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L7757

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Song-Young Park et al.
American journal of physiology. Heart and circulatory physiology, 307(3), H346-H352 (2014-06-08)
Unlike cardiac and skeletal muscle, little is known about vascular smooth muscle mitochondrial respiration. Therefore, the present study examined mitochondrial respiratory rates in smooth muscle of healthy human feed arteries and compared with that of healthy cardiac and skeletal muscles.
Jyotsna Punj et al.
Middle East journal of anaesthesiology, 22(1), 71-77 (2013-07-10)
The aim of this study was to compare the clinical efficacy of 5% lignocaine, 2.5% lignocaine, 0.5% bupivacaine and 0.25% bupivacaine in subarachnoid block for pelvic surgeries. 80 adult ASA grades I and II patients of either sex between the
Bettina F Cuneo et al.
Circulation, 128(20), 2183-2191 (2013-11-13)
The electrophysiology of long QT syndrome (LQTS) in utero is virtually unstudied. Our goal here was to evaluate the efficacy of fetal magnetocardiography (fMCG) for diagnosis and prognosis of fetuses at risk of LQTS. We reviewed the pre/postnatal medical records
David S Rowlands et al.
Physiological genomics, 46(20), 747-765 (2014-08-21)
Epigenomic regulation of the transcriptome by DNA methylation and posttranscriptional gene silencing by miRNAs are potential environmental modulators of skeletal muscle plasticity to chronic exercise in healthy and diseased populations. We utilized transcriptome networks to connect exercise-induced differential methylation and
Hong Wan et al.
Journal of medicinal chemistry, 52(6), 1693-1700 (2009-03-05)
In CNS drug discovery, knowledge of drug-tissue binding is essential for a better understanding of brain penetration by assessing unbound brain to plasma ratio as well as pharmacokinetics (PK) and pharmacodynamics (PD) relationship by relating free drug concentration to pharmacological
X Meng et al.
Free radical research, 48(7), 823-838 (2014-04-12)
Notoginsenoside R1 (NGR1) is a novel phytoestrogen that is isolated from Panax notoginseng. We have recently found that NGR1 showed neuroprotection in vitro against oxidative stress through estrogen receptor (ER)-dependent activation of Akt/Nrf2 pathways. However, whether NGR1 has neuroprotective effect
Vincent Tedjasaputra et al.
The Journal of physiology, 593(14), 3147-3157 (2015-05-09)
Pulmonary gas exchange, as evaluated by the alveolar-arterial oxygen difference (A-aDO2), is impaired during intense exercise, and has been correlated with recruitment of intrapulmonary arteriovenous anastomoses (IPAVA) as measured by agitated saline contrast echocardiography. Previous work has shown that dopamine
R Christie et al.
Drug testing and analysis, 6(7-8), 651-657 (2013-08-01)
The discrimination of a cross section of cathinone regioisomers, sold as 'legal highs', using Raman spectroscopy, is reported here. Mephedrone and flephedrone were identified in 'legal high' products sold in Irish head shops, and their 2, 3 and 4-isomers were
Christian F Roman-Rodriguez et al.
Urology, 83(4), 893-898 (2013-11-28)
To compare retrospective use of oral sucrose (SUC) vs oral sucrose plus lidocaine ring block (SUC + RB) in the management of pain during neonatal circumcision. A retrospective review of medical records of newborns circumcised using the "Neonatal Infant Pain
C W Yang et al.
BMC palliative care, 14, 58-58 (2015-11-07)
Malignant esophageal obstruction leads to dysphagia, deterioration in quality of life, and malnutrition. Traditional bedside nasogastric (NG) tube placement is very difficult under these circumstances. However, endoscopically assisted NG tube placement under fluoroscopic guidance could be an alternative option for
V D Khokhlov et al.
Klinicheskaia meditsina, 90(7), 62-64 (2012-10-02)
A rare case of sudden fatal anaphylactic shock is described in a 50 year-old woman after secondary lidocaine blockade to relieve lumbar pain (the first blockade was performed 4 days before by the same physician after the negative skin test).
Roxana A Stefanescu et al.
Journal of neurophysiology, 113(3), 956-970 (2014-11-14)
Tinnitus has been associated with enhanced central gain manifested by increased spontaneous activity and sound-evoked firing rates of principal neurons at various stations of the auditory pathway. Yet, the mechanisms leading to these modifications are not well understood. In a
Comparison of postoperative redness of eyes after sub-Tenon's block and topical anaesthesia following phacoemulsification cataract surgery.
P Huang et al.
British journal of anaesthesia, 112(2), 381-382 (2014-01-17)
Carlo Bertucci et al.
Journal of chromatography. A, 1363, 150-154 (2014-08-16)
Levamisole, an anthelmintic drug, has been increasingly employed as an adulterant of illicit street cocaine over the last decade; recently, the use of tetramisole, the racemic mixture of levamisole and its enantiomer dexamisole, was also occasionally observed. A new enantioselective
iTMJ reduction.
