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Marion Herbette et al.
Cells, 9(9) (2020-09-12)
Deposition of histone H3 lysine 4 (H3K4) methylation at promoters is catalyzed by the SET1/COMPASS complex and is associated with context-dependent effects on gene expression and local changes in chromatin organization. The role of SET1/COMPASS in shaping chromosome architecture has
Eric J Formeister et al.
The Annals of otology, rhinology, and laryngology, 124(1), 30-34 (2014-07-13)
This study aimed to illustrate the otorhinolaryngologic manifestations of levamisole toxicity and illuminate the features of this diagnosis. We describe a case of a known cocaine abuser with suspected levamisole toxicity who developed cutaneous necrosis of the cheeks, earlobes, nose
Kelly R Magliocca et al.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 71(3), 487-492 (2013-01-10)
Systemic complications of levamisole-adulterated cocaine (LAC) use have recently been described. The objective of this review is to increase awareness of these manifestations among oral and maxillofacial surgeons. LAC exposure through inhalation, nasal insufflation, or injection can induce cutaneous vasculopathy
Smrithi Rajendiran et al.
Molecular cancer, 13, 250-250 (2014-11-20)
MicroRNAs (miRNAs) are crucial molecules that regulate gene expression and hence pathways that are key to prostate cancer progression. These non-coding RNAs are highly deregulated in prostate cancer thus facilitating progression of the disease. Among the many genes that have
Alejandra González-Duarte et al.
The neuroradiology journal, 26(5), 511-513 (2013-11-10)
Cocaine-induced leukoencephalopathy is a rare neurological complication. It is most likely related to the substances used to adulterate the cocaine. Levamisole is one of the most common adulterants of cocaine and causes reversible leukoencephalopathy. Patients display severe neurological symptoms that
Agnes Cheong et al.
Development (Cambridge, England), 147(10) (2020-05-08)
Mitochondria are essential for energy production and although they have their own genome, many nuclear-encoded mitochondrial ribosomal proteins (MRPs) are required for proper function of the organelle. Although mutations in MRPs have been associated with human diseases, little is known
Natasha Purai Arora
The American journal of the medical sciences, 345(1), 45-51 (2012-12-28)
Levamisole has recently been implicated as a cause of cutaneous vasculopathy in cocaine abusers. The objective of this study was to describe this relatively new entity by reviewing published cases identified through a literature search. Published reports identified through a
Kinetics and inhibition of alkaline phosphatases from canine tissues.
H Van Belle
Biochimica et biophysica acta, 289(1), 158-168 (1972-11-10)
Anita Leocadio Freitas-Mesquita et al.
Experimental parasitology, 137, 8-13 (2013-12-10)
Several ecto-enzymatic activities have been described in the plasma membrane of the protozoan Leishmania amazonensis, which is the major etiological agent of diffuse cutaneous leishmaniasis in South America. These enzymes, including ecto-phosphatases, contribute to the survival of the parasite by
William Rietkerk et al.
Cutis, 91(1), 21-24 (2013-03-07)
We report a case of cocaine-induced small vessel vasculitis in a 51-year-old woman. We postulate that levamisole, an adulterant of cocaine, likely is the cause of this increase in cocaine-induced vasculitis. Based on a literature review, we suggest some helpful
Ana Mbokeleng Tsotetsi et al.
Tropical animal health and production, 45(3), 751-761 (2012-10-16)
The present study was conducted to determine the prevalence and distribution of gastrointestinal helminths, to detect the presence of anthelmintic resistance in livestock from small-scale farms and to determine the level of helminthosis awareness among small-scale farmers in Gauteng Province
André L A Dos-Santos et al.
Experimental parasitology, 135(2), 459-465 (2013-09-03)
The aim of this work was to investigate whether an alkaline ecto-phosphatase activity is present in the surface of Trypanosoma rangeli. Intact short epimastigote forms were assayed for ecto-phosphatase activity to study kinetics and modulators using β-glycerophosphate (β-GP) and p-nitrophenyl
[Bilateral necrosis of earlobes induced by cocaine].
Marta Bodro et al.
Medicina clinica, 140(5), e9-e9 (2013-01-08)
Xingxin Li et al.
Annals of hematology, 92(9), 1239-1247 (2013-04-27)
The appropriate management of patients with moderate aplastic anemia (mAA) remains to be unclear and controversial. A cohort of 118 patients with mAA received a novel immunosuppressive strategy of cyclosporine alternately combined with levamisole (CSA and LMS regimen), which included
Yongchan Lee et al.
Cell reports, 26(12), 3212-3220 (2019-03-21)
Metazoan cell death mechanisms are diverse and include numerous non-apoptotic programs. One program called entosis involves the invasion of live cells into their neighbors and is known to occur in cancers. Here, we identify a developmental function for entosis: to
Lei Guo et al.
