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T T H Pham et al.
Biochimie, 107 Pt A, 143-153 (2014-06-22)
Visceral leishmaniasis is a life-threatening disease that affects nearly a million people every year. The emergence of Leishmania strains resistant to existing drugs complicates its treatment. The purpose of this study was to develop a new lipid formulation based on
Maya Nakamura et al.
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 183(1), 51-59 (2012-07-28)
A key evolutionary development facilitating land colonization in terrestrial isopods (Isopoda: Oniscidea) is the intermittent liberation of waste nitrogen as volatile ammonia. Intermittent ammonia release exploits glutamine (Gln) as an intermediary nitrogen store. Here, we explore the relationship between temporal
Myong-Ho Jeong et al.
Nature communications, 5, 5455-5455 (2014-11-20)
Canonical Wnt signalling regulates expansion of neural progenitors and functions as a dorsalizing signal in the developing forebrain. In contrast, the multifunctional co-receptor Cdo promotes neuronal differentiation and is important for the function of the ventralizing signal, Shh. Here we
Swelling equilibria and dye adsorption studies of chemically crosslinked superabsorbent acrylamide/maleic acid hydrogels.
Karadag E, et al.
Eur. Polymer J., 38(11), 2133-2141 (2002)
Marek Drozd et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 89, 243-251 (2012-01-24)
On the basis of experimental literature data the theoretical studies for guanidinium and maleic acid complex with using DFT method are performed. In these studies the experimental X-ray data for two different forms of investigated crystal were used. During the
B J Snider et al.
Neuroscience, 120(3), 617-625 (2003-08-05)
Glutamate-mediated excitotoxicity might contribute to the pathogenesis of Huntington's disease and other polyglutamine repeat disorders. We used murine neocortical cultures derived from transgenic and knock-in mice to test the effect of expression of expanded polyglutamine-containing huntingtin on neuronal vulnerability to
Hanna Kotikoski et al.
Acta ophthalmologica Scandinavica, 81(4), 355-360 (2003-07-16)
To investigate whether a nitric oxide donor given as a single oral dose is able to modify aqueous humour flow in healthy volunteers. Ten healthy volunteers participated in a randomized, double-masked and placebo-controlled cross-over study. Aqueous humour flow was assessed
Vidya P Nair et al.
Bio-protocol, 7(7), e2199-e2199 (2017-04-05)
RNA-dependent RNA polymerase (RdRp) is essential for the replication of viral RNA for RNA viruses. It synthesizes the complementary strand of viral genomic RNA, which is used subsequently as a template to generate more copies of viral genome. This assay
Carmen María Ferrer-Luque et al.
Journal of endodontics, 38(6), 826-828 (2012-05-19)
The use of chelating agents in endodontic treatment is required to remove the smear layer and to achieve better disinfection within the root canal system. The aim of this study was to evaluate the residual antimicrobial activity of 17% ethylenediaminetetraacetic
R M Gallagher
Headache, 29(6), 366-367 (1989-06-01)
The treatment of patients suffering with menstrual migraine is sometimes a difficult and frustrating problem for the physician. As many menstrual migraine headaches are refractory to abortive therapy, prophylactic therapy is often needed. Ergonovine maleate, an ergot derivative with vasoconstrictive
Sophie Badie et al.
The EMBO journal, 34(3), 410-424 (2015-01-15)
Loss of telomere protection occurs during physiological cell senescence and ageing, due to attrition of telomeric repeats and insufficient retention of the telomere-binding factor TRF2. Subsequently formed telomere fusions trigger rampant genomic instability leading to cell death or tumorigenesis. Mechanistically
Mark Berlin et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 93, 267-280 (2015-04-15)
Many active pharmaceutical ingredients (APIs) exhibit a highly variable pharmacokinetic (PK) profile. This behavior may be attributable to pre-absorptive, absorptive and/or post-absorptive factors. Pre-absorptive factors are those related to dosage form disintegration, drug dissolution, supersaturation, precipitation and gastric emptying. Absorptive
P Pandi et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 88, 77-81 (2012-01-10)
Synthesis and growth of a novel organic nonlinear optical (NLO) crystal of 4-aminopyridinium maleate (4APM) in larger size by the slow evaporation solution growth technique are reported. Single crystal and powder X-ray diffraction analyses reveal that 4APM crystallizes in monoclinic
M Lavit et al.
Arzneimittel-Forschung, 50(7), 640-644 (2000-08-31)
A simple and sensitive HPLC method has been developed to measure trimebutine (CAS 39133-31-8, maleate: CAS 34140-59-5) and its main metabolite desmethyl-trimebutine in human plasma. The method was validated according to the Washington Consensus Conference on the Validation of Analytical
Ursula Thormann et al.
