Showing 1-30 of 389 results for "M4403"
Zhicheng Shao et al.
Stem cells and development, 20(7), 1163-1170 (2010-11-23)
Destruction of the motor neurons will lead to loss of innervation of the somatic muscle, which has long been considered an illness with no remedy. The only possible treatment is to substitute the injured motor neurons by neurons differentiated from...
Christa van Kralingen et al.
PloS one, 8(12), e84269-e84269 (2013-12-25)
Astrocytes have critical roles in the human CNS in health and disease. They provide trophic support to neurons and are innate-immune cells with keys roles during states-of-inflammation. In addition, they have integral functions associated with maintaining the integrity of the...
Christina Chatzi et al.
PLoS biology, 9(4), e1000609-e1000609 (2011-05-03)
Although retinoic acid (RA) has been implicated as an extrinsic signal regulating forebrain neurogenesis, the processes regulated by RA signaling remain unclear. Here, analysis of retinaldehyde dehydrogenase mutant mouse embryos lacking RA synthesis demonstrates that RA generated by Raldh3 in...
Monica D Bjørge et al.
Cell reports, 13(12), 2671-2678 (2015-12-30)
Ogg1 and Mutyh DNA glycosylases cooperate to prevent mutations caused by 8-oxoG, a major premutagenic DNA lesion associated with cognitive decline. We have examined behavior and cognitive function in mice deficient of these glycosylases. Ogg1(-/-)Mutyh(-/-) mice were more active and...
Heng Zhao et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 26(9), 1114-1121 (2006-06-01)
Cerebral ischemic preconditioning protects against stroke, but is clinically feasible only when the occurrence of stroke is predictable. Reperfusion plays a critical role in cerebral injury after stroke; we tested the hypothesis that interrupting reperfusion lessens ischemic injury. We found...
Shanyan Chen et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 37(1), 188-200 (2015-12-19)
Matrix metalloproteinases (MMPs), particularly gelatinases (MMP-2/-9), are involved in neurovascular impairment after stroke. Detection of gelatinase activity in vivo can provide insight into blood-brain barrier disruption, hemorrhage, and nerve cell injury or death. We applied gelatinase-activatable cell-penetrating peptides (ACPP) with a...
Alan S Lewis et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(20), 7424-7440 (2011-05-20)
Output properties of neurons are greatly shaped by voltage-gated ion channels, whose biophysical properties and localization within axodendritic compartments serve to significantly transform the original input. The hyperpolarization-activated current, I(h), is mediated by hyperpolarization-activated cyclic nucleotide-gated (HCN) channels and plays...
Distinctive compartmental organization of human primary visual cortex.
Preuss, et al.
Proceedings of the National Academy of Sciences of the USA, 96, 11601-11606 (2019)
S Patodia et al.
Neuropathology and applied neurobiology, 47(1), 157-170 (2020-06-20)
Sudden unexpected death in epilepsy (SUDEP) likely arises as a result of autonomic dysfunction around the time of a seizure. In vivo MRI studies report volume reduction in the medulla and other brainstem autonomic regions. Our aim, in a pathology...
Virawudh Soontornniyomkij et al.
Age (Dordrecht, Netherlands), 34(2), 305-316 (2011-03-25)
Constitutive macroautophagy involved in the turnover of defective long-lived proteins and organelles is crucial for neuronal homeostasis. We hypothesized that macroautophagic dysregulation in selective brain regions was associated with memory impairment in aged mice. We used the single-trial object recognition...
Manli Zhong et al.
Frontiers in aging neuroscience, 13, 660249-660249 (2021-05-04)
Alzheimer's disease (AD) is a type of neurodegenerative disease that is associated with the accumulation of amyloid plaques. Increasing non-amyloidogenic processing and/or manipulating amyloid precursor protein signaling could reduce AD amyloid pathology and cognitive impairment. D-penicillamine (D-Pen) is a water-soluble...
M F Poitras et al.
Neuroscience, 148(1), 198-211 (2007-07-21)
Poly(ADP-ribose) polymerases (PARPs) are members of a family of enzymes that utilize nicotinamide adenine dinucleotide (NAD(+)) as substrate to form large ADP-ribose polymers (PAR) in the nucleus. PAR has a very short half-life due to its rapid degradation by poly(ADP-ribose)...
Anna B Toth et al.
Nature neuroscience, 16(10), 1417-1425 (2013-09-17)
Formation of appropriate synaptic connections is critical for proper functioning of the brain. After initial synaptic differentiation, active synapses are stabilized by neural activity-dependent signals to establish functional synaptic connections. However, the molecular mechanisms underlying activity-dependent synapse maturation remain to...
Grzegorz Wiera et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(5), 1240-1256 (2017-01-11)
Long-term potentiation (LTP) is widely perceived as a memory substrate and in the hippocampal CA3-CA1 pathway, distinct forms of LTP depend on NMDA receptors (nmdaLTP) or L-type voltage-gated calcium channels (vdccLTP). LTP is also known to be effectively regulated by...
