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Eveline Dischkaln Stolz et al.
The Journal of pharmacy and pharmacology, 66(12), 1774-1785 (2014-08-15)
Investigate the involvement of monoaminergic and glutamatergic systems on the antinociceptive and ataxic effects of uliginosin B, which we have already demonstrated to be a promising molecular scaffold to develop new analgesic drugs. Uliginosin B was obtained from hexane extract
Erin J Kodis et al.
Alzheimer's & dementia : the journal of the Alzheimer's Association, 14(10), 1302-1312 (2018-10-09)
Alzheimer's disease (AD) symptoms reflect synaptic dysfunction and neuron death. Amyloid-β oligomers (AβOs) induce excess calcium entry into neurons via N-methyl-D-aspartate receptors (NMDARs), contributing to synaptic dysfunction. The study described here tested the hypothesis that AβO-stimulated calcium entry also drives
Hiroshi Ueno et al.
BMC neuroscience, 21(1), 19-19 (2020-05-03)
Empathy refers to the ability to recognise and share emotions with others. Several research groups have recognised observational fear in mice as a useful behavioural model for assessing their ability to empathise. However, in these observation systems, it remains unclear
A F Iakimovskiĭ et al.
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 99(2), 221-229 (2013-05-09)
The influence of NMDA and metabotropic neostriatal glutamate receptors blockade to avoidance conditioning (in shuttle box) and free locomotor behavior (in open field) in chronic experiments in rats were investigated. The glutamate receptor antagonists were injected bilateral into striatum separately
Felipe Baeza-Lehnert et al.
Cell metabolism, 29(3), 668-680 (2018-12-12)
Neurons have limited intracellular energy stores but experience acute and unpredictable increases in energy demand. To better understand how these cells repeatedly transit from a resting to active state without undergoing metabolic stress, we monitored their early metabolic response to
Lu Wang et al.
Frontiers in cellular neuroscience, 13, 586-586 (2020-03-03)
The reelin haploinsufficient heterozygous reeler mice (HRM), an animal model of schizophrenia, have altered mesolimbic dopaminergic pathways and share similar neurochemical and behavioral properties with patients with schizophrenia. Dysfunctional neural circuitry with impaired gamma (γ) oscillation (30-80 Hz) has been
D N Nandakumar et al.
Physiology international, 106(3), 250-260 (2019-10-01)
Glioblastoma cells create glutamate-rich tumor microenvironment, which initiates activation of ion channels and modulates downstream intracellular signaling. N-methyl-D-aspartate receptors (NMDARs; a type of glutamate receptors) have a high affinity for glutamate. The role of NMDAR activation on invasion of glioblastoma
Robert W Flint et al.
Neurobiology of learning and memory, 101, 114-119 (2013-02-09)
The characteristics of memory consolidation, reconsolidation, and state dependency have received considerable attention for many years. Three experiments examined the effects of the NMDA antagonist MK-801 on these phenomena in adolescent rats using passive avoidance conditioning. Experiment 1 demonstrated that
The NMDA antagonist MK-801 causes marked locomotor stimulation in monoamine-depleted mice.
Carlsson M and Carlsson A
Journal of Neural Transmission. General Section, 75(3), 221-226 (1989)
Daniel R Thomases et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(1), 26-34 (2013-01-04)
A developmental disruption of prefrontal cortical inhibitory circuits is thought to contribute to the adolescent onset of cognitive deficits observed in schizophrenia. However, the developmental mechanisms underlying such a disruption remain elusive. The goal of this study is to examine
Etsuo A Susaki et al.
Nature communications, 11(1), 1982-1982 (2020-04-29)
Whole-organ/body three-dimensional (3D) staining and imaging have been enduring challenges in histology. By dissecting the complex physicochemical environment of the staining system, we developed a highly optimized 3D staining imaging pipeline based on CUBIC. Based on our precise characterization of
Tao Wang et al.
Experimental parasitology, 135(3), 497-502 (2013-09-04)
Schizophrenia is a serious neuropsychiatric disease of uncertain etiology, which causes human mental disorder and affects about 1% of the population. In recently years, some studies showed that some cases of schizophrenia may be associated with Toxoplasma gondii infection. In
Helmut W Kessels et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(10), 4033-4038 (2013-02-23)
The mechanisms by which β-amyloid (Aβ), a peptide fragment believed to contribute to Alzheimer's disease, leads to synaptic deficits are not known. Here we find that elevated oligomeric Aβ requires ion flux-independent function of NMDA receptors (NMDARs) to produce synaptic
David Petri et al.
Behavioural brain research, 252, 58-67 (2013-06-04)
The subthalamic nucleus (STN) has a pivotal role in the pathophysiology of Parkinson's disease (PD). Modulation of STN activity (by lesions, pharmacological or electrical stimulation) has been shown to improve motor parameters in PD patients and in animal models of
Emma L Morris et al.
The EMBO journal, 40(20), e108614-e108614 (2021-09-07)
Circadian rhythms in mammals are governed by the hypothalamic suprachiasmatic nucleus (SCN), in which 20,000 clock cells are connected together into a powerful time-keeping network. In the absence of network-level cellular interactions, the SCN fails as a clock. The topology
Ling-Zong Hong et al.
