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Venkaiah Betapudi et al.
Journal of molecular biology, 407(5), 673-686 (2011-02-15)
Myosin II motor proteins play important roles in cell migration. Although myosin II filament assembly plays a key role in the stabilization of focal contacts at the leading edge of migrating cells, the mechanisms and signaling pathways regulating the localized...
Kenneth Wee et al.
Journal of cell science, 133(13) (2020-05-30)
Cell extrusion is a morphogenetic process that is implicated in epithelial homeostasis and elicited by stimuli ranging from apoptosis to oncogenic transformation. To explore whether the morphogenetic transcription factor Snail (SNAI1) induces extrusion, we inducibly expressed a stabilized Snail6SA transgene...
Alexis J Haas et al.
Cell reports, 32(3), 107924-107924 (2020-07-23)
Tight-junction-regulated actomyosin activity determines epithelial and endothelial tension on adherens junctions and drives morphogenetic processes; however, whether or not tight junctions themselves are under tensile stress is not clear. Here, we use a tension sensor based on ZO-1, a scaffolding...
Natsuko Izumi et al.
Cancer science, 103(1), 50-57 (2011-09-29)
Heat shock protein 90 (Hsp90), a conserved molecular chaperone for a specific set of proteins critical for signal transduction including several oncogenic proteins, has been recognized as a promising target for anticancer therapy. Hsp90 inhibition also sensitizes cancer cells to...
Epithelial relaxation mediated by the myosin phosphatase regulator Mypt1 is required for brain ventricle lumen expansion and hindbrain morphogenesis
Gutzman JH and Sive H
Development, 137(5), 795-804 (2010)
Nisha Bte Mohd Rafiq et al.
Nature materials, 18(6), 638-649 (2019-05-23)
The interrelationship between microtubules and the actin cytoskeleton in mechanoregulation of integrin-mediated adhesions is poorly understood. Here, we show that the effects of microtubules on two major types of cell-matrix adhesion, focal adhesions and podosomes, are mediated by KANK family...
Masaki Tsuchiya et al.
Nature communications, 9(1), 2049-2049 (2018-05-26)
Myotube formation by fusion of myoblasts and subsequent elongation of the syncytia is essential for skeletal muscle formation. However, molecules that regulate myotube formation remain elusive. Here we identify PIEZO1, a mechanosensitive Ca2+ channel, as a key regulator of myotube...
Hitomi Nakashima et al.
Biophysics and physicobiology, 12, 21-29 (2015-01-01)
Cell-crawling migration plays an essential role in complex biological phenomena. It is now generally believed that many processes essential to such migration are regulated by microtubules in many cells, including fibroblasts and neurons. However, keratocytes treated with nocodazole, which is...
Wenhong Li et al.
Journal of cell science, 134(8) (2021-03-17)
The mechanisms underlying the cellular response to extracellular matrices (ECMs) that consist of multiple adhesive ligands are still poorly understood. Here, we address this topic by monitoring specific cellular responses to two different extracellular adhesion molecules - the main integrin...
Armen Petrosyan et al.
The Journal of biological chemistry, 290(10), 6256-6269 (2015-01-22)
Core 2 N-acetylglucosaminyltransferase 2/M (C2GnT-M) synthesizes all three β6GlcNAc branch structures found in secreted mucins. Loss of C2GnT-M leads to development of colitis and colon cancer. Recently we have shown that C2GnT-M targets the Golgi at the Giantin site and...
Mabel Lum et al.
Pathogens and disease, 72(3), 174-187 (2014-07-06)
A key feature of Shigella pathogenesis is the ability to spread from cell-to-cell post-invasion. This is dependent on the bacteria's ability to initiate de novo F-actin tail polymerisation, followed by protrusion formation, uptake of bacteria-containing protrusion and finally, lysis of...
Eric M Balzer et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 26(10), 4045-4056 (2012-06-19)
Cell migration on planar surfaces is driven by cycles of actin protrusion, integrin-mediated adhesion, and myosin-mediated contraction; however, this mechanism may not accurately describe movement in 3-dimensional (3D) space. By subjecting cells to restrictive 3D environments, we demonstrate that physical...
Yosuke Funato et al.
Developmental cell, 55(4), 387-397 (2020-09-13)
Extracellular pH is usually maintained around 7.4 in multicellular organisms, and cells are optimized to proliferate under this condition. Here, we find cells can adapt to a more acidic pH of 6.5 and become addicted to this acidic microenvironment by...
Chad D Williamson et al.
Molecular biology of the cell, 30(12), 1477-1489 (2019-04-11)
Macropinocytosis is an actin-driven form of clathrin-independent endocytosis that generates an enlarged structure, the macropinosome. Although many studies focus on signaling molecules and phosphoinositides involved in initiating macropinocytosis, the commitment to forming a macropinosome and the handling of that membrane...
Yuan-Chen Chang et al.
Molecular biology of the cell, 19(5), 2147-2153 (2008-02-22)
The RhoA GTPase plays a vital role in assembly of contractile actin-myosin filaments (stress fibers) and of associated focal adhesion complexes of adherent monolayer cells in culture. GEF-H1 is a microtubule-associated guanine nucleotide exchange factor that activates RhoA upon release...
