Showing 1-30 of 62 results for "

M2003

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Christina M A P Schuh et al.
Cells, tissues, organs, 200(5), 287-299 (2015-09-16)
Tissue engineering approaches in nerve regeneration search for ways to support gold standard therapy (autologous nerve grafts) and to improve results by bridging nerve defects with different kinds of conduits. In this study, we describe electrospinning of aligned fibrin-poly(lactic-co-glycolic acid)...
Xuemin Wang et al.
PloS one, 10(4), e0125402-e0125402 (2015-05-01)
Cisplatin is one of the first-line platinum-based chemotherapeutic agents for treatment of many types of cancer, including ovary cancer. CTR1 (copper transporter 1), a transmembrane solute carrier transporter, has previously been shown to increase the cellular uptake and sensitivity of...
Sung Hae Bae et al.
Growth factors (Chur, Switzerland), 33(2), 71-78 (2015-02-26)
l-ascorbic acid 2-phosphate (Asc-2P) acts as an antioxidant and a stimulator of hepatocyte growth factor (HGF) production. Previously, we reported that depletion of growth factors such as fibroblast growth factor (FGF)-2, epidermal growth factor (EGF), FGF-4 and HGF during serial...
Antoine Guillon et al.
Journal of aerosol medicine and pulmonary drug delivery, 28(4), 290-298 (2015-01-24)
Glycopeptides given intravenously achieve low airway concentrations. Nebulization of teicoplanin may be an efficient way of delivering a high concentration of this antibiotic to the lung. This multistep study assessed the feasibility of teicoplanin nebulization during mechanical ventilation by evaluating:...
Kholoud K Khoja et al.
Nutrients, 12(4) (2020-04-16)
Iron deficiency is a global epidemic affecting a third of the world's population. Current efforts are focused on investigating sustainable ways to improve the bioavailability of iron in plant-based diets. Incorporating microgreens into the diet of at-risk groups in populations...
V Z Bergamo et al.
Letters in applied microbiology, 61(5), 504-510 (2015-09-04)
Although the use of catheters in critically ill patients is mostly inevitable, this invasive procedure comes together with several health risks. Within this context, the contamination with Candida tropicalis is a primary concern as this highly prevalent pathogenic yeast can...
Te-chun Hsia et al.
Journal of food science, 80(9), H2094-H2101 (2015-09-16)
Protective effects and actions from s-ethyl cysteine (SEC) and s-methyl cysteine (SMC) for BEAS-2B cells were examined. BEAS-2B cells were pretreated with SEC or SMC at 4, 8, or 16 μmol/L, and followed by hydrogen peroxide (H2 O2 ) treatment....
Seokjo Kang et al.
Cell death discovery, 4, 31-31 (2018-03-14)
Alzheimer's disease (AD) is often characterized by the impairment of mitochondrial function caused by excessive mitochondrial fragmentation. Thrombospondin-1 (TSP-1), which is primarily secreted from astrocytes in the central nervous system (CNS), has been suggested to play a role in synaptogenesis...
Combination treatment with ethyl pyruvate and IGF-I exerts neuroprotective effects against brain injury in a rat model of neonatal hypoxic-ischemic encephalopathy.
Rong Z, et. al.
International Journal of Molecular Medicine, 36, 195-195 (2015)
Roger G Ptak et al.
Antimicrobial agents and chemotherapy, 52(4), 1302-1317 (2008-01-24)
Debio-025 is a synthetic cyclosporine with no immunosuppressive capacity but a high inhibitory potency against cyclophilin A (CypA)-associated cis-trans prolyl isomerase (PPIase) activity. A lack of immunosuppressive effects compared to that of cyclosporine was demonstrated both in vitro and in...
Feng Li et al.
The Prostate, 79(11), 1226-1237 (2019-06-19)
We previously reported the presence of prostate-specific antigen (PSA) in the stromal compartment of benign prostatic hyperplasia (BPH). Since PSA is expressed exclusively by prostatic luminal epithelial cells, PSA in the BPH stroma suggests increased tissue permeability and the compromise...
DJ-1 deficiency triggers microglia sensitivity to dopamine toward a pro-inflammatory phenotype that is attenuated by rasagiline.
Trudler D
Journal of Neurochemistry, 129, 434-434 (2014)
Maria J Bistaffa et al.
Journal of nanoscience and nanotechnology, 20(10), 6180-6190 (2020-05-10)
The photodynamic therapy (PDT) has been outstanding as a promising alternative for treating different carcinomas. However, the lack of detailed knowledge on the mechanisms of action prevents exploitation of the therapy full potential. Herein we shall evaluate not only the...
Zhihui Rong et al.
International journal of molecular medicine, 36(1), 195-203 (2015-05-23)
Neonatal hypoxic-ischemic (HI) brain injury causes severe brain damage in newborns. Following HI injury, rapidly accumulating oxidants injure neurons and interrupt ongoing developmental processes. The antioxidant, sodium pyruvate, has been shown to reduce neuronal injury in neonatal rats under conditions...
Yi-ming Ma et al.
Acta pharmacologica Sinica, 36(4), 517-527 (2015-04-04)
To investigate the effects of physalin B insolated from Physalis divericata on human colon cancer cells in vitro and its anticancer mechanisms. Human HCT116 colon cancer cell line was tested. Cell viability and apoptosis were detected, and relevant proteins were...