The Chinese journal of physiology, 55(5), 337-345 (2013-01-04)
It is known that enrichment of glutamatergic transmission in the nucleus tractus solitarii (NTS) plays an important role in central cardiovascular regulation. Our previous study demonstrated that nicotine decreased blood pressure and heart rate in the NTS probably acting via
Keisuke Migita et al.
Journal of pharmacological sciences, 142(2), 50-59 (2019-12-11)
Cholinergic neurons play an important role in the higher functions of the brain, such as the memory, cognition, and nociception. However, the exact mechanism behind how the stimulation of all the muscarinic M1 receptors in the entire brain results in
Ahmad Salamian et al.
Cerebral cortex (New York, N.Y. : 1991), 31(8), 3804-3819 (2021-03-20)
Information coding in the hippocampus relies on the interplay between various neuronal ensembles. We discovered that the application of a cholinergic agonist, carbachol (Cch), which triggers oscillatory activity in the gamma range, induces the activity of matrix metalloproteinase 9 (MMP-9)-an
Ethan M Anderson et al.
The Journal of pharmacology and experimental therapeutics, 355(3), 496-505 (2015-09-18)
Opioid withdrawal causes a dysphoric state that can lead to complications in pain patients and can propagate use in drug abusers and addicts. Opioid withdrawal changes the activity of neurons in the nucleus accumbens, an area rich in both opioid-binding
Zhi-Wen Luo et al.
International journal of ophthalmology, 12(8), 1250-1261 (2019-08-29)
To establish a model of retinal neurodegeneration induced by N-Methyl-D-aspartic acid (NMDA) in adult zebrafish. We compared the effects of three different NMDA delivery methods on retinal neurodegeneration in adult zebrafish: immersion (I.M.), intravitreal injection (I.V.), and intraperitoneal injection (I.P.)
Gelson Perin et al.
Applied biochemistry and biotechnology, 187(4), 1398-1423 (2018-09-20)
In the present study, the synthesis of new selenoethers from nucleophilic substitution reaction between organyl halides and nucleophilic species of selenium generated in situ was demonstrated. After, this method was applied for the synthesis of pyridylselenides glycerol derivatives 9b and
Management of delayed edema formation after fibrinolytic therapy for intracerebral hematomas: preliminary experimental data.
Rohde V
Acta Neurochirurgica. Supplement, 105, 101-104 (2008)
Vic V Iasnetsov et al.
Eksperimental'naia i klinicheskaia farmakologiia, 76(4), 11-14 (2013-06-15)
It was established that mexidol (100 mg/kg, i.v.) in contrast to cytoflavin (1 ml/kg, i.v.) and reamberin (100 mg/kg, i.v.) produced analgesic effect in rabbits by raising pain threshold under electric stimulation of dental pulp. Mexidol (200 mg/kg, i.p.) also
Elizabeth K Ruzzo et al.
Cell, 178(4), 850-866 (2019-08-10)
We performed a comprehensive assessment of rare inherited variation in autism spectrum disorder (ASD) by analyzing whole-genome sequences of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD risk, including 24 passing genome-wide Bonferroni correction and
Gregory Saia et al.
Journal of neurochemistry, 129(4), 743-752 (2014-01-31)
The regulation of transcription factor function in response to neuronal activity is important for development and function of the nervous system. The transcription factor Sp4 regulates the developmental patterning of dendrites, contributes to complex processes including learning and memory, and
Narayana Pineda-Ramírez et al.
Molecular neurobiology, 57(2), 1055-1069 (2019-11-02)
During cerebral ischemia, oxygen and glucose levels decrease, producing many consequences such as the generation of reactive oxygen species, tissue injury, and the general metabolism collapse. Resveratrol triggers signaling dependent on the protein kinase activated by adenosine monophosphate (AMPK), the
Seojin Hwang et al.
Neurochemical research, 43(12), 2460-2472 (2018-11-15)
Upon synaptic stimulation and glutamate release, glutamate receptors are activated to regulate several downstream effectors and signaling pathways resulting in synaptic modification. One downstream intracellular effect, in particular, is the expression of immediate-early genes (IEGs), which have been proposed to
Hjalte M Larsen et al.
Stem cell research, 41, 101642-101642 (2019-11-11)
The α7 nicotinic acetylcholine receptor has been extensively researched as a target for treatment of cognitive impairment in Alzheimer's disease and schizophrenia. Investigation of the α7 receptor is commonly performed in animals but it is critical to increase the biologically
Chia-Hsueh Lee et al.
Nature, 511(7508), 191-197 (2014-07-11)
N-methyl-d-aspartate (NMDA) receptors are Hebbian-like coincidence detectors, requiring binding of glycine and glutamate in combination with the relief of voltage-dependent magnesium block to open an ion conductive pore across the membrane bilayer. Despite the importance of the NMDA receptor in
S Scheggi et al.
Neuroscience, 109(2), 267-274 (2002-01-22)
The stimulation of glutamate receptors plays a relevant role in the development of behavioral sensitization to psychostimulants, while less clear results have been obtained on their role in morphine sensitization. We addressed this issue by comparing the development of cocaine
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