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Showing 1-30 of 34 results for "M2265" within Papers
Satyender Rao Valipe et al.
American journal of veterinary research, 72(3), 331-335 (2011-03-02)
To determine antimicrobial effects of caprylic acid and its derivatives, monocaprylin and sodium caprylate, on Dermatophilus congolensis and to determine effects of caprylic acid on the ultrastructure of D congolensis by use of transmission electron microscopy (TEM). 3 strains of
Jingying Liu et al.
International journal of pharmaceutics, 560, 377-384 (2019-02-23)
To face the challenges of oral delivery of peptide and protein (P/P) drugs, self-emulsifying drug delivery systems (SEDDSs) containing monoacyl phosphatidylcholine (MAPC), Labrasol (LAB) and medium-chain (MC) monoglycerides as permeation enhancers (PEs) were evaluated for their effect on intestinal absorption
Cheng Peng et al.
Pharmaceutical development and technology, 23(7), 682-688 (2017-01-28)
Beta-carotene is a potent antioxidant for maintaining human health. However, its oral absorption is low due to poor aqueous solubility of less than 1āĪ¼g/ml. A microemulsion delivery system was designed to solubilize beta-carotene toward enhancing its oral bioavailability. From seven
Gabriela Mojeiko et al.
International journal of pharmaceutics, 560, 365-376 (2019-02-18)
In spite of the high incidence of breast cancer worldwide, there are few strategies for its chemoprevention, and they have limited adherence mainly due to their serious adverse effects. As a new approach for local breast cancer chemoprevention, we developed
Jagruti Desai et al.
Colloids and surfaces. B, Biointerfaces, 175, 143-149 (2018-12-12)
The present work aimed to formulate Darunavir loaded lipid nanoemulsion to increase its oral bioavailability and enhance brain uptake. Various batches of lipid nanoemulsion of Darunavir were prepared by high pressure homogenization using soya bean oil, egg lecithin and Tween
Bindu Ramasahayam et al.
Drug development and industrial pharmacy, 41(5), 753-763 (2014-03-20)
Isradipine (ISR) is a potent calcium channel blocker with low oral bioavailability due to low aqueous solubility, extensive first-pass metabolism and P-glycoprotein (P-gp)-mediated efflux transport. In the present investigation, an attempt was made to develop isradipine-loaded self-nano emulsifying powders (SNEP)
Spandana Inugala et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 74, 1-10 (2015-04-08)
The current study was aimed to investigate the potential of solid self-nanoemulsifying drug delivery system (S-SNEDDS) composed of Capmul MCM C8 (oil), Tween 80 (surfactant) and Transcutol P (co-surfactant) in improving the dissolution and oral bioavailability of darunavir. Liquid self-nanoemulsifying
Neeru Singh et al.
Journal of food science, 85(4), 1223-1230 (2020-03-10)
The present study aims to study the antibacterial activity of food-grade lipidic nanoemulsion (noncationized/cationized) against Bacillus subtilis (BS). Bactericidal activity was ascertained by studying the morphological transitions on BS using transmission electron microscopy (TEM), atomic force microscopy (AFM), and scanning
Katarina Bolko Seljak et al.
Journal of pharmaceutical sciences, 103(11), 3491-3500 (2014-08-12)
A mixed lipid-mixed surfactant self-microemulsifying drug delivery system (SMEDDS) was developed to exploit the health benefits of resveratrol, a Biopharmaceutical Classification System Class 2 natural polyphenol, subject to extensive intestinal presystemic metabolism. SMEDDS with a mixed lipid phase (castor oil/Capmul
Murilo Ferreira de Carvalho et al.
Pharmaceuticals (Basel, Switzerland), 13(4) (2020-04-23)
Carvedilol (CRV) is a non-selective blocker of Ī± and Ī² adrenergic receptors, which has been extensively used for the treatment of hypertension and congestive heart failure. Owing to its poor biopharmaceutical properties, CRV has been incorporated into different types of
Uday Krishna Baruah et al.
Journal of drug targeting, 26(7), 576-591 (2017-10-24)
Chloroquine was once the most widely used antimalarial for nearly eight decades for its safety, efficiency, stability, low cost and finally for its less toxic nature. But its use and efficacy got slowly decreased with the increase of chloroquine resistant
Su-sen Chang et al.
International journal of food microbiology, 144(1), 141-146 (2010-10-12)
Alfalfa and other seed sprouts have been implicated in several Escherichia coli O157:H7 and Salmonella spp. human illness outbreaks in the U.S. Continuing food safety issues with alfalfa seeds necessitate the need for discovery and use of novel and effective
Suhas G Gumaste et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 110, 134-147 (2017-05-17)
Lipid-based self-emulsifying drug delivery systems (SEDDS) are usually liquids, and they can be converted into solid dosage forms by adsorbing onto silicates. However, most commercially available silicates are mesoporous with small pore sizes of 1 to 50nm that lead to
Varun Garg et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 109, 297-315 (2017-08-27)
Development of self-nanoemulsifying drug delivery systems (SNEDDS) of polypeptide-k (PPK) is reported with the aim to achieve its oral delivery. Box-Behnken design (BBD) was adopted to develop and optimize the composition of SNEDDS. Oleoyl polyoxyl-6 glycerides (A), Tween 80 (B)
Abdulsalam M Kassem et al.
Journal of microencapsulation, 34(3), 319-333 (2017-05-10)
The objective of this study was to develop and optimise self-nanoemulsifying drug delivery system (SNEDDS) of atorvastatin calcium (ATC) for improving dissolution rate and eventually oral bioavailability. Ternary phase diagrams were constructed on basis of solubility and emulsification studies. The
Preeti Wavikar et al.
