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Showing 1-16 of 16 results for "M7802" within Papers
Alexandra Fletcher-Jones et al.
eLife, 8 (2019-05-01)
Cannabinoid type one receptor (CB1R) is only stably surface expressed in axons, where it downregulates neurotransmitter release. How this tightly regulated axonal surface polarity is established and maintained is unclear. To address this question, we used time-resolved imaging to determine
Evaluation of the role of MAPK1 and CREB1 polymorphisms on treatment resistance, response and remission in mood disorder patients
Calati R, et al.
Progress in Neuro-Psychopharmacology & Biological Psychiatry, 44, 271-278 (2013)
Precise timing of ERK phosphorylation/dephosphorylation determines the outcome of trial repetition during long-term memory formation.
Kukushkin, et al.
Proceedings of the National Academy of Sciences of the USA, 119, e2210478119-e2210478119 (2023)
Giulio Innamorati et al.
Cell death & disease, 8(7), e2930-e2930 (2017-07-14)
Chorionic stem cells represent a promising opportunity for regenerative medicine. A deeper understanding of the stimuli that regulate their physiology, could lead to innovative clinical approaches. We revealed the presence of multiple sphingosine-1-phosphate (S1P) receptor isoforms in chorion-derived mesenchymal stem
Michael F Salvatore et al.
Journal of neurochemistry, 90(1), 245-254 (2004-06-17)
Glial cell line-derived neurotrophic factor (GDNF) improves motor dysfunction associated with aging in rats and non-human primates, in animal models of Parkinson's disease, and may improve motoric function in patients with advanced Parkinson's disease. These improvements are associated with increased
Franziska Altmüller et al.
PLoS genetics, 13(3), e1006684-e1006684 (2017-03-28)
Noonan syndrome (NS) is characterized by reduced growth, craniofacial abnormalities, congenital heart defects, and variable cognitive deficits. NS belongs to the RASopathies, genetic conditions linked to mutations in components and regulators of the Ras signaling pathway. Approximately 50% of NS
Douglas A Chapnick et al.
Molecular biology of the cell, 25(10), 1586-1593 (2014-03-14)
During wound healing and cancer metastasis, cells are frequently observed to migrate in collective groups. This mode of migration relies on the cooperative guidance of leader and follower cells throughout the collective group. The upstream determinants and molecular mechanisms behind
Renato G S Chirivi et al.
Journal of neurochemistry, 101(3), 829-840 (2007-02-03)
The neuronal protein tyrosine phosphatases encoded by mouse gene Ptprr (PTPBR7, PTP-SL, PTPPBSgamma-42 and PTPPBSgamma-37) have been implicated in mitogen-activated protein (MAP) kinase deactivation on the basis of transfection experiments. To determine their physiological role in vivo, we generated mice
Dual regulation of miRNA biogenesis generates target specificity in neurotrophin-induced protein synthesis
Huang YWA, et al.
Cell, 148(5), 933-946 (2012)
A leak pathway for luminal protons in endosomes drives oncogenic signalling in glioblastoma
Kondapalli KC, et al.
Nature Communications, 6(5), 6289-6289 (2015)
Transcriptional consequences of 16p11. 2 deletion and duplication in mouse cortex and multiplex autism families
Blumenthal I, et al.
American Journal of Human Genetics, 94(6), 870-883 (2014)
Roser Buscà et al.
BMC evolutionary biology, 15, 179-179 (2015-09-04)
The Ras/Raf/MEK/ERK signaling pathway is involved in essential cell processes and it is abnormally activated in ~30 % of cancers and cognitive disorders. Two ERK isoforms have been described, ERK1 and ERK2; ERK2 being regarded by many as essential due
Frances Evans et al.
BioMed research international, 2021, 2641068-2641068 (2021-11-02)
Gramicidin is a thoroughly studied cation ionophore widely used to experimentally manipulate the plasma membrane potential (PMP). In addition, it has been established that the drug, due to its hydrophobic nature, is capable of affecting the organization of membrane lipids.
Leader cell positioning drives wound-directed collective migration in TGFbeta-stimulated epithelial sheets
Chapnick DA and Liu X
Molecular Biology of the Cell, 25(10), 1586-1593 (2014)
Jie Liu et al.
Molecular medicine reports, 24(3) (2021-07-20)
Previous studies have identified microRNA (miRNA/miR)‑3613‑3p as a heat stress (HS)‑related miRNA in endothelial cells that can lead to apoptosis. However, the mechanism underlying the miR‑3613‑3p‑mediated apoptosis of HS‑exposed endothelial cells remains unclear. In the present study, western blot analysis
Luis Solabre Valois et al.
IBRO neuroscience reports, 10, 196-207 (2021-05-28)
Botulinum neurotoxins (BoNTs) are extremely potent naturally occurring poisons that act by silencing neurotransmission. Intriguingly, in addition to preventing presynaptic vesicle fusion, BoNT serotype A (BoNT/A) can also promote axonal regeneration in preclinical models. Here we report that the non-toxic
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