Liang Kong et al.
Biological & pharmaceutical bulletin, 38(9), 1290-1301 (2015-09-04)
It is believed that neuronal death caused by abnormal deposition of amyloid-beta peptide is the major cause of the cognitive decline in Alzheimer's disease. Adult neurogenesis plays a key role in the rescue of impaired neurons and amelioration of cognitive...
Che-yi Chao et al.
Journal of the science of food and agriculture, 95(5), 1088-1093 (2014-09-10)
The phytochemical composition of aqueous and ethanol extracts from Gynura bicolor DC., a vegetable, was determined. Human umbilical vein endothelial (HUVE) cells were used to examine the antioxidative and anti-inflammatory potentials of these extracts at 1, 2 or 4% (v/v)...
Yue Hou et al.
Progress in neuro-psychopharmacology & biological psychiatry, 54, 92-102 (2014-04-09)
The present study aims to evaluate the effects of pterostilbene on lipopolysaccharide (LPS)-induced learning and memory impairment as well as the possible changes of microglia and neurons. Firstly, learning and memory function was investigated by behavioral tests. Pterostilbene attenuated LPS-induced...
Weifeng Zhao et al.
Annals of translational medicine, 8(15), 950-950 (2020-09-22)
RACGAP1 has significant involvement in tumorigenesis of cancers, including liver cancer, stomach cancer, and colon cancer. However, the role and the exact mechanism of RACGAP1 in esophageal squamous cell carcinoma (ESCC) has not been explored. QPCR and Western blots analysis...
Mirella B Kobal et al.
Materials science & engineering. C, Materials for biological applications, 112, 110943-110943 (2020-05-16)
Artepillin C is the main compound present in propolis from Baccharis dracunculifolia, whose antitumor activity has been the focus of many studies. Herein, we shall investigate the Artepillin C mechanisms of action against cells derived from the oropharyngeal carcinoma (HEp-2)....
Xiaohui Zhao et al.
Cancer cell international, 20, 51-51 (2020-02-23)
The urgent problem in the treatment of breast cancer is the recurrence induced by breast cancer stem cells (CSCs). Understanding the role and molecular mechanism of specific molecules in breast cancer stem cells can provide a theoretical basis for better...
Stephan Kremb et al.
PloS one, 9(8), e103895-e103895 (2014-08-22)
In recent years, marine algae have emerged as a rich and promising source of molecules with potent activities against various human pathogens. The widely distributed brown alga Lobophora variegata that is often associated with tropical coral reefs exerts strong antibacterial...
Onofrio Zirafi et al.
Science translational medicine, 6(262), 262ra157-262ra157 (2014-11-14)
Topically applied microbicides potently inhibit HIV in vitro but have largely failed to exert protective effects in clinical trials. One possible reason for this discrepancy is that the preclinical testing of microbicides does not faithfully reflect the conditions of HIV...
Eleonora Grisard et al.
EBioMedicine, 46, 79-93 (2019-07-16)
Metastatic colorectal cancer (CRC) remains a deadly disease. Identifying locally advanced CRC patients with high risk of developing metastasis and improving outcome of metastatic CRC patients require discovering master regulators of metastasis. In this context, the non-coding part of the...
Pierre S Leclère et al.
Scientific reports, 10(1), 12139-12139 (2020-07-24)
A large number of hepatic functions are regulated by the circadian clock and recent evidence suggests that clock disruption could be a risk factor for liver complications. The circadian transcription factor Krüppel like factor 10 (KLF10) has been involved in...
Ewa Grela et al.
Avicenna journal of medical biotechnology, 7(4), 159-167 (2015-11-26)
The chromogenic assay based on MTT bioreduction was adapted to Proteus mirabilis viability estimations. We primarily intended to use the assay for the evaluation of novel antimicrobial compounds, including structures with possible permeabilizing activity. Therefore, the influence of basic permeabilizing...
Apei Jiang et al.
Journal of cellular biochemistry, 116(8), 1553-1562 (2015-02-05)
Ubiquitin activating enzyme E1-like (UBE1L) is the activating enzyme for ISG15ylation (ISG15, interferon stimulated gene 15). UBE1L is thought to be a candidate tumor suppressor gene and has positive activity against stress responses such as viral infections. Both type I...
Abimbola O Aro et al.
Phytotherapy research : PTR, 29(7), 1004-1010 (2015-04-11)
Tuberculosis (TB) caused by Mycobacterium tuberculosis remains an ongoing threat to human health. Many plant species contain antimycobacterial compounds, which may serve as template molecules for new anti-TB drugs. The Rubiaceae family is the largest family of trees in southern...
X-R Zhan et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 47(2), 107-113 (2014-09-18)
Diabetic individuals may have elevated levels of serum free fatty acids and may exhibit injury to the vascular endothelial cells. This study was undertaken to determine the relationship between various free fatty acids (FFAs) and vascular endothelial cell injury and...
Yu Sen Hou et al.
Molecular medicine reports, 12(2), 2521-2528 (2015-05-09)
Mesenchymal stem cell (MSC)-based regenerative therapy is currently regarded as a novel approach with which to repair damaged tissues. However, the efficiency of MSC transplantation is limited due to the low survival rate of engrafted MSCs. Lipopolysaccharide (LPS) production is...