Neuroscience bulletin, 35(2), 205-215 (2019-02-02)
The locus coeruleus (LC) has been studied in major depressive disorder (MDD) and bipolar disorder (BD). A major problem of immunocytochemical studies in the human LC is interference with the staining of the immunocytochemical end-product by the omnipresent natural brown
David S Lindsay et al.
Veterinary parasitology, 196(1-2), 21-23 (2013-03-26)
Decoquinate is a quinolone anticoccidial approved for use in the prevention of intestinal coccidiosis in farm animals. This compound has good activity against Toxoplasma gondii and Neospora caninum in cell cultures. The drug acts on the parasites' mitochondria. The activity
J T Sieker et al.
Osteoarthritis and cartilage, 23(3), 433-442 (2014-12-03)
Bone morphogenetic protein 2 (BMP-2, encoded by BMP2) and Indian hedgehog protein (IHH, encoded by IHH) are well known regulators of chondrogenesis and chondrogenic hypertrophy. Despite being a potent chondrogenic factor BMP-2 was observed to induce chondrocyte hypertrophy in osteoarthritis
Katarína Valachová et al.
Carbohydrate polymers, 134, 516-523 (2015-10-03)
The ability to protect hyaluronic acid (HA) from oxidative degradation by cupric ions and ascorbate (production of (•)OH and peroxy-type radicals) during acute phase joint inflammation has been investigated using the following drugs: tiopronin, captopril, and levamisole. Radical scavenging activity
Fouad Chiadmi et al.
Clinical laboratory, 59(3-4), 439-444 (2013-06-04)
The oral antihelmintic drug levamisole reduces sequestration of late stage parasites in falciparum malaria. Levamisole has been also identified as a cocaine adulterant. In the present study, authors developed a sensitive and selective HPLC-assay for the determination of levamisole in
Cocaine abuse and confidentiality: a case of retiform purpura in an adolescent patient.
Jenna L Streicher et al.
Journal of the American Academy of Dermatology, 70(6), 1127-1129 (2014-05-17)
Annemarie Rosan Kreeftmeijer-Vegter et al.
Expert opinion on drug delivery, 10(3), 293-300 (2013-01-08)
To develop an oral solid dosage form of levamisole suitable for the paediatric population in terms of dose accuracy, palatability, stability and ease of administration. Small undividable tablets (Ø5 - 8 mm) in four different strengths were manufactured to allow
Irene A Dy et al.
Seminars in thrombosis and hemostasis, 38(8), 780-782 (2012-10-09)
The syndrome of cocaine-levamisole thrombotic vasculopathy is a tetrad of cutaneous manifestations, arthralgia, leukopenia, and positive antineutrophil cytoplasmic antigen (ANCA). Cocaine is cut with levamisole to potentiate its euphoric effects. However, along with this are the adverse reactions of levamisole
Effects of levamisole and ranitidine on antibody-forming responses induced by killed Mycoplasma vaccine antigens in Saanen goats.
E M Temizel et al.
The Veterinary record, 171(23), 597-597 (2012-11-03)
Luke D Gardner et al.
The Journal of experimental biology, 222(Pt 21) (2019-10-11)
Cardiac remodeling results from both physiological and pathological stimuli. Compared with mammalian hearts, fish hearts show a broader array of remodeling changes in response to environmental influences, providing exceptional models for dissecting the molecular and cellular bases of cardiac remodeling.
Levamisole-induced vasculopathy: staging and management.
Joshua A Gillis et al.
Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 67(1), e29-e31 (2013-09-03)
Yeonjoong Yong et al.
Fitoterapia, 98, 184-191 (2014-07-16)
Semaphorins are a class of membrane-bound and secreted proteins. They have been found to regulate basic cell functions such as axonal growth cone guidance and recent studies have focused on their effect on tumor progression. Semaphorin 3B (Sema3B) particularly is
Andrea Taferner et al.
PloS one, 10(8), e0134161-e0134161 (2015-08-13)
The fumarylacetoacetate hydrolase (FAH) protein superfamily of metabolic enzymes comprises a diverse set of enzymatic functions, including ß-diketone hydrolases, decarboxylases, and isomerases. Of note, the FAH superfamily includes many prokaryotic members with very distinct functions that lack homologs in eukaryotes.
Kamryn N Gerner-Mauro et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(22), 12182-12191 (2020-05-18)
In multicellular organisms, paralogs from gene duplication survive purifying selection by evolving tissue-specific expression and function. Whether this genetic redundancy is also selected for within a single cell type is unclear for multimember paralogs, as exemplified by the four obligatory
Federica Boraldi et al.
The Journal of investigative dermatology, 133(4), 946-954 (2012-12-12)
Mineralization of elastic fibers in pseudoxanthoma elasticum (PXE) has been associated with low levels of carboxylated matrix gla protein (MGP), most likely as a consequence of reduced vitamin K (vit K) availability. Unexpectedly, vit K supplementation does not exert beneficial
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