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Esther de Jong et al.
Toxicology and applied pharmacology, 253(2), 103-111 (2011-03-30)
The relatively high experimental animal use in developmental toxicity testing has stimulated the search for alternatives that are less animal intensive. Three widely studied alternative assays are the mouse Embryonic Stem cell Test (EST), the Zebrafish Embryotoxicity Test (ZET) and...
Brigette Y Monroy et al.
Developmental cell, 53(1), 60-72 (2020-02-29)
Many eukaryotic cells distribute their intracellular components asymmetrically through regulated active transport driven by molecular motors along microtubule tracks. While intrinsic and extrinsic regulation of motor activity exists, what governs the overall distribution of activated motor-cargo complexes within cells remains...
Joseph A Fantuzzo et al.
Technology, 5(2), 87-97 (2017-08-07)
Neurocircuits in the human brain govern complex behavior and involve connections from many different neuronal subtypes from different brain regions. Recent advances in stem cell biology have enabled the derivation of patient-specific human neuronal cells of various subtypes for the...
Xiang Li et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(3), 4764-4782 (2020-02-07)
Damage or degeneration of inner ear spiral ganglion neurons (SGNs) causes hearing impairment. Previous in vitro studies indicate that cochlear glial cells can be reprogrammed into SGNs, however, it remains unknown whether this can occur in vivo. Here, we show...
Nicolas Broguiere et al.
Biomaterials, 99, 47-55 (2016-05-23)
Hyaluronan (HA) is an essential component of the central nervous system's extracellular matrix and its high molecular weight (MW) form has anti-inflammatory and anti-fibrotic properties relevant for regenerative medicine. Here, we introduce a new hydrogel based on high MW HA...
Sabina Eigenbrod et al.
Acta neurochirurgica, 156(8), 1427-1440 (2014-05-06)
In gliomas molecular biomarkers are increasingly gaining diagnostic, prognostic and predictive significance. Determination of biomarker status after biopsy is important as not all patients are eligible for open tumor resection. We developed and validated prospectively (6/10-12/11) a protocol allowing for...
Laurie H Sanders et al.
Neurobiology of disease, 70, 214-223 (2014-07-02)
DNA damage can cause (and result from) oxidative stress and mitochondrial impairment, both of which are implicated in the pathogenesis of Parkinson's disease (PD). We therefore examined the role of mitochondrial DNA (mtDNA) damage in human postmortem brain tissue and...
Tatyana Kanyshkova et al.
Molecular and cellular neurosciences, 61, 110-122 (2014-06-11)
The polygenic origin of generalized absence epilepsy results in dysfunction of ion channels that allows the switch from physiological asynchronous to pathophysiological highly synchronous network activity. Evidence from rat and mouse models of absence epilepsy indicates that altered Ca(2+) channel...
Sajal Afzal et al.
Marine drugs, 17(3) (2019-03-27)
Stress, protein aggregation, and loss of functional properties of cells have been shown to contribute to several deleterious pathologies including cancer and neurodegeneration. The incidence of these pathologies has also been shown to increase with age and are often presented...
Wen Zhang et al.
Molecular medicine reports, 13(5), 4357-4364 (2016-04-08)
Chemotactic cytokines (chemokines) are a highly conserved class of secreted signaling molecules that are important in various cellular processes. CXC chemokine ligand 12 (CXCL12) and its receptor, CXC chemokine receptor 4 (CXCR4) have been previously reported to be crucial for the establishment...
Morphological changes of cortical and hippocampal neurons after treatment with VEGF and bevacizumab.
Latzer P, et al.
CNS Neuroscience & Therapeutics, 22(6), 440-450 (2016)
Sukant Garg et al.
Annals of neurosciences, 25(4), 201-209 (2019-04-20)
Natural extracts and compounds used in traditional home medicine are known for their safety and a variety of health promoting and therapeutic potentials. In contrast to the single molecule mediated targets, the combinational therapies are preferred for their multi-functional and...
Chrystian J Alves et al.
Frontiers in cellular neuroscience, 9, 289-289 (2015-08-25)
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease that leads to widespread motor neuron death, general palsy and respiratory failure. The most prevalent sporadic ALS form is not genetically inherited. Attempts to translate therapeutic strategies have failed because the...
Qinghai Liu et al.
PloS one, 11(4), e0153376-e0153376 (2016-04-14)
This study examines the effects of nano-size particulate matter (nPM) exposure in the setting of murine reperfused stroke. Particulate matter is a potent source of inflammation and oxidative stress. These processes are known to influence stroke progression through recruitment of...
Stephanie May et al.
Acta neuropathologica, 128(4), 485-503 (2014-08-15)
Hexanucleotide repeat expansion in C9orf72 is the most common pathogenic mutation in patients with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Despite the lack of an ATG start codon, the repeat expansion is translated in all reading frames...
Xiaoqin Jiang et al.
