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Showing 1-25 of 25 results for "M7898" within Papers
Yan Lu et al.
Neural regeneration research, 17(4), 911-919 (2021-09-03)
Peripheral nerve injury repair requires a certain degree of cooperation between axon regeneration and Wallerian degeneration. Therefore, investigating how axon regeneration and degeneration work together to repair peripheral nerve injury may uncover the molecular mechanisms and signal cascades underlying peripheral
Yunsong Zhang et al.
Journal of molecular neuroscience : MN, 72(6), 1402-1412 (2022-05-17)
Cellular metabolism is essentially linked to tissue remodeling and organ regeneration. MOGS, a gene that encodes cellular metabolism-related protein mannosyl-oligosaccharide glucosidase, was found to be upregulated in nerve segments after peripheral nerve injury. Bioinformatic analyses identified upstream regulators of MOGS
Yanni Ge et al.
Molecular therapy. Nucleic acids, 26, 1201-1214 (2021-12-03)
DNA methylation is considered to play an important role in the development of diabetic retinopathy. Here, our goal was to investigate the precise role of methyl-CpG binding domain protein 2 (Mbd2) in the apoptosis of retinal ganglion cells (RGCs) in
Dongren Yang et al.
The Journal of cell biology, 168(4), 655-666 (2005-02-09)
Schwann cells form basal laminae (BLs) containing laminin-2 (Ln-2; heterotrimer alpha2beta1gamma1) and Ln-8 (alpha4beta1gamma1). Loss of Ln-2 in humans and mice carrying alpha2-chain mutations prevents developing Schwann cells from fully defasciculating axons, resulting in partial amyelination. The principal pathogenic mechanism
Yinying Shen et al.
Frontiers in cellular neuroscience, 15, 743532-743532 (2021-11-02)
CD146 is cell adhesion molecule and is implicated in a variety of physiological and pathological processes. However, the involvement of CD146 in peripheral nerve regeneration has not been studied yet. Here, we examine the spatial and temporal expression pattern of
Qian-Qian Cao et al.
Neural regeneration research, 16(11), 2316-2323 (2021-04-06)
Although the transcriptional alterations inside the facial nucleus after facial nerve injury have been well studied, the gene expression changes in the facial nerve trunk after injury are still unknown. In this study, we established an adult rat model of
Chu Chen et al.
Experimental and therapeutic medicine, 17(5), 4116-4122 (2019-04-17)
MicroRNAs (miRNAs) are non-coding RNAs that regulate various tissues and organs, including the nervous system. Peripheral nerve injury is a common pathology of the nervous system and leads to differential expressions of a variety of miRNAs. Previously, a group of
Sailing Chen et al.
Journal of neurochemistry, 166(4), 678-691 (2023-07-13)
Peripheral nerves have limited regeneration ability following nerve injury. Applying growth factors with neurotrophic roles is beneficial for accelerating peripheral nerve regeneration. Here we show that after rat sciatic nerve injury, growth factor amphiregulin (AREG) is upregulated in Schwann cells
Glial-mediated neuroprotection: Evidence for the protective role of the NO-cGMP pathway via neuron-glial communication in the peripheral nervous system.
Thippeswamy T, et al.
Glia, 49(2), 197-210 (2005)
Rapidly purified ganglion cells from neonatal mouse retinas allow studies of mitochondrial morphology and autophagy.
Zaninello M and Scorrano L
Pharmacological Research, 138, 16-24 (2018)
Wendy A Neveu et al.
American journal of physiology. Cell physiology, 309(9), C616-C626 (2015-09-04)
Idiopathic pulmonary fibrosis is a progressive lung disease that increases in incidence with age. We identified a profibrotic lung phenotype in aging mice characterized by an increase in the number of fibroblasts lacking the expression of thymocyte differentiation antigen 1
Jiang-Bo Wang et al.
Cell & bioscience, 10, 98-98 (2020-08-28)
Schwann cells (SCs) play a crucial role in Wallerian degeneration after peripheral nerve injury. The expression of genes in SCs undergo a series of changes, which greatly affect the proliferation and apoptosis of SCs as well as the fate of
Dandan Gu et al.
Molecular medicine reports, 16(6), 7993-8002 (2017-10-07)
Specification of distinct cell types from Müller glial cells is key to the potential application of endogenous repair in retinal regeneration. Sonic hedgehog (SHH) has been established as a potent mitogen for rat Müller glial cells, which also induces Müller
Manuela Schmidt et al.
