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Guenhaël Sanz et al.
PloS one, 9(1), e85110-e85110 (2014-01-15)
Olfactory receptors (ORs) are expressed in the olfactory epithelium, where they detect odorants, but also in other tissues with additional functions. Some ORs are even overexpressed in tumor cells. In this study, we identified ORs expressed in enterochromaffin tumor cells...
Benjamin Grau et al.
Purinergic signalling, 4(4), 357-364 (2008-09-09)
The formation of appropriate connections between neurons and their specific targets is an essential step during development and repair of the nervous system. Growth cones are located at the leading edges of the growing neurites and respond to environmental cues...
Irene A van Dijk et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(8), 3124-3132 (2015-04-24)
Histatins (Hsts) are histidine-rich peptides exclusively present in the saliva of higher primates. In this study, we explored the effects of Hsts on cell-substrate and cell-cell adhesion. Histatin (Hst)-1 caused a significant (>2-fold) increase (EC50 = 1 µM) in the...
Ali S Hamodi et al.
eLife, 9 (2020-05-19)
Convenient, efficient and fast whole-brain delivery of transgenes presents a persistent experimental challenge in neuroscience. Recent advances demonstrate whole-brain gene delivery by retro-orbital injection of virus, but slow and sparse expression and the large injection volumes required make this approach...
Ram Hari Dahal et al.
Antioxidants (Basel, Switzerland), 9(4) (2020-04-01)
Various cosmetics having a single function are increasingly being used, but cosmetics having multifunctional activities remain limited. We aimed to develop a multifunctional cosmetic cream having antioxidant, anti-tyrosinase, anti-aging and antimicrobial activities. Antimicrobial activities were performed by disc-diffusion method. Cell...
Neuroserpin Portland (Ser52Arg) is trapped as an inactive intermediate that rapidly forms polymers: implications for the epilepsy seen in the dementia FENIB
Belorgey D, et al.
European Journal of Biochemistry, 271(16), 3360-3367 (2004)
Angela Rouyar et al.
PloS one, 6(10), e26443-e26443 (2011-10-27)
In nature the aerial trace of pheromone used by male moths to find a female appears as a train of discontinuous pulses separated by gaps among a complex odorant background constituted of plant volatiles. We investigated the effect of such...
Takeshi Itabashi et al.
Nature methods, 6(2), 167-172 (2009-01-20)
Accurate chromosome segregation during meiosis depends on the assembly of a microtubule-based spindle of proper shape and size. Current models for spindle-size control focus on reaction diffusion-based chemical regulation and balance in activities of motor proteins. Although several molecular perturbations...
Etienne Loiseau et al.
Science advances, 2(4), e1500465-e1500465 (2016-05-07)
Morphological transformations of living cells, such as shape adaptation to external stimuli, blebbing, invagination, or tethering, result from an intricate interplay between the plasma membrane and its underlying cytoskeleton, where molecular motors generate forces. Cellular complexity defies a clear identification...
Kondababu Kurakula et al.
PloS one, 9(4), e94931-e94931 (2014-04-17)
The LIM-only protein FHL2, also known as DRAL or SLIM3, has a function in fine-tuning multiple physiological processes. FHL2 is expressed in the vessel wall in smooth muscle cells (SMCs) and endothelial cells and conflicting data have been reported on...
Alessia Mastrodonato et al.
Scientific reports, 8(1), 262-262 (2018-01-13)
Exposure to extremely low-frequency electromagnetic fields (ELFEF) influences the expression of key target genes controlling adult neurogenesis and modulates hippocampus-dependent memory. Here, we assayed whether ELFEF stimulation affects olfactory memory by modulating neurogenesis in the subventricular zone (SVZ) of the...
Katharina Dürre et al.
Nature communications, 9(1), 1630-1630 (2018-04-25)
Arp2/3 complex-mediated actin assembly at cell membranes drives the formation of protrusions or endocytic vesicles. To identify the mechanism by which different membrane deformations can be achieved, we reconstitute the basic membrane deformation modes of inward and outward bending in...
S Dhawan et al.
Acta physiologica (Oxford, England), 213(4), 846-859 (2015-02-17)
Various types of cholinergic receptors are expressed on intestinal epithelia. Their function is not completely understood. We hypothesize that cholinergic receptor activation on epithelium may serve a protective function in cytokine-induced barrier dysfunction. The effect of cholinergic receptor activation on...
Marie-Laure Volvert et al.
BMC pharmacology, 8, 10-10 (2008-06-14)
Lipid-soluble thiamine precursors have a much higher bioavailability than genuine thiamine and therefore are more suitable for therapeutic purposes. Benfotiamine (S-benzoylthiamine O-monophosphate), an amphiphilic S-acyl thiamine derivative, prevents the progression of diabetic complications, probably by increasing tissue levels of thiamine...
Lynda K McGinnis et al.