Molecular medicine reports, 18(5), 4595-4602 (2018-09-18)
Hypoxic‑ischemic encephalopathy is one of the most notable causes of brain injury in newborns. Cerebral ischemia and reperfusion lead to neuronal damage and neurological disability. In vitro and in vivo analyses have indicated that E3 ubiquitin protein ligase (Huwe1) is important for...
Kyung Sik Yi et al.
Journal of neuroscience methods, 344, 108838-108838 (2020-07-04)
The study aimed to establish a staining method that could delineate the macroscopic lesion boundary of a hyperacute infarction depicted by diffusion-weighted MRI (DWI) and to validate the infarction boundary by comparing different staining methods. Thirteen rats with 1 -h middle...
Fabienne C Fiesel et al.
EMBO reports, 16(9), 1114-1130 (2015-07-15)
Mutations in PINK1 and PARKIN cause recessive, early-onset Parkinson's disease (PD). Together, these two proteins orchestrate a protective mitophagic response that ensures the safe disposal of damaged mitochondria. The kinase PINK1 phosphorylates ubiquitin (Ub) at the conserved residue S65, in...
Leif Dehmelt et al.
Genome biology, 6(1), 204-204 (2005-01-12)
Microtubule-associated proteins (MAPs) of the MAP2/Tau family include the vertebrate proteins MAP2, MAP4, and Tau and homologs in other animals. All three vertebrate members of the family have alternative splice forms; all isoforms share a conserved carboxy-terminal domain containing microtubule-binding...
Joséphine Lantoine et al.
Biomaterials, 89, 14-24 (2016-03-08)
The ability to construct easily in vitro networks of primary neurons organized with imposed topologies is required for neural tissue engineering as well as for the development of neuronal interfaces with desirable characteristics. However, accumulating evidence suggests that the mechanical properties...
E Collyer et al.
Experimental neurology, 261, 451-461 (2014-08-01)
After an incomplete spinal cord injury (SCI), partial recovery of locomotion is accomplished with time. Previous studies have established a functional link between extension of axon collaterals from spared spinal tracts and locomotor recovery after SCI, but the tissular signals...
Jing Chen et al.
PloS one, 9(3), e91680-e91680 (2014-03-13)
Multiple organ systems, including the brain, which undergoes changes that may increase the risk of cognitive decline, are adversely affected by diabetes mellitus (DM). Here, we demonstrate that type 2 diabetes mellitus (T2DM) db/db mice exhibited hippocampus-dependent memory impairment, which...
Rouhollah Habibey et al.
Scientific reports, 7(1), 8558-8558 (2017-08-19)
Due to their small dimensions, electrophysiology on thin and intricate axonal branches in support of understanding their role in normal and diseased brain function poses experimental challenges. To reduce experimental complexity, we coupled microelectrode arrays (MEAs) to bi-level microchannel devices...
Pascal Röderer et al.
Molecular neurobiology, 55(11), 8414-8424 (2018-03-20)
Amyotrophic lateral sclerosis is a devastating motor neuron disease and to this day not curable. While 5-10% of patients inherit the disease (familiar ALS), up to 95% of patients are diagnosed with the sporadic form (sALS). ALS is characterized by...
Nari Hong et al.
Nature communications, 11(1), 6313-6313 (2020-12-11)
Cultured neuronal networks with a controlled structure have been widely studied as an in vitro model system to investigate the relationship between network structure and function. However, most cell culture techniques lack the ability to control network structures during cell...
Chao Li et al.
eLife, 9 (2020-01-09)
Inner ear cochlear spiral ganglion neurons (SGNs) transmit sound information to the brainstem. Recent single cell RNA-Seq studies have revealed heterogeneities within SGNs. Nonetheless, much remains unknown about the transcriptome of SGNs, especially which genes are specifically expressed in SGNs....
Przemysław Duda et al.
International journal of molecular sciences, 22(9) (2021-05-06)
Fructose 1,6-bisphosphatase 2 (Fbp2) is a gluconeogenic enzyme and multifunctional protein modulating mitochondrial function and synaptic plasticity via protein-protein interactions. The ability of Fbp2 to bind to its cellular partners depends on a quaternary arrangement of the protein. NAD+ and...
Apoorva Halikere et al.
Molecular psychiatry, 25(7), 1406-1419 (2019-09-05)
The OPRM1 A118G single nucleotide polymorphism (SNP rs1799971) gene variant encoding the N40D µ-opioid receptor (MOR) has been associated with dependence on opiates and other drugs of abuse but its mechanism is unknown. The frequency of G-allele carriers is ~40%...
Molecular analysis of cellular loci disrupted by papillomavirus 16 integration in cervical cancer: frequent viral integration in topologically destabilized and transcriptionally active chromosomal regions
Choo KB, et al.
Journal of Medical Virology, 49(1), 15-22 (1996)
Munjal M Acharya et al.
Cell transplantation, 23(10), 1255-1266 (2013-07-23)
Treatment of central nervous system (CNS) malignancies typically involves radiotherapy to forestall tumor growth and recurrence following surgical resection. Despite the many benefits of cranial radiotherapy, survivors often suffer from a wide range of debilitating and progressive cognitive deficits. Thus...
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