In children, CNS-directed cancer therapy is thought to result in decreased cerebral white matter volumes (WMV) and subsequent neurocognitive deficits. This study was designed as a prospective validation of the purported reduction in WMV, associated influential factors, and its relationship...
Drugs of today (Barcelona, Spain : 1998), 49(10), 647-665 (2013-11-06)
Attention deficit hyperactivity disorder (ADHD) is a neurobehavioral developmental disorder in children and adults characterized by a persistent pattern of impulsiveness, inattention and hyperactivity. It affects about 3-10% of children and 2-5% of adolescents and adults and occurs about four...
Children and adolescents with attention-deficit/hyperactivity disorder (ADHD) are prone to sustaining trauma that requires emergency department (ED) admission. Methylphenidate (MPH) can reduce ADHD symptoms and may thus theoretically reduce the risk of trauma-related ED admission, but previous studies do not...
Biased reporting of results in patients at ultra-high risk of psychosis.
Andrew James Amos
The Journal of clinical psychiatry, 74(11), 1123-1123 (2013-12-18)
Attention deficit/hyperactivity disorder (ADHD) is attributed to dysfunction of the prefrontal cortex. Methylphenidate, an inhibitor of dopamine and norepinephrine transporters (DAT and NET, respectively), is a standard treatment for ADHD. The Spontaneously Hypertensive Rat (SHR) is a well-established animal model...
Santos et al. reply.
André Palmini et al.
Developmental medicine and child neurology, 55(10), 967-967 (2013-08-09)
Praxis, 102(14), 877-878 (2013-07-05)
The impact of methylphenidate on seizure frequency and severity in children with attention-deficit-hyperactivity disorder and difficult-to-treat epilepsies.
Andreas Brunklaus et al.
Developmental medicine and child neurology, 55(10), 966-967 (2013-06-04)
[The pills are also effective in the dog].
MMW Fortschritte der Medizin, 156(21-22), 8-8 (2015-01-23)
Recenti progressi in medicina, 104(6), 254-261 (2013-06-27)
The Register was aimed at assessing the benefit-risk profile of the treatment of attention deficit hyperactivity disorder (ADHD) with atomoxetine and methylphenidate. Post-marketing observational study, phase IV. Prescription medication to children and adolescents with ADHD aged between 6 and 18...
Expert opinion on pharmacotherapy, 12(2), 315-324 (2011-01-14)
Attention deficit/hyperactivity disorder (ADHD) is estimated to affect 4-5% of adults. Impairment across multiple domains of daily living can be mild to serious. OROS methylphenidate (MPH) was evaluated in two large adult clinical trials, and in 2008 it was approved...
Research in developmental disabilities, 34(9), 2551-2563 (2013-06-12)
Data on psychopharmacological treatment of individuals with autism spectrum disorder (ASD) are scarce, especially for European countries. This study evaluated psychopharmacotherapy utilisation in children and adolescents with a diagnosis of ASD in Germany. Data of a large statutory health insurance...
Celgene has developed a chirally pure form of methylphenidate (Ritalin), called dexmethylphenidate [d-methylphenidate, d-methylphenidate hydrochloride, d-MPH; Focalin]. The drug has been launched in the USA and is undergoing registration in Canada for the treatment of children with attention-deficit hyperactivity disorder...
Journal of attention disorders, 19(1), 63-71 (2012-07-28)
The Child Behavior Checklist-Dysregulation Profile (CBCL-DP), characterized by elevated scores on the "Attention Problems," "Aggressive Behavior," and "Anxious/Depressed" scales in the CBCL, has been associated with later severe psychopathology. In a sample of children with ADHD, this study sought to...
There may be costs to failing to enhance, as well as to enhancing.
The American journal of bioethics : AJOB, 13(7), 38-39 (2013-06-19)
The US Agency for Healthcare Research and Quality sponsored a comparative effectiveness review of interventions for preschoolers at risk for attention-deficit/hyperactivity disorder (ADHD). Medline, Cochrane CENTRAL, Embase, PsycInfo, and Education Resources Information Center were searched from 1980 to November 24...
Current models of ADHD suggest abnormal reward and punishment sensitivity, but the exact mechanisms are unclear. This study aims to investigate effects of continuous reward and punishment on the processing of performance feedback in children with ADHD and the modulating...
The possible effect of methylphenidate on kleptomania in a school-age girl with attention-deficit/hyperactivity disorder.
Savaş Yılmaz et al.
European child & adolescent psychiatry, 23(5), 361-363 (2013-10-15)
Brain : a journal of neurology, 136(Pt 11), 3252-3270 (2013-10-29)
Through the combined use of (18)F-fallypride positron emission tomography and magnetic resonance imaging this study examined the neural mechanisms underlying the attentional deficits associated with attention deficit/hyperactivity disorder and their potential reversal with a single therapeutic dose of methylphenidate. Sixteen...
Response to letter that comments on published paper: The use of stimulant medication to improve neurocognitive and learning outcomes in children diagnosed with brain tumours: A systematic review.
Emile F Smithson et al.
European journal of cancer (Oxford, England : 1990), 50(8), 1569-1570 (2014-03-22)
The Journal of pharmacology and experimental therapeutics, 345(3), 374-382 (2013-04-13)
It has been hypothesized that drugs that serve as substrates for dopamine (DA) and norepinephrine (NE) transporters may be more suitable medications for cocaine dependence than drugs that inhibit DA and NE uptake by binding to transporters. Previous studies have...
Journal of attention disorders, 18(8), 699-712 (2012-08-11)
This pilot study tested the short- and long-term efficacy (9 weeks follow-up) of an executive functioning (EF) remediation training with game elements for children with ADHD in an outpatient clinical setting, using a randomized controlled wait-list design. Furthermore, in a...
A liberal consequentialist approach to regulation of cognitive enhancers.
The American journal of bioethics : AJOB, 13(7), 53-55 (2013-06-19)
More attention to ADHD.
Developmental medicine and child neurology, 55(4), 296-296 (2013-03-16)
The present study is a randomized controlled trial that aims to evaluate the efficacy of Neurofeedback compared to standard pharmacological intervention in the treatment of attention deficit/hyperactivity disorder (ADHD). The final sample consisted of 23 children with ADHD (11 boys...
Regulating methylphenidate: enhancing cognition and social inequality.
C D Brewer et al.
The American journal of bioethics : AJOB, 13(7), 47-49 (2013-06-19)
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(1), 161-169 (2015-01-09)
Positive social interactions during the juvenile and adolescent phases of life, in the form of social play behavior, are important for social and cognitive development. However, the neural mechanisms of social play behavior remain incompletely understood. We have previously shown...
Methylphenidate in the management of cancer-related fatigue.
Patrick C Stone
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(19), 2372-2373 (2013-05-22)
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