Kun-Wei Wu et al.
Frontiers in cellular neuroscience, 11, 290-290 (2017-10-03)
Brain microvascular endothelial cells (BMEC) have been found to guide the migration, promote the survival and regulate the differentiation of neural cells. However, whether BMEC promote development and maturation of immature neurons is still unknown. Therefore, in this study, we...
Takeshi Yoshimatsu et al.
Development (Cambridge, England), 133(13), 2553-2563 (2006-05-27)
The transcription factor STAT3 promotes astrocytic differentiation of neural precursor cells (NPCs) during postnatal development of the mouse neocortex, but little has been known of the possible role of STAT3 in the embryonic neocortex. We now show that STAT3 is...
Peng-Peng Zhu et al.
Human molecular genetics, 15(8), 1343-1353 (2006-03-16)
The hereditary spastic paraplegias (HSPs) (SPG1-29) comprise a group of inherited neurological disorders characterized principally by spastic lower extremity weakness due to a length-dependent, retrograde axonopathy of corticospinal motor neurons. Mutations in the gene encoding the dynamin superfamily member atlastin-1...
Orr Hadass et al.
PloS one, 8(10), e76904-e76904 (2013-11-07)
Traumatic brain injury (TBI) is a leading cause of death and long-term disability. Following the initial insult, severe TBI progresses to a secondary injury phase associated with biochemical and cellular changes. The secondary injury is thought to be responsible for...
Giuseppe Biagini et al.
Journal of neuropathology and experimental neurology, 67(7), 687-701 (2008-07-04)
In limbic seizures, neuronal excitation is conveyed from the entorhinal cortex directly to CA1 and subicular regions. This phenomenon is associated with a reduced ability of CA3 to respond to entorhinal cortex inputs. Here, we describe a lesion that destroys...
Jacob Kjell et al.
Cell stem cell, 26(2), 277-293 (2020-02-08)
The mammalian brain contains few niches for neural stem cells (NSCs) capable of generating new neurons, whereas other regions are primarily gliogenic. Here we leverage the spatial separation of the sub-ependymal zone NSC niche and the olfactory bulb, the region...
Kohei Yamamizu et al.
Development (Cambridge, England), 141(22), 4254-4266 (2014-11-06)
Upon removal of culture conditions that maintain an undifferentiated state, mouse embryonic stem cells (ESCs) differentiate into various cell types. Differentiation can be facilitated by forced expression of certain transcription factors (TFs), each of which can generally specify a particular...
Ting Ting Lee et al.
Journal of neurovirology, 21(5), 535-543 (2015-06-04)
This investigation aimed to assess whether inhibition of cathecol-O-methyl transferase (COMT) by tolcapone could provide neuroprotection against HIV-associated neurodegenerative effects. This study was conducted based on a previous work, which showed that a single nucleotide polymorphism (SNP) at position 158...
Nathalie Pierrot et al.
Life science alliance, 2(2) (2019-03-22)
Mechanisms driving cognitive improvements following nuclear receptor activation are poorly understood. The peroxisome proliferator-activated nuclear receptor alpha (PPARα) forms heterodimers with the nuclear retinoid X receptor (RXR). We report that PPARα mediates the improvement of hippocampal synaptic plasticity upon RXR...
Yasushi Enokido et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 19(13), 1854-1856 (2005-09-15)
Cystathionine beta-synthase (CBS; EC is a key enzyme in the generation of cysteine from methionine. A deficiency of CBS leads to homocystinuria, an inherited human disease characterized by mental retardation, seizures, psychiatric disturbances, skeletal abnormalities, and vascular disorders; however...
A B Klein et al.
Neuroscience, 169(3), 1007-1016 (2010-06-26)
Changes in brain-derived neurotrophic factor (BDNF) expression have been implicated in the etiology of psychiatric disorders. To investigate pathological mechanisms elicited by perturbed BDNF signaling, we examined mutant mice with central depletion of BDNF (BDNF(2L/2LCk-cre)). A severe impairment specific for...
Iryna Leshchyns'ka et al.
Nature communications, 6, 8836-8836 (2015-11-28)
Alzheimer's disease (AD) is characterized by synapse loss due to mechanisms that remain poorly understood. We show that the neural cell adhesion molecule 2 (NCAM2) is enriched in synapses in the human hippocampus. This enrichment is abolished in the hippocampus...
Tanuja Chitnis et al.
The American journal of pathology, 170(5), 1695-1712 (2007-04-26)
Axonal damage secondary to inflammation is likely the substrate of chronic disability in multiple sclerosis and is found in the animal model of experimental autoimmune encephalomyelitis (EAE). Wld(s) mice have a triplication of the fusion gene Ube4b/Nmnat and a phenotype...
Increased hippocampal accumulation of autophagosomes predicts short-term recognition memory impairment in aged mice.
Soontornniyomkij V, et al.
Age (Dordrecht, Netherlands), 34(2), 305-316 (2012)

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