Journal of pharmaceutical sciences, 106(12), 3613-3622 (2017-09-20)
Present investigation explores the potential of nanostructured lipid carriers (NLCs) for nose to brain delivery of rivastigmine (RV), which is further enhanced by incorporating into an in situ gelling system, increasing retention in nasal cavity. NLCs having particle size of
Swati Pund et al.
International journal of pharmaceutics, 487(1-2), 148-156 (2015-04-15)
The present study is a mechanistic validation of 'proof of concept' of effective topical delivery of leflunomide (LFD) nanoemulgel for localized efficient treatment of psoriatic lesions as well as melanoma affected skin regions. Hyperproliferation of keratinocytes in psoriasis and symbiotic
Md Rizwanullah et al.
Journal of drug targeting, 25(1), 58-74 (2016-05-18)
In the present study, rosuvastatin calcium-loaded nanostructured lipid carriers were developed and optimized for improved efficacy. The ROS-Ca-loaded NLC was prepared using melt emulsification ultrasonication technique and optimized by Box-Behnken statistical design. The optimized NLC composed of glyceryl monostearate (solid
Youngseok Ham et al.
SpringerPlus, 5(1), 1526-1526 (2016-09-22)
Biofilm provides a bacterial hiding place by forming a physical barrier and causing physiological changes in cells. The elimination of biofilm is the main goal of hygiene. Chemicals that are inhibitory to biofilm formation have been developed for use in
Kanyaphat Bunchongprasert et al.
International journal of pharmaceutics, 561, 289-295 (2019-03-10)
This study aimed to investigate the following factors affecting the cytotoxicity of CapmulĀ®MCM (C8/10MD) in self-emulsified nanoemulsions (SENs): concentration, triglycerides, and droplet size, and how these factors influence permeability of lipid droplets. Two triglycerides (C8T and C18T) and six formulations
Brian C Seper et al.
Chemistry and physics of lipids, 226, 104833-104833 (2019-11-19)
The densities as a function of temperature of four fully hydrated saturated monoglycerides with even chain lengths ranging from eight to fourteen were determined by vibrating tube densitometry and their phase transition temperatures were determined by differential scanning calorimetry (DSC).
Marilyn Garcia et al.
Journal of food protection, 70(7), 1594-1599 (2007-08-10)
The antilisterial activity of monocaprylin (MC) and its combination with acetic acid (AA) on frankfurters was investigated. Each frankfurter was surface inoculated with a three-strain mixture of Listeria monocytogenes to obtain an inoculation level of 4.0 log CFU per frankfurter
Rohan V Pai et al.
Journal of controlled release : official journal of the Controlled Release Society, 309, 190-202 (2019-07-30)
In recent times, molecular dynamic (MD) simulations have been applied in the area of drug delivery, as an in silico tool to predict the behaviour of nanoparticles with respect to their interaction with larger biological entities like bilayer membranes, DNA
Luis VƔzquez et al.
Frontiers in bioengineering and biotechnology, 4, 6-6 (2016-02-24)
Problems derived from obesity and overweight have recently promoted the development of fat substitutes and other low-calorie foods. On the one hand, fats with short- and medium-chain fatty acids are a source of quick energy, easily hydrolyzable and hardly stored
Dong Jun Shin et al.
Pharmaceutics, 11(2) (2019-02-03)
To improve the dissolution and oral bioavailability of valsartan (VST), we previously formulated a supersaturable self-microemulsifying drug delivery system (SuSMED) composed of CapmulĀ® MCM (oil), TweenĀ® 80 (surfactant), TranscutolĀ® P (cosurfactant), and Poloxamer 407 (precipitation inhibitor) but encountered a stability
Hey-Won Shin et al.
Pharmaceutics, 13(1) (2021-01-10)
This study aims to examine the contribution of nanoporous silica entrapped lipid-drug complexes (NSCs) in improving the solubility and bioavailability of dutasteride (DUT). An NSC was loaded with DUT (dissolved in lipids) and dispersed at a nanoscale level using an
Z MolatovĆ” et al.
Folia microbiologica, 55(3), 215-220 (2010-06-09)
Organic acids can be used as feed supplements or for treatment of poultry carcasses in processing plants. The antimicrobial activity of nineteen organic acids and two monoacylglycerols in cultures of Campylobacter jejuni CCM 6214(T) (ATCC 33560) was determined using a
Jun-Hyung Park et al.
International journal of pharmaceutics, 491(1-2), 393-401 (2015-07-08)
Photodynamic therapy (PDT) is a promising noninvasive treatment modality for cancer. Photosensitizer and specific wave length of light are the key component of PDT. DH-I-180-3, a second generation photosensitizer, was incorporated into lipid nanoparticle for simultaneous fluorescent imaging and targeting
Dong Woo Yeom et al.
Oncotarget, 8(55), 94297-94316 (2017-12-08)
In order to improve the dissolution and oral bioavailability of valsartan (VST), and reduce the required volume for treatment, we previously formulated a supersaturable self-microemulsifying drug delivery system (SuSMEDDS) composed of VST (80 mg), Capmul
Gi-Ho Son et al.
Pharmaceutics, 11(5) (2019-05-11)
Ticagrelor (TGL), a P2Y12 receptor antagonist, is classified as biopharmaceutics classification system (BCS) class IV drug due to its poor solubility and permeability, resulting in low oral bioavailability. Nanostructured lipid carriers (NLC) are an efficient delivery system for the improvement
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