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Xi Zhan et al.
Pharmaceutical research, 32(7), 2280-2291 (2015-01-17)
A key step of delivering extracellular agents to its intracellular target is to escape from endosomal/lysosomal compartments, while minimizing the release of digestive enzymes that may compromise cellular functions. In this study, we examined the intracellular distribution of both fluorecent
Frans J Smit et al.
European journal of medicinal chemistry, 90, 33-44 (2014-12-03)
A series of dihydroartemisinyl-chalcone esters were synthesized through esterification of chalcones with dihydroartemisinin (DHA). The hybrids were screened against chloroquine (CQ) sensitive (3D7) and CQ resistant (W2) strains of intraerythrocytic Plasmodium falciparum parasites, and were all found to be active
Zelene Edith Vázquez-Zamorano et al.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 27(4), 683-693 (2014-06-19)
Streptococcus pneumoniae is a gram positive encapsulated bacterium responsible of septicaemia and upper respiratory infections in children. This pathogen requires iron to survive in the host, which it can obtain of haemoglobin (Hb) or haem. Only two Hb-binding membrane proteins
D R Scott et al.
Alimentary pharmacology & therapeutics, 42(11-12), 1315-1326 (2015-10-02)
The gastric H(+) ,K(+) -ATPase is the preferred target for acid suppression. Until recently, the only drugs that effectively inhibited this ATPase were the proton pump inhibitors (PPIs). PPIs are acid-activated prodrugs that require acid protection. Once acid-activated, PPIs bind
Nidhi B Panda et al.
Journal of clinical anesthesia, 25(2), 92-97 (2013-01-22)
To study the minimal effective dose of magnesium sulfate to control blood pressure (BP) during intubation in hypertensive patients. Prospective, randomized, double-blind study. Operating room of an academic medical center. 80 adult, ASA physical status 1 and 2, controlled hypertensive
Naoki Tanigawa et al.
PloS one, 9(11), e113345-e113345 (2014-11-19)
Polymerase chain reaction (PCR) amplification of multiple templates using common primers is used in a wide variety of molecular biological techniques. However, abundant templates sometimes obscure the amplification of minor species containing the same primer sequences. To overcome this challenge
Zdenka Veprikova et al.
Journal of agricultural and food chemistry, 63(29), 6633-6643 (2015-07-15)
Mycotoxin contamination of dietary supplements represents a possible risk for human health, especially in the case of products intended for people suffering from certain health conditions. The aim of this study was to assess the extent of this problem based
Pau Calatayud-Vernich et al.
The Science of the total environment, 541, 33-41 (2015-09-24)
Samples of dead honey bees (Apis mellifera L.) were collected periodically from 4 different locations during citrus and stone fruit trees blooming season to evaluate the potential impact of agrochemicals on honey bee death rate. For the determination of mortality
Qin-Hua Gu et al.
Nature communications, 6, 6789-6789 (2015-04-11)
Long-term potentiation (LTP) is a form of synaptic plasticity that results in enhanced synaptic strength. It is associated with the formation and enlargement of dendritic spines-tiny protrusions accommodating excitatory synapses. Both LTP and spine remodelling are crucial for brain development
Feng An et al.
PloS one, 10(4), e0125595-e0125595 (2015-05-01)
Rubber tree (Hevea brasiliensis) latex, the source of natural rubber, is synthesised in the cytoplasm of laticifers. Efficient water inflow into laticifers is crucial for latex flow and production since it is the determinant of the total solid content of
Padhmanand Sudhakar et al.
BMC genomics, 15, 362-362 (2014-06-03)
Carolacton is a newly identified secondary metabolite causing altered cell morphology and death of Streptococcus mutans biofilm cells. To unravel key regulators mediating these effects, the transcriptional regulatory response network of S. mutans biofilms upon carolacton treatment was constructed and
Saranya Plaon et al.
Journal of aquatic animal health, 27(3), 156-163 (2015-07-30)
Vibrio alginolyticus is a major bacterial pathogen causing disease in marine animals. The present study aimed to develop a loop-mediated isothermal amplification (LAMP) coupled with a lateral flow dipstick (LFD) for rapid and simple visual detection of V. alginolyticus-specific amplicons.
D M Al-Mailem et al.
Canadian journal of microbiology, 59(12), 837-844 (2013-12-10)
Ten hydrocarbonoclastic halobacterial species and 5 haloarchaeal species that had been isolated on a mineral medium with oil as the sole carbon source grew better and consumed more crude oil, as measured by gas-liquid chromatography, in media receiving between 0.50
Jamilu Tukur et al.
Maternal and child health journal, 17(7), 1191-1198 (2012-09-08)
The aim of this study was to evaluate whether a new low-cost strategy for the introduction of magnesium sulphate (MgSO4) for preeclampsia and eclampsia in low-resource areas will result in improved maternal and perinatal outcomes. Doctors and midwives from ten
Brooke Morriswood et al.
Eukaryotic cell, 14(11), 1081-1093 (2015-09-01)
The parasite Trypanosoma brucei lives in the bloodstream of infected mammalian hosts, fully exposed to the adaptive immune system. It relies on a very high rate of endocytosis to clear bound antibodies from its cell surface. All endo- and exocytosis
Woo-Yong Lee et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(38), 13936-13941 (2014-09-11)
CXCR6-GFP(+) cells, which encompass 70% invariant natural killer T cells (iNKT cells), have been found primarily patrolling inside blood vessels in the liver. Although the iNKT cells fail to interact with live pathogens, they do respond to bacterial glycolipids presented
M Javier Herrero-Turrión et al.