Ronald L Hebard
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 151(6), 1086-1087 (2014-08-03)
Matthew D Muller et al.
American journal of physiology. Heart and circulatory physiology, 307(2), H228-H235 (2014-05-13)
Cardiac ischemia and angina pectoris are commonly experienced during exertion in a cold environment. In the current study we tested the hypotheses that oropharyngeal afferent blockade (i.e., local anesthesia of the upper airway with lidocaine) as well as systemic β-adrenergic
Joel L Cohen
Journal of drugs in dermatology : JDD, 12(9), 986-989 (2013-09-05)
Pain is a common patient complaint with dermatologic laser procedures and effective pain management is important for the comfort and satisfaction of patients undergoing these procedures. Many topical anaesthetics are available as options to decrease the pain associated with these
Ron L A P Hoogenboom et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 32(8), 1256-1264 (2015-06-30)
Lidocaine is a topical anaesthetic drug used in dairy cows for laparotomy (caesarean section, abomasal displacement). Because there are no registered drugs for this indication, it can be applied under the so-called Cascade rules (off-label use), with the restriction that
Improving the local anesthesia experience for our patients.
Gregori M Kurtzman
Dentistry today, 33(4), 120-120 (2014-05-06)
China Chien et al.
Journal of pediatric urology, 11(4), 197-197 (2015-06-17)
Pediatric urinary incontinence has been proposed as a cause for adult urinary incontinence, yet animal models mimic the findings of overactive bladder more closely than dysfunctional voiding. We used the bladder reduction (BR) model to study the effects of early
Carol T Bussey et al.
Cardiovascular diabetology, 13, 161-161 (2014-12-17)
Increasing numbers of type 2 diabetic and obese patients with enhanced rates of cardiovascular complications require surgical interventions, however they have a higher incidence of perioperative haemodynamic complications, which has been linked to adrenergic dysfunction. Therefore, we aimed to determine
Mark C Dessing et al.
Kidney international, 87(1), 85-94 (2014-06-19)
Upon ischemia/reperfusion (I/R)-induced injury, several damage-associated molecular patterns are expressed including the calcium-binding protein S100A8/A9 complex. S100A8/A9 can be recognized by Toll-like receptor-4 and its activation is known to deleteriously contribute to renal I/R-induced injury. To further test this, wild-type
Shawn S Winter et al.
Science (New York, N.Y.), 347(6224), 870-874 (2015-02-24)
Navigation depends on multiple neural systems that encode the moment-to-moment changes in an animal's direction and location in space. These include head direction (HD) cells representing the orientation of the head and grid cells that fire at multiple locations, forming
Katie L Poetz et al.
Biomacromolecules, 16(5), 1650-1659 (2015-04-14)
Surface eroding and semicrystalline polyanhydrides, with tunable erosion times and drug delivery pharmacokinetics largely dictated by erosion, are produced easily with thiol-ene "click" polymerization. This strategy yields both linear and cross-linked network polyanhydrides that are readily and fully cured within
Bin Cao et al.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 41(1), 53-58 (2014-12-19)
Use of a random skin flap is common for repairing wounds and for reconstruction. Lidocaine is a traditional local anesthetic that blocks sodium channels and has positive effects on ischemia-reperfusion injury. To investigate the effects of lidocaine on random skin
Elhadi H Aburawi et al.
European journal of drug metabolism and pharmacokinetics, 39(4), 293-299 (2013-11-21)
The hydrophobic amino acyl amide-linked local anesthetics (e.g., lidocaine and bupivacaine) impose potent cardiac toxicity and direct mitochondrial dysfunction. To investigate these adverse events, an in vitro system was employed to measure their effects on O2 consumption (cellular respiration) by
In reply.
Sandy M Hopper et al.
Annals of emergency medicine, 64(1), 97-97 (2014-06-22)
Fuat Bicer et al.
American journal of physiology. Renal physiology, 308(2), F103-F113 (2014-09-12)
The cause of chronic pelvic pain in interstitial cystitis/painful bladder syndrome (IC/PBS) remains unclear; autoimmunity is a possible etiology. We have recently shown that injection of a single immunogenic peptide of uroplakin 3A (UPK3A 65-84) induces experimental autoimmune cystitis (EAC)
Julio Rosales et al.
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, 34(11), 2093-2097 (2015-10-09)
The objective of this study was to describe a perisciatic ultrasound-guided infiltration technique for treatment of deep gluteal syndrome and to report its preliminary clinical results. A mixture of saline (20 mL), a local anesthetic (4 mL), and a corticosteroid
Zhichao Liu et al.
PLoS computational biology, 7(12), e1002310-e1002310 (2011-12-24)
Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be translated
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