Hans M Wyss et al.
American journal of physiology. Cell physiology, 300(3), C397-C405 (2010-12-03)
The mechanical properties of tissues and cells including renal glomeruli are important determinants of their differentiated state, function, and responses to injury but are not well characterized or understood. Understanding glomerular mechanics is important for understanding renal diseases attributable to...
Nayana Tusamda Wakhloo et al.
Biomaterials, 234, 119746-119746 (2020-01-17)
Cell deformation occurs in many critical biological processes, including cell extravasation during immune response and cancer metastasis. These cells deform the nucleus, their largest and stiffest organelle, while passing through narrow constrictions in vivo and the underlying mechanisms still remain...
Wolfgang H Ziegler et al.
International journal of molecular sciences, 21(14) (2020-07-24)
Mutations of the Pkhd1 gene cause autosomal recessive polycystic kidney disease (ARPKD). Pkhd1 encodes fibrocystin/polyductin (FPC), a ciliary type I membrane protein of largely unknown function, suggested to affect adhesion signaling of cells. Contributions of epithelial cell adhesion and contractility...
Shumin Xia et al.
ACS biomaterials science & engineering, 5(8), 3828-3842 (2019-08-12)
The mechanical microenvironment serves as an important factor influencing stem cell differentiation. Mechanobiological responses depend strongly on actomyosin contractility and integrin-based cell-extracellular matrix (ECM) interactions mediated by adhesive structures such as focal adhesions (FAs). While the roles of FAs in...
Jordan R Beach et al.
Nature cell biology, 19(2), 85-93 (2017-01-24)
The cellular mechanisms governing non-muscle myosin II (NM2) filament assembly are largely unknown. Using EGFP-NM2A knock-in fibroblasts and multiple super-resolution imaging modalities, we characterized and quantified the sequential amplification of NM2 filaments within lamellae, wherein filaments emanating from single nucleation...
Joe Swift et al.
Science (New York, N.Y.), 341(6149), 1240104-1240104 (2013-08-31)
Tissues can be soft like fat, which bears little stress, or stiff like bone, which sustains high stress, but whether there is a systematic relationship between tissue mechanics and differentiation is unknown. Here, proteomics analyses revealed that levels of the...
Thomas Daubon et al.
Journal of cell science, 129(13), 2586-2598 (2016-05-28)
Podosomes are dynamic cell-matrix contact structures that combine several key abilities, including adhesion, matrix degradation and mechanosensing. These actin-based cytoskeletal structures have been mostly studied in monocytic cells, but much less is known about those formed in other lineages. In...
Adhesion-dependent and contractile ring-independent equatorial furrowing during cytokinesis in mammalian cells
Kanada M, et al.
Molecular Biology of the Cell, 16(8), 3865-3872 (2005)
Nehal Dwivedi et al.
Biochemical and biophysical research communications, 543, 38-44 (2021-01-29)
Survival and maintenance of normal physiological functions depends on continuous interaction of cells with its microenvironment. Cells sense the mechanical properties of underlying substrate by applying force and modulate their behaviour in response to the resistance offered by the substrate....
Claudia Schäfer et al.
Cell adhesion & migration, 4(2), 215-225 (2010-02-25)
Migration of cells is one of the most essential prerequisites to form higher organisms and depends on a strongly coordinated sequence of processes. Early migratory events include substrate sensing, adhesion formation, actin bundle assembly and force generation. While substrate sensing...
Jordan R Beach et al.
BMC cell biology, 12, 52-52 (2011-12-06)
Phosphorylation of non-muscle myosin II regulatory light chain (RLC) at Thr18/Ser19 is well established as a key regulatory event that controls myosin II assembly and activation, both in vitro and in living cells. RLC can also be phosphorylated at Ser1/Ser2/Thr9...
Luca Musante et al.
Scientific reports, 10(1), 3701-3701 (2020-03-01)
Urinary extracellular vesicles (uEVs) provide bio-markers for kidney and urogenital diseases. Centrifugation is the most common method used to enrich uEVs. However, a majority of studies to date have focused on the ultracentrifugation pellet, potentially losing a novel source of...
Ying-Yi Lu et al.
Advances in wound care, 9(9), 491-501 (2020-09-18)
Objective: Keloid is an abnormal scar that often develops in high-tension skin. It is caused by excessive fibroblast proliferation and collagen deposition. Nonmuscle myosin IIA (NM-IIA) is an important motor protein that regulates the mechanical transduction of cells. However, the...
Chika Okimura et al.
Scientific reports, 8(1), 10615-10615 (2018-07-19)
Crawling migration plays an essential role in a variety of biological phenomena, including development, wound healing, and immune system function. Keratocytes are wound-healing cells in fish skin. Expansion of the leading edge of keratocytes and retraction of the rear are...
Masamitsu Kanada et al.
Molecular biology of the cell, 16(8), 3865-3872 (2005-06-10)
Myosin II-dependent contraction of the contractile ring drives equatorial furrowing during cytokinesis in animal cells. Nonetheless, myosin II-null cells of the cellular slime mold Dictyostelium divide efficiently when adhering to substrates by making use of polar traction forces. Here, we...
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