The Journal of investigative dermatology, 135(7), 1893-1902 (2015-03-05)
Fibroblasts provide matrix and regulatory mediators to the microenvironment and thereby contribute to maintenance of tissue homeostasis, wound healing, and tumor progression. In the present study, we addressed the functional relevance of Thy-1 for fibroblast functions in vitro and in
Yuqing Feng et al.
Molecular medicine (Cambridge, Mass.), 29(1), 9-9 (2023-01-19)
Retinal ganglion cells (RGCs) apoptosis is a vital manifestation of retinal ischemia/reperfusion (I/R) injury, yet the underlying mechanisms are not well understood. The contribution of long noncoding RNAs (lncRNAs) to this cellular process is currently being explored. Based on a
Min Cai et al.
Neural regeneration research, 17(4), 845-853 (2021-09-03)
Wallerian degeneration is a complex biological process that occurs after nerve injury, and involves nerve degeneration and regeneration. Schwann cells play a crucial role in the cellular and molecular events of Wallerian degeneration of the peripheral nervous system. However, Wallerian
Directed transdifferentiation of Muller glial cells to photoreceptors using the sonic hedgehog signaling pathway agonist purmorphamine.
Gu D, et al.
Molecular Medicine Reports, 16(6), 7993-8002 (2017)
Qianqian Chen et al.
Cell death & disease, 12(5), 417-417 (2021-04-24)
Leukemia inhibitory factor (LIF) is a pleiotropic cytokine that stimulates neuronal development and survival. Our previous study has demonstrated that LIF mRNA is dysregulated in the peripheral nerve segments after nerve injury. Here, we show that LIF protein is abundantly
Zhenghui Cheng et al.
BMC molecular and cell biology, 22(1), 21-21 (2021-04-09)
Schwann cells (SCs) play a crucial role in the repair of peripheral nerves. This is due to their ability to proliferate, migrate, and provide trophic support to axon regrowth. During peripheral nerve injury, SCs de-differentiate and reprogram to gain the
Tuchen Guan et al.
Journal of neurochemistry, 165(6), 842-859 (2023-03-28)
Schwann cells play an essential role in peripheral nerve regeneration by generating a favorable microenvironment. Gastric inhibitory peptide/gastric inhibitory peptide receptor (GIP/GIPR) axis deficiency leads to failure of sciatic nerve repair. However, the underlying mechanism remains elusive. In this study
Jinghui Xu et al.
Molecular medicine (Cambridge, Mass.), 29(1), 79-79 (2023-06-27)
Myelin sheath is a crucial accessory to the functional nerve-fiber unit, its disruption or loss can lead to axonal degeneration and subsequent neurodegenerative diseases (NDs). Notwithstanding of substantial progress in possible molecular mechanisms underlying myelination, there is no therapeutics that
Qian-Qian Chen et al.
Neural regeneration research, 18(7), 1584-1590 (2022-12-27)
Neurotrophic factors, particularly nerve growth factor, enhance neuronal regeneration. However, the in vivo applications of nerve growth factor are largely limited by its intrinsic disadvantages, such as its short biological half-life, its contribution to pain response, and its inability to
Yanni Ge et al.
Molecular therapy. Nucleic acids, 19, 1250-1265 (2020-02-23)
Recent studies reported that DNA methylation was involved in retinal cell death. Methyl-CpG binding domain protein 2 (Mbd2) is one of the DNA methylation readers. Its role and mechanism of regulation remain unclear. The ischemia/reperfusion (I/R) model in mice primary culture
Wen-Feng Su et al.
Glia, 67(1), 78-90 (2018-10-12)
Of the seven P2X receptor subtypes, P2X4 receptor (P2X4R) is widely distributed in the central nervous system, including in neurons, astrocytes, and microglia. Accumulating evidence supports roles for P2X4R in the central nervous system, including regulating cell excitability, synaptic transmission
Yannick Poitelon et al.
Methods in molecular biology (Clifton, N.J.), 1739, 233-253 (2018-03-17)
In the peripheral nervous system, axons dictate the differentiation state of Schwann cells. Most of this axonal influence on Schwann cells is due to juxtacrine interactions between axonal transmembrane molecules (e.g., the neuregulin growth factor) and receptors on the Schwann
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