lose desiccation
Nonkululeko B Magagula et al.
Journal of medical virology, 87(1), 79-101 (2014-05-21)
Group A rotaviruses (RVAs) are the leading cause of severe gastroenteritis and eventually death among infants and young children worldwide, and disease prevention and management through vaccination is a public health priority. In August 2009, Rotarix™ was introduced in the
Clare L Thompson et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 33(10), 1552-1559 (2015-07-16)
Osteoarthritis is a chronic degenerative disease that affects the articular cartilage. Recent studies have demonstrated that lithium chloride exhibits significant efficacy as a chondroprotective agent, blocking cartilage degradation in response to inflammatory cytokines. However, conflicting literature suggests lithium may affect
Lei Huang et al.
Journal of cellular biochemistry, 116(8), 1741-1754 (2015-03-05)
Promotion of insulin-secreting β-cell regeneration in patients with diabetes is a promising approach for diabetes therapy, which can contribute to rescue the uncontrolled hyperglycemia. Low-power laser irradiation (LPLI) has been demonstrated to regulate multiple physiological processes both in vitro and
Roberto Gedaly et al.
PloS one, 9(6), e99272-e99272 (2014-06-19)
Activation of the Wnt/β-catenin pathway has been observed in at least 1/3 of hepatocellular carcinomas (HCC), and a significant number of these have mutations in the β-catenin gene. Therefore, effective inhibition of this pathway could provide a novel method to
Giulia Zanni et al.
Developmental neuroscience, 37(3), 263-272 (2015-06-06)
Radiotherapy is common in the treatment of brain tumors in children but often causes deleterious, late-appearing sequelae, including cognitive decline. This is thought to be caused, at least partly, by the suppression of hippocampal neurogenesis. However, the changes in neuronal
Mini Bajaj et al.
Applied microbiology and biotechnology, 99(22), 9835-9846 (2015-08-01)
Extraction of chitin from mechanically pre-purified shrimp shells can be achieved by successive NaOH/HCl treatment, protease/HCl treatment or by environmentally friendly fermentation with proteolytic/lactic acid bacteria (LAB). For the last mentioned alternative, scale-up of shrimp shell chitin purification was investigated
Linlin Zhang et al.
International journal of nanomedicine, 10, 2913-2924 (2015-05-02)
Our prior screening of microRNAs (miRs) identified that miR-199a-3p expression is reduced in osteosarcoma cells, one of the most common types of bone tumor. miR-199a-3p exhibited functions of tumor cell growth inhibition, suggesting the potential application of miR-199a-3p as an
V de Brun et al.
Journal of animal physiology and animal nutrition, 99(4), 710-718 (2014-10-17)
This study investigated whether a 22-day period of undernutrition (half maintenance) could affect maternal endocrine responses and liver gene expression during early pregnancy (day 7). Thirty-five ewes were fed 1.5 (n = 15) or 0.5 (n = 20) their maintenance requirements and slaughtered on
Chiung-Kuei Huang et al.
Journal of hepatology, 63(1), 191-198 (2015-03-01)
Alcoholic liver disease (ALD) is characterized by the development of fatty liver, alcoholic hepatitis, fibrosis and cirrhosis. However, the underlying mechanism(s) associated with progression remains elusive. Pro-inflammatory cytokines have been implicated in ALD progression due to pro-apoptotic effects on hepatocytes.
Tomonaga Ichikawa et al.
Cellular signalling, 27(10), 2087-2098 (2015-07-26)
N-myc downstream-regulated gene 2 (NDRG2) is one of the important stress-inducible genes and plays a critical role in negatively regulating PI3K/AKT signaling during hypoxia and inflammation. Through recruitment of PP2A phosphatase, NDRG2 maintains the dephosphorylated status of PTEN to suppress
Haoyu Liu et al.
Carbohydrate polymers, 113, 480-489 (2014-09-27)
Polymer design and selection are crucial to the development of amorphous solid dispersions (ASD) for solubilization of otherwise poorly water-soluble drugs. The matrix polymer is required to interact strongly at the molecular level with the drug to prevent recrystallization, but
Jia-Hui Lin et al.
