Showing 1-30 of 224 results for "M0639"
Robert J Fox et al.
Neurology, 82(17), 1491-1498 (2014-04-01)
RESTORE was a randomized, partially placebo-controlled exploratory study evaluating multiple sclerosis (MS) disease activity during a 24-week interruption of natalizumab. Eligible patients were relapse-free through the prior year on natalizumab and had no gadolinium-enhancing lesions on screening brain MRI. Patients...
Zhengming Gu et al.
Archives of pathology & laboratory medicine, 138(11), 1474-1480 (2014-10-31)
Invasive fungal infections are an important cause of morbidity and mortality among immunocompromised patients. To design and evaluate a multiplexed assay aimed at quantitative detection and differentiation of the 5 molds that are most commonly responsible for pulmonary infections. Using...
Ruple S Laughlin et al.
Mayo Clinic proceedings, 89(4), 454-461 (2014-01-09)
To identify whether new ipsilateral weakness after hip surgery may be due to an inflammatory as opposed to a mechanical process. Seven patients (8 hip surgeries) seen between July 1, 2008, and June 30, 2011, developed unexplained ipsilateral leg weakness...
Jean-François Augusto et al.
Transplantation, 97(11), 1155-1160 (2014-04-02)
New-onset diabetes after transplantation (NODAT) is a frequent condition associated with a poor outcome. In kidney transplantation, hypomagnesemia is a frequent posttransplant complication and has been associated with calcineurin inhibitors use. Previous studies have analyzed the relationship between posttransplant hypomagnesemia...
Mienke Rijsdijk et al.
Anesthesia and analgesia, 118(5), 1097-1112 (2014-05-02)
Methylprednisolone acetate (MPA) has a long history of use in the treatment of sciatic pain and other neuropathic pain syndromes. In several of these syndromes, MPA is administered in the epidural space. On a limited basis, MPA has also been...
M Toledano et al.
Neurology, 82(18), 1578-1586 (2014-04-08)
To evaluate a trial of immunotherapy as an aid to diagnosis in suspected autoimmune epilepsy. We reviewed the charts of 110 patients seen at our autoimmune neurology clinic with seizures as a chief complaint. Twenty-nine patients met the following inclusion...
Erhan Ayhan et al.
Skinmed, 11(3), 185-187 (2013-08-13)
A 74-year-old man presented with muscle weakness in both legs for a duration of 2 months. Physical examination revealed periorbital edema and erythema, erythema on the neck and chest, erythematous papules on the proximal-distal interphalangeal and metocarpophalangeal joints, crusted plaque...
Immunoregulation therapy changes the frequency of interleukin (IL)-22+ CD4+ T cells in systemic lupus erythematosus patients.
Zhao L, Ma H, Jiang Z, et al.
Clinical and Experimental Immunology, 177(1), 212-218 (2014)
Virginia Fernandes Moça Trevisani et al.
The Cochrane database of systematic reviews, 2(2), CD002265-CD002265 (2013-03-02)
Neuropsychiatric involvement in systemic lupus erythematosus (SLE) is complex and it is an important cause of morbidity and mortality. Management of nervous system manifestations of SLE remains unsatisfactory. This is an update of a Cochrane review first published in 2000...
Vladimir Trkulja et al.
Therapeutic drug monitoring, 36(4), 456-464 (2014-02-13)
Two oral mycophenolic acid (MPA) formulations, immediate-release mycophenolate mofetil and enteric-coated mycophenolate sodium, have been shown to differ regarding some drug-drug interactions. The aim was to assess whether the effects of cyclosporine (CsA) on steady-state pharmacokinetics (PK) of MPA in...
Hiroshi Nishida et al.
Nihon rinsho. Japanese journal of clinical medicine, 66(6), 1190-1194 (2008-06-11)
An open study in the Netherlands have investigated the efficacy of combination therapy with methylprednisolone(mPSL) and high-dose immunoglobulin (IVIg) for Guillain-Barré syndrome (GBS) patients. The study suggested that the combination therapy is more effective than treatment with IVIg alone. Following...
Amy L Samuels et al.
British journal of haematology, 165(1), 57-66 (2014-01-25)
Drug-resistant forms of acute lymphoblastic leukaemia (ALL) are a leading cause of death from disease in children. Up to 25% of patients with T-cell ALL (T-ALL) develop resistance to chemotherapeutic agents, particularly to glucocorticoids (GCs), a class of drug to...
Karima Boubaker et al.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 24(3), 571-575 (2013-05-04)
Euphorbia paralias is known in traditional medicine as an anti-inflammatory agent, a purgative and for its local anesthetic property. To the best our knowledge, renal toxicity of this substance has not been previously reported. In this paper, we report the...
Dimitra Molyva et al.
Pharmacological reports : PR, 66(6), 952-955 (2014-12-03)
Activation of histamine H1 receptor (H1R) is a well-known hallmark of allergic and inflammatory pathology. Both types of bradykinin receptors (B1R and B2R) are also known to contribute significantly to the latter and some sort of functional interaction between them...
M Tyblova et al.