Developmental biology, 327(2), 280-287 (2009-01-03)
Oocyte maturation invokes complex signaling pathways to achieve cytoplasmic and nuclear competencies for fertilization and development. The Src-family kinases FYN, YES and SRC are expressed in mammalian oocytes but their function during oocyte maturation remains an open question. Using chemical...
Xuchu Ma et al.
Dalton transactions (Cambridge, England : 2003), (46)(46), 10250-10255 (2009-11-19)
Na(4)Si(4) and Na(4)Ge(4) are ideal chemical precursors for inorganic clathrate structures, clusters, and nanocrystals. The monoclinic Zintl phases, Na(4)Si(4) and Na(4)Ge(4), contain isolated homo-tetrahedranide [Si(4)](4-) and [Ge(4)](4-) clusters surrounded by alkali metal cations. In this study, a simple scalable route...
Elisabetta Sabini et al.
Journal of molecular biology, 378(3), 607-621 (2008-04-02)
Deoxycytidine kinase (dCK) is an essential nucleoside kinase critical for the production of nucleotide precursors for DNA synthesis. This enzyme catalyzes the initial conversion of the nucleosides deoxyadenosine (dA), deoxyguanosine (dG), and deoxycytidine (dC) into their monophosphate forms, with subsequent...
Hye Jin Kim et al.
Clinical and experimental reproductive medicine, 42(3), 94-100 (2015-10-17)
The goal of this study was to ascertain optimal assisted hatching (AH) method in frozen embryo transfer. We compared the effect of depending on whether mechanical or laser-AH was performed before or after the vitrification of embryo development rate and...
J Deek et al.
Soft matter, 14(10), 1897-1902 (2018-02-22)
Although cytoskeletal networks are interpenetrating and interacting in living cells, very little is understood as to the effect their interaction has on their properties. Here, as a step towards elucidating the synergistic cellular role of these structural proteins, we investigate...
Petra Kellers et al.
Acta crystallographica. Section F, Structural biology and crystallization communications, 64(Pt 8), 719-722 (2008-08-06)
The membrane-bound [NiFe] hydrogenase is a unique metalloprotein that is able to catalyze the reversible oxidation of hydrogen to protons and electrons during a complex reaction cycle. The [NiFe] hydrogenase was isolated from the photosynthetic purple sulfur bacterium Allochromatium vinosum...
Catherine Rouby et al.
International journal of otolaryngology, 2011, 203805-203805 (2011-11-03)
The LCOT is a self-administered test designed to assess olfactory deficits. Altogether, 525 subjects contributed to the validation. Elderly participants were well represented in this sample. In a validation study (study 1), 407 healthy and 17 anosmic volunteers between 15...
Intraspecific variation of Rhizoctonia solani AG 3 isolates recovered from potato fields in Central Iran and South Australia
Balali GR, et al.
Mycopathologia, 163(2), 105-115 (2007)
Shai Kaplan et al.
Molecular cell, 29(6), 786-792 (2008-04-01)
Cells respond to signals by regulating gene expression. The relation between the level of input signals and the transcription rate of the gene is called the gene's input function. Because most genes are regulated by more than one signal, the...
Alexander D Graham et al.
Biofabrication, 12(1), 015018-015018 (2019-11-13)
Adipose models have been applied to mechanistic studies of metabolic diseases (such as diabetes) and the subsequent discovery of new therapeutics. However, typical models are either insufficiently complex (2D cell cultures) or expensive and labor intensive (mice/in vivo). To bridge...
Tomoko Watanabe et al.
BMC cell biology, 11, 38-38 (2010-06-08)
Lipid droplets (LD) are organelles with an important role in normal metabolism and disease. The lipid content of embryos has a major impact on viability and development. LD in Drosophila embryos and cultured cell lines have been shown to move...
Zida Li et al.
Biomicrofluidics, 13(2), 024112-024112 (2019-05-09)
Removing volumes from droplets is a challenging but critical step in many droplet-based applications. Geometry-mediated droplet splitting has the potential to reliably divide droplets and thus facilitate the implementation of this step. In this paper, we report the design of...
A review on the extensive skin benefits of mineral oil
Rawlings AV and Lombard KJ
International Journal of Cosmetic Science, 34(6), 511-518 (2012)
Bart E Vos et al.
Acta biomaterialia, 104, 39-52 (2020-01-11)
Fibrin is an elastomeric protein forming highly extensible fiber networks that provide the scaffold of blood clots. Here we reveal the molecular mechanisms that explain the large extensibility of fibrin networks by performing in situ small angle X-ray scattering measurements...
Matthew D Dean et al.
Evolution; international journal of organic evolution, 63(1), 20-28 (2008-08-30)
Barriers to gene flow can arise at any stage in the reproductive sequence. Most studies of reproductive isolation focus on premating or postzygotic phenotypes, leaving the importance of differences in fertilization rate overlooked. Two closely related species of house mice...
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