BMC genomics, 15, 874-874 (2014-10-09)
A great number of studies have investigated changes induced by morphine exposure in gene expression using several experimental models. In this study, we examined gene expression changes during chronic exposure to morphine during maturation and differentiation of zebrafish CNS. Microarray
Sumihiro Koyama et al.
Marine biotechnology (New York, N.Y.), 17(5), 678-692 (2015-08-06)
The purpose of this study was to develop a novel electrical retrieval method (ER method) for living sponge-associated microorganisms from marine sponges frozen at -80 °C. A -0.3-V vs. Ag/AgCl constant potential applied for 2 h at 9 °C induced
Fuchao Xu et al.
Journal of chromatography. A, 1401, 33-41 (2015-05-23)
A multi-residue analytical method was developed for the determination of a range of flame retardants (FRs), including polybrominated diphenyl ethers (PBDEs), emerging halogenated FRs (EFRs) and organophosphate FRs (PFRs), in food matrices. An ultrasonication and vacuum assisted extraction (UVAE), followed
D H Currie et al.
Applied and environmental microbiology, 80(16), 5001-5011 (2014-06-08)
Thermoanaerobacterium saccharolyticum, a Gram-positive thermophilic anaerobic bacterium, grows robustly on insoluble hemicellulose, which requires a specialized suite of secreted and transmembrane proteins. We report here the characterization of proteins secreted by this organism. Cultures were grown on hemicellulose, glucose, xylose
Afrouz Yousefi et al.
Pharmaceutical research, 31(11), 3127-3135 (2014-05-21)
Since the discovery of RNAi and its therapeutic potential, carrier systems have been developed to deliver small RNAs (particularly siRNA) for modulation of gene expression at the post-transcriptional level. An important factor determining the fate and usability of these systems
José F Huertas-Pérez et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 32(8), 1352-1357 (2015-07-01)
A rapid, simple and effective method for the determination of citrinin in rice by UHPLC coupled to fluorescence detection has been developed and validated. Extraction of citrinin from rice samples was achieved by applying a QuEChERS-based extraction/partitioning process with water
Lilia C De Jesus et al.
American journal of obstetrics and gynecology, 212(1), 94-94 (2014-07-22)
Antenatal magnesium (anteMg) is used for various obstetric indications including fetal neuroprotection. Infants exposed to anteMg may be at risk for respiratory depression and delivery room (DR) resuscitation. The study objective was to compare the risk of acute cardiorespiratory events
Robert J Floor et al.
Chembiochem : a European journal of chemical biology, 15(11), 1660-1672 (2014-07-01)
We explored the use of a computational design framework for the stabilization of the haloalkane dehalogenase LinB. Energy calculations, disulfide bond design, molecular dynamics simulations, and rational inspection of mutant structures predicted many stabilizing mutations. Screening of these in small
Agustín Conde-Agudelo et al.
American journal of obstetrics and gynecology, 209(6), 551-551 (2013-07-31)
The purpose of this study was to evaluate the efficacy and safety of transdermal nitroglycerin as a tocolytic agent in women with preterm labor. We conducted a systematic review and metaanalysis of randomized controlled trials. Thirteen studies were included (1302
Masahiro Watanabe et al.
AMB Express, 4, 27-27 (2014-06-21)
Cellulosic materials constitute most of the biomass on earth, and can be converted into biofuel or bio-based materials if fermentable sugars can be released using cellulose-related enzymes. Acremonium cellulolyticus is a mesophilic fungus which produces a high amount of cellulose-related
Caroline A Crowther et al.
The Cochrane database of systematic reviews, 8(8), CD001060-CD001060 (2014-08-16)
Magnesium sulphate has been used in some settings as a tocolytic agent to inhibit uterine activity in women in preterm labour with the aim of preventing preterm birth. To assess the effects of magnesium sulphate therapy given to women in
Hiromi Murase et al.
Investigative ophthalmology & visual science, 56(4), 2511-2518 (2015-03-26)
Renewal and elimination of the aged photoreceptor outer segment (POS) by RPE cells is a daily rhythmic process that is important for long-term vision. Phagocytic dysfunction results in photoreceptor cell death. Tauroursodeoxycholic acid (TUDCA), an endogenous bile acid, is known
Daniel J Modulevsky et al.
PloS one, 9(5), e97835-e97835 (2014-05-21)
There are numerous approaches for producing natural and synthetic 3D scaffolds that support the proliferation of mammalian cells. 3D scaffolds better represent the natural cellular microenvironment and have many potential applications in vitro and in vivo. Here, we demonstrate that
Gabriele Fluhr et al.
BMC gastroenterology, 13, 11-11 (2013-01-17)
Acute pancreatitis is the most common complication of diagnostic and therapeutic endoscopic retrograde cholangiopancreatography (ERCP). In spite of continuing research, no pharmacologic agent capable of effectively reducing the incidence of ERCP-induced pancreatitis has found its way into clinical practise. A
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