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Ariel Diaz et al.
Journal of cell science, 132(5) (2019-02-03)
Neuronal depolarization induces the synaptic release of tissue-type plasminogen activator (tPA). Cyclin-dependent kinase-5 (Cdk5) is a member of the family of cyclin-dependent kinases that regulates cell migration and synaptic function in postmitotic neurons. Cdk5 is activated by its binding to
Zhe Wei et al.
Molecular neurobiology, 55(8), 6215-6226 (2017-12-29)
Synapse-associated protein 102 (SAP102) is a scaffolding protein highly expressed early in development and plays a critical role in mediating glutamate receptor trafficking during synaptogenesis. Mutations in human SAP102 have been reported to cause intellectual disability, which is thought to
Kelli Lauderdale et al.
ASN neuro, 7(5) (2015-10-23)
Cellular edema (cell swelling) is a principal component of numerous brain disorders including ischemia, cortical spreading depression, hyponatremia, and epilepsy. Cellular edema increases seizure-like activity in vitro and in vivo, largely through nonsynaptic mechanisms attributable to reduction of the extracellular space. However
Atsuki Kawamura et al.
Cell reports, 35(1), 108932-108932 (2021-04-08)
Mutations in the gene encoding the chromatin remodeler chromodomain helicase DNA-binding protein 8 (CHD8) are a highly penetrant risk factor for autism spectrum disorder (ASD). Although cerebellar abnormalities have long been thought to be related to ASD pathogenesis, it has
Raffaella Moretti et al.
Journal of neuroscience research, 94(12), 1546-1560 (2016-10-19)
The cognitive and behavioral deficits caused by traumatic brain injury (TBI) to the immature brain are more severe and persistent than injuries to the adult brain. Understanding this developmental sensitivity is critical because children under 4 years of age of
Joana S Ferreira et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(39), 24526-24533 (2020-09-16)
Hippocampal pyramidal neurons are characterized by a unique arborization subdivided in segregated dendritic domains receiving distinct excitatory synaptic inputs with specific properties and plasticity rules that shape their respective contributions to synaptic integration and action potential firing. Although the basal
Dool-Ri Oh et al.
The American journal of Chinese medicine, 49(1), 69-94 (2020-12-30)
Vaccinium bracteatum Thunb. Leaves (VBL) are a component of traditional herbal medicines. However, molecular mechanisms of VBL in stress-related memory impairment are still unclear. This study aimed to investigate the spatial memory improvement effects of VBL in an animal model
Q-SChick Auh et al.
Muscle & nerve, 56(3), 510-518 (2016-12-16)
N-methyl-d-aspartate (NMDA) is expressed in sensory neurons and plays important roles in peripheral pain mechanisms. The aim of this study was to examine the effects and molecular mechanisms of NMDA on C2C12 myoblast proliferation and differentiation. Cytotoxicity and differentiation were
Dong-Wook Kang et al.
Scientific reports, 6, 37850-37850 (2016-12-03)
We have recently reported that repeated systemic treatments of extract from Corydalis yanhusuo alleviate neuropathic pain and levo-tetrahydropalmatine (l-THP) is one of active components from Corydalis. We designed this study to investigate antinociceptive effect of l-THP in acute and chronic
J I Nagy et al.
Neuroscience, 384, 241-261 (2018-06-08)
Intimate structural and functional relationships between gap junctions and adherens junctions have been demonstrated in peripheral tissues, but have not been thoroughly examined in the central nervous system, where adherens junctions are often found in close proximity to neuronal gap
Vsevolod Telezhkin et al.
American journal of physiology. Cell physiology, 310(7), C520-C541 (2016-01-01)
Although numerous protocols have been developed for differentiation of neurons from a variety of pluripotent stem cells, most have concentrated on being able to specify effectively appropriate neuronal subtypes and few have been designed to enhance or accelerate functional maturity.
Yue Yang et al.
Neurochemical research, 45(11), 2703-2711 (2020-09-07)
Kukoamine (KuA) is a spermine alkaloid present in traditional Chinese medicine Cortex Lycii radices, which possesses various pharmacological properties. Our previous studies have demonstrated that KuA exerts neuroprotective effects against H2O2-induced oxidative stress, radiation-induced neuroinflammation, oxidative stress and neuronal apoptosis
Tasha Ahmad et al.
Addiction biology, 22(5), 1218-1231 (2016-05-28)
Functional connections between the basolateral amygdala (BLA) and nucleus accumbens (NAc) are involved critically in opiate-reward processing. In the BLA, inhibitory GABAergic substrates are inhibited by cannabinoid CB1 receptor (CB1R) activation and can modulate BLA projections to various limbic regions
Ruth Drdla-Schutting et al.
Pain, 160(12), 2819-2828 (2019-08-23)
Opioids are the most powerful analgesics available to date. However, they may also induce adverse effects including paradoxical opioid-induced hyperalgesia. A mechanism that might underlie opioid-induced hyperalgesia is the amplification of synaptic strength at spinal C-fibre synapses after withdrawal from
Sang Hun Lee et al.
