Showing 1-30 of 3944 results for "M8266"
Ikue Nagakura et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(31), 10256-10263 (2014-08-01)
Accumulating evidence points to a role for Janus kinase/signal transducers and activators of transcription (STAT) immune signaling in neuronal function; however, its role in experience-dependent plasticity is unknown. Here we show that one of its components, STAT1, negatively regulates the...
Michael S Hildebrand et al.
Scientific reports, 5, 17816-17816 (2015-12-10)
Febrile seizures (FS) are the most common seizure syndrome and are potentially a prelude to more severe epilepsy. Although zinc (Zn(2+)) metabolism has previously been implicated in FS, whether or not variation in proteins essential for Zn(2+) homeostasis contributes to...
Dhilushi D Wijayakumara et al.
The Journal of pharmacology and experimental therapeutics, 354(3), 417-425 (2015-07-15)
Given the prime importance of UDP-glucuronosyltransferase (UGT) 2B15 and UGT2B17 in inactivating testosterone and dihydrotestosterone, control of their expression and activity in the prostate is essential for androgen signaling homeostasis in this organ. Although several studies provide evidence of transcriptional...
Deepshikha Verma et al.
PloS one, 10(7), e0133186-e0133186 (2015-07-16)
The study of genomic variability within various pathogenic and non-pathogenic strains of mycobacteria provides insight into their evolution and pathogenesis. The mycobacterial genome encodes seven cutinase-like proteins and each one of these exhibit distinct characteristics. We describe the presence of...
Giselli Scaini et al.
Neurochemical research, 40(5), 885-893 (2015-02-15)
Maple syrup urine disease (MSUD) is caused by an inborn error in metabolism resulting from a deficiency in the branched-chain α-keto acid dehydrogenase complex activity. This blockage leads to accumulation of the branched-chain amino acids (BCAA) leucine, isoleucine and valine...
J Velíšková et al.
Journal of neuroendocrinology, 27(12), 911-920 (2015-11-07)
Neuropeptide Y (NPY) is an endogenous modulator of neuronal activity affecting both GABAergic and glutamatergic transmission. Previously, we found that oestradiol modifies the number of NPY immunoreactive neurones in the hippocampal dentate gyrus. In the present study, we investigated which...
Sureewan Bumrungthai et al.
PloS one, 10(5), e0127109-e0127109 (2015-05-27)
MicroRNA-21 (miR-21) is recognized as an oncomir and shows up-regulation in many types of human malignancy. The aim of this study was to investigate the association of miR-21 expression associated with HPV infection in normal and abnormal cervical tissues. Cervical...
Min Li et al.
Nature communications, 6, 6720-6720 (2015-04-09)
DNA topoisomerase I (TOP1) has an important role in maintaining DNA topology by relaxing supercoiled DNA. Here we show that the K391 and K436 residues of TOP1 are SUMOylated by the PIAS1-SRSF1 E3 ligase complex in the chromatin fraction containing...
Shodai Kawano et al.
Journal of biochemistry, 158(5), 413-423 (2015-05-17)
Transcriptional co-activator with PSD-95/Dlg-A/ZO-1 (PDZ)-binding motif (TAZ) regulates in cell proliferation and differentiation. In mesenchymal stem cells it promotes osteogenesis and myogenesis, and suppresses adipogenesis. TAZ activators are expected to prevent osteoporosis, obesity and muscle atrophy. TAZ activation induces epithelial-mesenchymal...
Shinji Sakuma et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 92, 56-64 (2015-02-28)
We evaluated cross-reactivity of immunoglobulin A (IgA) secreted on the nasal mucosa in mice that were nasally inoculated 4 times with a mixture of inactivated H1N1 influenza A viruses and poly(N-vinylacetamide-co-acrylic acid) (PNVA-co-AA) bearing d-octaarginine at 7-day intervals. Three viral...
María C Ovejero-Benito et al.
Cell cycle (Georgetown, Tex.), 14(14), 2311-2322 (2015-05-07)
Nuclear DNA duplication in the absence of cell division (i.e. endoreplication) leads to somatic polyploidy in eukaryotic cells. In contrast to some invertebrate neurons, whose nuclei may contain up to 200,000-fold the normal haploid DNA amount (C), polyploid neurons in...
Charlene L McCord et al.
Molecular phylogenetics and evolution, 94(Pt A), 397-409 (2015-09-27)
The triggerfishes (family Balistidae) and filefishes (family Monacanthidae) comprise a charismatic superfamily (Balistoidea) within the diverse order Tetraodontiformes. This group of largely marine fishes occupies an impressive ecological range across the world's oceans, and is well known for its locomotor...
Shaik Mohammad Naushad et al.
Molecular and cellular biochemistry, 392(1-2), 273-280 (2014-03-29)
Obesity, genetic polymorphisms of xenobiotic metabolic pathway, hypermethylation of tumor suppressor genes, and hypomethylation of proapoptotic genes are known to be independent risk factors for breast cancer. The objective of this study is to evaluate the combined effect of these...
Joanna K Hubbard et al.
Ecology and evolution, 5(16), 3436-3449 (2015-09-19)
Phenotypic differences among individuals are often linked to differential survival and mating success. Quantifying the relative influence of genetic and environmental variation on phenotype allows evolutionary biologists to make predictions about the potential for a given trait to respond to...
Elizabeth A Wellberg et al.
