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Olga A Sofyanovich et al.
PloS one, 14(5), e0216622-e0216622 (2019-05-10)
The role of glutathione (GSH) in eukaryotic cells is well known. The biosynthesis of this γ-glutamine tripeptide is well studied. However, other γ-glutamyl peptides were found in various sources, and the pathways of their formation were not always clear. The
HPLC determination of free nitrogenous compounds of Centaurea solstitialis (Asteraceae), the cause of equine nigropallidal encephalomalacia
Moret S, et al.
Toxicon, 46(6), 651-657 (2005)
Sungmi Song et al.
Cell death & disease, 11(2), 109-109 (2020-02-09)
By comparing imatinib-sensitive and -resistant chronic myeloid leukemia (CML) cell models, we investigated the molecular mechanisms by which tetrahydrobenzimidazole derivative TMQ0153 triggered caspase-dependent apoptosis at low concentrations accompanied by loss of mitochondrial membrane potential (MMP) and increase of cytosolic free
Tomáš Pazderka et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 185, 207-216 (2017-06-04)
The Raman spectra of 20 proteinogenic amino acids were recorded in the solution, glass phase (as drop coating deposition Raman (DCDR) samples) and crystalline forms in the wide spectral range of 200-3200cm
Huan Wang et al.
Frontiers in cell and developmental biology, 8, 620603-620603 (2021-03-23)
As one of the most common and lethal cancer, lung cancer severely threatens the health of human. It has been reported that tumor-associated macrophages promote initiation, progression, as well as chemoresistance in human cancers. However, the underneath molecular mechanism that
Sílvia M F Bessada et al.
Journal of toxicology and environmental health. Part A, 80(13-15), 641-650 (2017-05-20)
Coleostephus myconis (L.) Rchb.f. (Asteraceae) is a highly disseminated plant species with ruderal and persistent growth. Owing to its advantageous agronomic properties, C. myconis might have industrial applications. However, this species needs to be comprehensively characterized before any potential use.
Aleksej Zelezniak et al.
Cell systems, 7(3), 269-283 (2018-09-10)
A challenge in solving the genotype-to-phenotype relationship is to predict a cell's metabolome, believed to correlate poorly with gene expression. Using comparative quantitative proteomics, we found that differential protein expression in 97 Saccharomyces cerevisiae kinase deletion strains is non-redundant and
Stephanie Andraos et al.
Analytical biochemistry, 592, 113558-113558 (2020-01-09)
Amino acids (AAs) and one-carbon (1-C) metabolism compounds are involved in a range of key metabolic pathways, and mediate numerous health and disease processes in the human body. Previous assays have quantified a limited selection of these compounds and typically
Carmen Castro et al.
Archives of biochemistry and biophysics, 472(1), 26-33 (2008-02-12)
Using a redox-inert methyl acceptor, we show that betaine-homocysteine S-methyltransferase (BHMT) requires a thiol reducing agent for activity. Short-term exposure of BHMT to reducing agent-free buffer inactivates the enzyme without causing any loss of its catalytic zinc. Activity can be
Jae Woo Jung et al.
Cell metabolism, 29(6), 1306-1319 (2019-04-09)
The mechanistic target of rapamycin complex (mTORC1) is a signaling hub on the lysosome surface, responding to lysosomal amino acids. Although arginine is metabolically important, the physiological arginine sensor that activates mTOR remains unclear. Here, we show that transmembrane 4 L
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