Physical chemistry chemical physics : PCCP, 17(23), 15124-15130 (2015-03-31)
This study describes the synthesis of fluorescent polydopamine dots (PDs) through hydroxyl radical-induced degradation of polydopamine nanoparticles. The decomposition of polydopamine nanoparticles to fluorescent PDs was confirmed using transmission electron microscopy and dark-field microscopy. The analysis of PDs by using
Ali Reza Kamali et al.
Nanoscale, 7(26), 11310-11320 (2015-06-09)
Experimental evidence for high temperature diffusion of hydrogen into the interlayer space of graphite is provided. This process is discussed as a possible method for the rapid production of high-quality, inexpensive graphene in large quantities, which could lead to the
Yoshikazu Taketa et al.
Journal of toxicologic pathology, 28(4), 217-224 (2015-11-06)
Magnetic resonance imaging (MRI) is a useful noninvasive tool used to detect lesions in clinical and veterinary medicine. The present study evaluated the suitability of a new easy-to-use compact MRI platform (M2 permanent magnet system, Aspect Imaging, Shoham, Israel) for
Vajihe Azimian-Zavareh et al.
Indian journal of pharmacology, 44(6), 714-721 (2012-12-19)
Glycogen synthase kinase-3β (GSK-3β) has been reported to be required for androgen receptor (AR) activity. This study sought to determine the usefulness of lithium chloride (LiCl) as a highly selective inhibitor of GSK-3β to increase the sensitivity of LNCap cells
F Vandenbussche et al.
Transboundary and emerging diseases, 62(5), 565-571 (2014-04-23)
Recently, a contamination incident was described in which the challenge inoculum used in a bluetongue virus serotype 8 (BTV-8) vaccination trial was contaminated with a BTV-11 virus that was closely related to the Belgian BTV-11 virus from 2008. This study
Jessica A Reusch et al.
Journal of virology, 89(3), 1731-1743 (2014-11-21)
Epstein-Barr virus (EBV) maintains a lifelong latent infection within a subset of its host's memory B cells, while lytic EBV replication takes place in plasma cells and differentiated epithelial cells. Therefore, cellular transcription factors, such as BLIMP1, that are key
Amir Reza Honarmand et al.
Pharmacology, biochemistry, and behavior, 122, 203-211 (2014-04-09)
The aim of this study was to investigate the interactive effect of lithium and atorvastatin on cognitive performance and the role of NO as a potential mechanism involved in this interaction. Memory performance was evaluated in a two-trial recognition Y-maze
Robin J Horst et al.
PLoS genetics, 11(7), e1005374-e1005374 (2015-07-24)
Stomata, valves on the plant epidermis, are critical for plant growth and survival, and the presence of stomata impacts the global water and carbon cycle. Although transcription factors and cell-cell signaling components regulating stomatal development have been identified, it remains
Gerson F Duarte Junior et al.
Electrophoresis, 36(16), 1935-1940 (2015-03-27)
This paper describes the use of ionic solutions as sensing electrodes for capacitively coupled contactless conductivity detection on electrophoresis microchips. Initially, two channels were engraved in a PMMA holder by using a CO2 laser system and sealed with a thin
Li Huang et al.
Bioactive materials, 6(10), 3074-3084 (2021-03-30)
Osteoporosis is a widely distributed disease that may cause complications such as accelerated tooth movement, bone resorption, and tooth loss during orthodontic treatment. Promoting bone formation and reducing bone resorption are strategies for controlling these complications. For several decades, the
Ulrike Lambertz et al.
BMC genomics, 16, 151-151 (2015-03-15)
Leishmania use exosomes to communicate with their mammalian hosts and these secreted vesicles appear to contribute to pathogenesis by delivering protein virulence factors to macrophages. In other eukaryotes, exosomes were found to carry RNA cargo, such as mRNAs and small
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