Neuron, 108(4), 676-690 (2020-09-07)
Amyloid precursor protein (APP) is associated with both familial and sporadic forms of Alzheimer's disease. Despite its importance, the role of APP family in neuronal function and survival remains unclear because of perinatal lethality exhibited by knockout mice lacking all
Glauber S F da Silva et al.
Frontiers in physiology, 8, 452-452 (2017-07-18)
Hydrogen Sulfide (H
Erica Sequeira et al.
Marine drugs, 18(7) (2020-07-28)
Emerging literature suggests that after a stroke, the peri-infarct region exhibits dynamic changes in excitability. In rodent stroke models, treatments that enhance excitability in the peri-infarct cerebral cortex promote motor recovery. This increase in cortical excitability and plasticity is opposed
F Fonnum et al.
Journal of neurochemistry, 88(3), 513-531 (2004-01-15)
Six chemicals, 2-halopropionic acids, thiophene, methylhalides, methylmercury, methylazoxymethanol (MAM) and trichlorfon (Fig. 1), that cause selective necrosis to the cerebellum, in particular to cerebellar granule cells, have been reviewed. The basis for the selective toxicity to these neurones is not
Protease-activated receptor 1 (PAR1) inhibits synaptic NMDARs in mouse nigral dopaminergic neurons.
Price, et al.
Pharmacological Research, 160, 105185-105185 (2020)
Charalambos Kaittanis et al.
The Journal of experimental medicine, 215(1), 159-175 (2017-11-17)
Prostate-specific membrane antigen (PSMA) or folate hydrolase 1 (FOLH1) is highly expressed on prostate cancer. Its expression correlates inversely with survival and increases with tumor grade. However, the biological role of PSMA has not been explored, and its role in
Takahiro Kurose et al.
International journal of ophthalmology, 12(8), 1231-1237 (2019-08-29)
To evaluate the neuroprotective effect of a dietary supplement (ClearVision EX®; CV) against glutamate-induced excitotoxicity in retina. We evaluated the protective effects CV on glutamate-induced cell toxicity of an immortalized mouse hippocampal cell line (HT-22) in vitro and N-methyl-D-aspartate (NMDA)
Maria Mancini et al.
Pharmacological research, 87, 80-86 (2014-06-29)
In the present study, the neuroprotective effects of the adipokine leptin, and the molecular mechanism involved, have been studied in rat and mice cortical neurons exposed to N-methyl-d-aspartate (NMDA) in vitro. In rat cortical neurons, leptin elicited neuroprotective effects against
Max L Mehlman et al.
Journal of neurophysiology, 121(2), 350-370 (2018-11-15)
Head direction (HD) cells fire as a function of the animal's directional heading and provide the animal with a sense of direction. In rodents, these neurons are located primarily within the limbic system, but small populations of HD cells are
Machi Kuroda et al.
Neuroreport, 31(6), 478-483 (2020-03-14)
Progranulin (PGRN) is a glycoprotein that is widely expressed among organs, including the central nervous system. PGRN insufficiency is involved in various neurodegenerative disorders such as frontotemporal dementia, Alzheimer's disease, and neuronal ceroid lipofuscinosis. One of the major causes of
Kun Zeng et al.
Oncotarget, 8(39), 65009-65021 (2017-10-17)
We investigated the effects of lentivirus-mediated RNAi targeting of Nogo Receptor (
Robert F Miller
Glia, 47(3), 275-283 (2004-07-15)
Until the last decade, it was widely accepted that D-amino acids had no functional role in higher organisms, but that they were restricted to lower organisms, such as bacteria, where they are integrated into the proteoglycans of the cell wall.
Anett Schumacher et al.
Hippocampus, 26(4), 530-542 (2015-10-24)
The resolution of an approach-avoidance conflict induced by ambivalent information involves the appraisal of the incentive value of the outcomes and associated stimuli to orchestrate an appropriate behavioral response. Much research has been directed at delineating the neural circuitry underlying
Muhammad Fattah Fazel et al.
PloS one, 15(7), e0236450-e0236450 (2020-07-25)
Retinal ganglion cell (RGC) loss and optic neuropathy, both hallmarks of glaucoma, have been shown to involve N-methyl-D-aspartate receptor (NMDAR)-mediated excitotoxicity. This study investigated the neuroprotective effects of Philanthotoxin (PhTX)-343 in NMDA-induced retinal injury to alleviate ensuing visual impairments. Sprague-Dawley
Tamara Coslovich et al.
Journal of neuroscience research, 96(5), 889-900 (2017-11-09)
Spinal motoneurons and locomotor networks are regulated by monoamines, among which, the contribution of histamine has yet to be fully addressed. The present study investigates histaminergic regulation of spinal activity, combining intra- and extracellular electrophysiological recordings from neonatal rat spinal
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