European journal of neurology, 22(4), 624-632 (2014-06-17)
The prevalence of osteopenia and osteoporosis is higher amongst patients with multiple sclerosis in comparison with the general population. In addition to the general determinants of bone health, two factors may contribute to reduced bone mineral density in multiple sclerosis:...
Zhenglei Xu et al.
International journal of clinical and experimental medicine, 8(4), 6193-6199 (2015-07-02)
This study aims to compare the safety and curative effect of celecoxib and small-dose methylprednisolone sodium succinate in patients with peptic ulcer hemorrhage combined with acute gout. In this randomized, controlled trial, a total of 136 patients with peptic ulcer...
Ricardo Vieira Botelho et al.
Revista da Associacao Medica Brasileira (1992), 55(6), 729-737 (2010-03-02)
Steroid therapy has been tested as a protector in spinal cord injury. Multicenter studies evaluating the methylprednisolone (MP) in post traumatic neurological recovery have shown promising results according to NASCIS. A large number of critical studies related to the NASCIS...
Thomas Sersté et al.
Liver international : official journal of the International Association for the Study of the Liver, 35(8), 1974-1982 (2015-01-23)
The beneficial effect of nonselective beta-blockers (NSBB) has recently been questioned in patients with end-stage cirrhosis. We analysed the impact of NSBB on outcomes in severe alcoholic hepatitis (AH). This study was based on a prospective database of patients with...
Xinghuo Wu et al.
International journal of immunopathology and pharmacology, 28(3), 351-361 (2015-07-23)
The phenotypic polarization of macrophages are involved in steroid-induced osteonecrosis (ON). This study tried to investigate the detrimental and beneficial roles of M1/M2 macrophages associated with TNF-a in ON. Mice ON model was induced by the injection of methylprednisolone. After...
Corticosteroids for severe community-acquired pneumonia: not for everyone.
Richard G Wunderink
JAMA, 313(7), 673-674 (2015-02-18)
Zhichao Liu et al.
PLoS computational biology, 7(12), e1002310-e1002310 (2011-12-24)
Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be translated...
In Hwan Cho et al.
Journal of glaucoma, 24(1), 81-83 (2013-02-23)
To report a case of bilateral simultaneous angle-closure glaucoma caused by septic condition of Korean hemorrhagic fever. A 62-year-old man visited our emergency center with signs of sepsis (fever, leukocytosis, and oliguria). After 4 days of hospitalization, the patient reported...
Aysha Z Akhtar et al.
Alternatives to laboratory animals : ATLA, 37(1), 43-62 (2009-03-19)
The objective of this study was to examine whether animal studies can reliably be used to determine the usefulness of methylprednisolone (MP) and other treatments for acute spinal cord injury (SCI) in humans. This was achieved by performing a systematic...
MMWR. Morbidity and mortality weekly report, 62(19), 377-381 (2013-05-17)
As of May 6, 2013, Michigan had reported 167 (52%) of the 320 paraspinal or spinal infections without meningitis associated with the 2012-2013 fungal meningitis outbreak nationally. Although the index patient had a laboratory-confirmed Aspergillus fumigatus infection, the fungus most...
A case of opsoclonus-myoclonus syndrome following a septic shock.
A Daumas et al.
Anaesthesia and intensive care, 41(6), 810-811 (2013-11-05)
Fungal meningitis outbreak affects over 700.
Carrie Arnold
The Lancet. Neurology, 12(5), 429-430 (2013-04-23)
Richard W Browne et al.
Journal of neurology, neurosurgery, and psychiatry, 85(8), 859-864 (2014-01-29)
There is increasing evidence that serum lipoprotein cholesterol biomarkers are associated with disease progression in clinically isolated syndromes (CIS). Apolipoproteins (Apo) are recognition ligands that mediate the physiological interactions of cholesterol-containing lipoproteins. The objective of this study was to investigate...
Guillermo Ruiz-Irastorza et al.
Autoimmunity reviews, 13(2), 206-214 (2013-11-06)
To assess the effectiveness and safety of a protocol using medium doses of prednisone to treat lupus nephritis. Patients receiving the 'Cruces-protocol cohort' (CPC) were paired 1:2 with patients from the 'historic cohort' (HC). The CPC received medium doses of...
Zaid Al-Nakeeb et al.
Antimicrobial agents and chemotherapy, 59(5), 2735-2745 (2015-02-26)
Amphotericin B is a first-line agent for the treatment of invasive aspergillosis. However, relatively little is known about the pharmacodynamics of amphotericin B for invasive pulmonary aspergillosis. We studied the pharmacokinetics (PK) and pharmacodynamics (PD) of amphotericin B deoxycholate (DAMB)...
Zhihong Liu et al.
Annals of internal medicine, 162(1), 18-26 (2014-11-11)
Treatment of lupus nephritis (LN) remains challenging. To assess the efficacy and safety of a multitarget therapy consisting of tacrolimus, mycophenolate mofetil, and steroid compared with intravenous cyclophosphamide and steroid as induction therapy for LN. 24-week randomized, open-label, multicenter study....

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