Journal of pharmaceutical sciences, 103(10), 3139-3152 (2014-09-02)
The objective of this work was first to investigate the chemical degradation of the sesquiterpene lactone nobilin and determine its solubility under conditions of concurrent degradation for partially amorphous starting material; second, to determine the effect of biorelevant media used
Esterification of maleic acid with ethanol over cation-exchange resin catalysts.
Yadav GD and Thathagar MB.
Reactive functional Polymers, 52(2), 99-110 (2002)
Pierangelo Gobbo et al.
Langmuir : the ACS journal of surfaces and colloids, 28(33), 12357-12363 (2012-08-14)
Improved methodology to prepare maleimide-functionalized, water-soluble, small (<3 nm) gold nanoparticles using a retro-Diels-Alder strategy that we developed for similar organic-soluble AuNP's is described. Importantly, our results suggest that a recent paper by Zhu, Waengler, Lennox, and Schirrmacher describing a
Determination of total dietary fibre and available carbohydrates: A rapid integrated procedure that simulates in vivo digestion.
McCleary BV, et al.
Starch, 67(9-10), 860-883 (2015)
Atsushi Kambayashi et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 87(2), 236-243 (2014-01-28)
The objective of this research was to characterize the dissolution profile of a poorly soluble drug, diclofenac, from a commercially available multiple-unit enteric coated dosage form, Diclo-Puren® capsules, and to develop a predictive model for its oral pharmacokinetic profile. The
Hayley Thompson et al.
Applied and environmental microbiology, 81(24), 8307-8314 (2015-09-27)
Around a third of oral bacteria cannot be grown using conventional bacteriological culture media. Community profiling targeting 16S rRNA and shotgun metagenomics methods have proved valuable in revealing the complexity of the oral bacterial community. Studies investigating the role of
Bromine-Catalyzed Isomerization of Maleic Acid to Fumaric Acid.
Jwo JJ.
J. Chin. Chem. Soc., 28(1), 34-41 (1981)
Johanna E M Kraus et al.
EvoDevo, 6, 23-23 (2015-06-16)
The metagenesis of sessile polyps into pelagic medusae in cnidarians represents one of the most ancient complex life cycles in animals. Interestingly, scyphozoans and hydrozoans generate medusae by apparently fundamentally different processes. It is therefore unclear whether medusa formation has
Hanno C Erythropel et al.
Chemosphere, 86(8), 759-766 (2011-11-25)
The plasticizer di (2-ethylhexyl) phthalate (DEHP) and its metabolites are considered ubiquitous contaminants, which have a range of implications on the environment and human health. This work considered several alternative compounds with structural features similar to DEHP. This added to
A refinement of the crystal structure of maleic acid.
James MNG and Williams GJB.
Acta Crystallographica Section B, Structural Science, 30(5), 1249-1257 (1974)
A De Luca et al.
Cerebellum (London, England), 14(2), 72-85 (2014-09-24)
All cerebellar GABAergic interneurons were derived from a common pool of precursor cells residing in the embryonic ventricular zone (VZ) and migrating in the prospective white matter (PWM) after birth, where both intrinsic and extrinsic factors contribute to regulate their
Aurora I Idilli et al.
STAR protocols, 2(2), 100569-100569 (2021-06-18)
Alternative lengthening of telomeres (ALT) is a telomerase-independent, recombination-based telomere maintenance mechanism that allows cancer cells to acquire unlimited proliferative capacity. The C-circle assay (CCA) has emerged as the gold standard for quantitative measurement of ALT activity. Here, we present
Carola Städele et al.
Bio-protocol, 7(5), e2151-e2151 (2017-03-05)
This is a detailed protocol explaining how to perform extracellular axon stimulations as described in Städele and Stein, 2016. The ability to stimulate and record action potentials is essential to electrophysiological examinations of neuronal function. Extracellular stimulation of axons traveling
Shirley A Aguirre et al.
Toxicologic pathology, 40(5), 797-806 (2012-05-04)
Maleic acid was formulated in 0.7% saline and injected intravitreally in rabbits in order to evaluate ocular safety and tolerability. Maleic acid was formulated within a narrow pH range (2-3), administered in a fixed volume (100 µl), and concentrations ranged
J M Herreras et al.
Ophthalmology, 99(7), 1082-1088 (1992-07-01)
This study was undertaken to see whether long-term locally applied ocular medications produced any alterations in the ocular surface, and, in particular, whether it caused damage to the mucus layer of the tear film. The authors studied the ocular surface
R G Turcan et al.
Drug metabolism and disposition: the biological fate of chemicals, 21(6), 1037-1047 (1993-11-01)
This study describes the disposition of [14C]velnacrine maleate in rats, dogs, and humans, and the isolation and identification of metabolites in dog urine. Following oral administration of [14C]velnacrine maleate, drug-related material was well absorbed in all three species, with the
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