Breast cancer research : BCR, 16(6), 481-481 (2014-12-05)
Spot14 (S14), encoded by the THRSP gene, regulates de novo fatty acid synthesis in the liver, adipose, and lactating mammary gland. We recently showed that S14 stimulated fatty acid synthase (FASN) activity in vitro, and increased the synthesis of fatty...
Myong-Ho Jeong et al.
Nature communications, 5, 5455-5455 (2014-11-20)
Canonical Wnt signalling regulates expansion of neural progenitors and functions as a dorsalizing signal in the developing forebrain. In contrast, the multifunctional co-receptor Cdo promotes neuronal differentiation and is important for the function of the ventralizing signal, Shh. Here we...
Jia-Yan Yao et al.
World journal of gastroenterology, 21(14), 4232-4239 (2015-04-22)
To investigate the relationship between interleukin-21 (IL21) gene polymorphisms and chronic hepatitis B virus (HBV) infection in a Chinese population. In this case-control study, 366 Chinese HBV-infected patients were recruited and divided into hepatocellular carcinoma (HCC; n = 94) and...
Marissa Suchyta et al.
Genes, 6(2), 252-266 (2015-05-20)
The initiation of DNA replication is tightly regulated in order to ensure that the genome duplicates only once per cell cycle. In vertebrate cells, the unstable regulatory protein Geminin prevents a second round of DNA replication by inhibiting the essential...
Amber Hanif Palla et al.
Journal of ethnopharmacology, 160, 61-68 (2014-11-30)
Linum usitatissimum, commonly known as Flaxseed has traditionally been used for the management of diarrhea and gastrointestinal infections. This study was planned to assess pharmacological basis for the medicinal use of Flaxseed in infectious and non-infectious diarrhea. The crude aqueous-methanolic...
Benjamin P Beaton et al.
Xenotransplantation, 22(5), 379-390 (2015-09-19)
Recent advancements in gene editing techniques have increased in number and utility. These techniques are an attractive alternative to conventional gene targeting methods via homologous recombination due to the ease of use and the high efficiency of gene editing. We...
Ledys S Copete et al.
BMC biotechnology, 15, 74-74 (2015-08-14)
Fungal laccases are multicopper oxidases (MCOs) with high biotechnological potential due to their capability to oxidize a wide range of aromatic contaminants using oxygen from the air. Albeit the numerous laccase-like genes described in ascomycete fungi, ascomycete laccases have been...
Bianca Dauber et al.
Journal of virology, 88(17), 9624-9632 (2014-06-13)
We recently demonstrated that the virion host shutoff (vhs) protein, an mRNA-specific endonuclease, is required for efficient herpes simplex virus 1 (HSV-1) replication and translation of viral true-late mRNAs, but not other viral and cellular mRNAs, in many cell types...
Frank Yang et al.
Biomedical engineering online, 14, 109-109 (2015-11-28)
Microelectrode array (MEA) devices are frequently used in neural circuit studies, especially in retinal prosthesis. For a high throughput stimulation and recording paradigm, it is desirable to obtain the responses of multiple surface RGCs initiated from the electrical signals delivered...
Carla B Mellough et al.
Stem cells (Dayton, Ohio), 33(8), 2416-2430 (2015-04-02)
We and others have previously demonstrated that retinal cells can be derived from human embryonic stem cells (hESCs) and induced pluripotent stem cells under defined culture conditions. While both cell types can give rise to retinal derivatives in the absence...
Sascha Rother et al.
PloS one, 10(8), e0135682-e0135682 (2015-08-27)
Studying genetic diversity of immunologically relevant molecules can improve our knowledge on their functional spectrum in normal immune responses and may also uncover a possible role of different variants in diseases. We characterized the c.503T>C polymorphism in the human KLRB1...
Anna Fiust et al.
Journal of applied genetics, 56(3), 299-309 (2015-02-27)
The tolerance of spring barley (Hordeum vulgare L.) cultivars to spring drought is an important agronomic trait affecting crop yield and quality in Poland. Therefore, breeders require new molecular markers to select plants with lower spring drought susceptibility. With the...
Tuyen Thi Ngoc Tran et al.
Bioorganic & medicinal chemistry, 22(18), 5110-5116 (2014-02-18)
Natural products represent compound classes with high chemical and structural diversity and various biological activities. Libraries based on natural products are valuable starting point in the search for novel biologically active substances. Here we report on the identification of the...
Harindranath Kadavath et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(24), 7501-7506 (2015-06-03)
The structure, dynamic behavior, and spatial organization of microtubules are regulated by microtubule-associated proteins. An important microtubule-associated protein is the protein Tau, because its microtubule interaction is impaired in the course of Alzheimer's disease and several other neurodegenerative diseases. Here...
Takayuki Sekimoto et al.
Molecular and cellular biology, 35(4), 699-715 (2014-12-10)
DNA rereplication is a major form of aberrant replication that causes genomic instabilities, such as gene amplification. However, little is known about which DNA polymerases are involved in the process. Here, we report that low-fidelity Y-family polymerases (Y-Pols), Pol η...
Baoting Dou et al.
The Analyst, 140(17), 5981-5986 (2015-07-17)
By coupling target DNA-induced reconfiguration of the dsDNA probes with enzyme-assisted target recycling amplification, we describe the development of a signal-on electrochemical sensing approach for sensitive detection of hereditary tyrosinemia type I gene. The dsDNA probes are self-assembled on the...

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